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P86243

- TOMT_PANTR

UniProt

P86243 - TOMT_PANTR

Protein

Transmembrane O-methyltransferase

Gene

LRTOMT

Organism
Pan troglodytes (Chimpanzee)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (05 May 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei137 – 1371S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei145 – 1451S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei163 – 1631S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei193 – 1931S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation

    GO - Molecular functioni

    1. catechol O-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. catecholamine metabolic process Source: UniProtKB-KW
    2. neurotransmitter catabolic process Source: UniProtKB-KW
    3. sensory perception of sound Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Catecholamine metabolism, Hearing, Neurotransmitter degradation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane O-methyltransferaseBy similarity (EC:2.1.1.6)
    Alternative name(s):
    Catechol O-methyltransferase 2By similarity
    Protein LRTOMT21 Publication
    Gene namesi
    Name:LRTOMT1 Publication
    Synonyms:COMT2By similarity, TOMTBy similarity
    OrganismiPan troglodytes (Chimpanzee)
    Taxonomic identifieri9598 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaePan
    ProteomesiUP000002277: Unplaced

    Subcellular locationi

    Isoform 1 : Membrane Sequence Analysis; Single-pass membrane protein Sequence Analysis
    Isoform 2 : Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291Transmembrane O-methyltransferasePRO_0000372487Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP86243.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni139 – 1402S-adenosyl-L-methionine bindingPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025782. Catechol_O-MeTrfase.
    IPR002935. O-MeTrfase_3.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR10509. PTHR10509. 1 hit.
    PfamiPF01596. Methyltransf_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51682. SAM_OMT_I. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: P86243-1) [UniParc]FASTAAdd to Basket

    Also known as: D'1 Publication

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGTPWRKRKG IAGPGLPHLS CALVLQPRAQ VGTMSPAIAL AFLPLVVTLL    50
    VRYRHYFRLL VRTVLLRSLR DCLSGLRIEE RAFSYVLTHA LPGDPGHILT 100
    TLDHWSSCCE YLSHMGPVKG QILMRLVEEK APACVLELGT YCGYSTLLIA 150
    RALPPGGRLL TVERDPRTAA VAEKLIRLAG FDEHMVELIV GSSEDVIPCL 200
    RTQYQLSRAD LVLLAHRPRC YLRDLQLLEA HALLPAGATV LADHVLFPGA 250
    PRFLQYAKSC GRYRCRLHHT GLPDFPAIKD GIAQLTYAGP G 291
    Length:291
    Mass (Da):32,124
    Last modified:May 5, 2009 - v1
    Checksum:i171964FA01FA2E67
    GO
    Isoform 21 Publication (identifier: P86243-2) [UniParc]FASTAAdd to Basket

    Also known as: E'1 Publication

    The sequence of this isoform differs from the canonical sequence as follows:
         28-67: Missing.

    Show »
    Length:251
    Mass (Da):27,517
    Checksum:i27F8B5080EE5E7D7
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei28 – 6740Missing in isoform 2. 1 PublicationVSP_037158Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU627074 mRNA. No translation available.
    EU627075 mRNA. No translation available.
    RefSeqiNP_001186282.1. NM_001199353.1. [P86243-1]
    NP_001269004.1. NM_001282075.1. [P86243-2]
    UniGeneiPtr.6307.

    Genome annotation databases

    GeneIDi748243.
    KEGGiptr:748243.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU627074 mRNA. No translation available.
    EU627075 mRNA. No translation available.
    RefSeqi NP_001186282.1. NM_001199353.1. [P86243-1 ]
    NP_001269004.1. NM_001282075.1. [P86243-2 ]
    UniGenei Ptr.6307.

    3D structure databases

    ProteinModelPortali P86243.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 748243.
    KEGGi ptr:748243.

    Organism-specific databases

    CTDi 220074.

    Miscellaneous databases

    NextBioi 20914977.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025782. Catechol_O-MeTrfase.
    IPR002935. O-MeTrfase_3.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR10509. PTHR10509. 1 hit.
    Pfami PF01596. Methyltransf_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51682. SAM_OMT_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain1 Publication.

    Entry informationi

    Entry nameiTOMT_PANTR
    AccessioniPrimary (citable) accession number: P86243
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In primates, this protein is produced by a bicistronic gene which also produces the LRRC51 protein from an overlapping reading frame. In rodents, these proteins are produced by 2 separate adjacent genes which together are orthologous to the single primate gene.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3