P86231 (ODO1_MESAU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-oxoglutarate dehydrogenase, mitochondrial
EC=1.2.4.2

Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name=OGDC-E1
Alpha-ketoglutarate dehydrogenase

Gene names

Name:

OGDH

Organism

Mesocricetus auratus (Golden hamster)

Taxonomic identifier

10036 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Mesocricetus

Protein attributes

Sequence length	180 AA.
Sequence status	Fragments.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. UniProtKB Q02218
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. UniProtKB Q02218
Cofactor	Thiamine pyrophosphate By similarity. UniProtKB Q02218
Enzyme regulation	Catabolite repressed By similarity. UniProtKB Q02218
Subcellular location	Mitochondrion matrix By similarity UniProtKB Q02218.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Mitochondrion
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Cellular_component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: EC thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›180	›180	2-oxoglutarate dehydrogenase, mitochondrial		PRO_0000394738
Experimental info
	Non-adjacent residues	10 – 11	2
	Non-adjacent residues	41 – 42	2
	Non-adjacent residues	54 – 55	2
	Non-adjacent residues	64 – 65	2
	Non-adjacent residues	75 – 76	2
	Non-adjacent residues	84 – 85	2
	Non-adjacent residues	94 – 95	2
	Non-adjacent residues	102 – 103	2
	Non-adjacent residues	142 – 143	2
	Non-adjacent residues	149 – 150	2
	Non-adjacent residues	158 – 159	2
	Non-terminal residue	180	1

Sequences

	Sequence		Length	Mass (Da)
	P86231 [UniParc]. Last modified June 15, 2010. Version 1. Checksum: 6C78EA048791E270	FASTA	180	21,097
	10 20 30 40 50 60 MFHLRTCAAK SVHKSWDIFF RNTNAGAPPG TAYQSPLSLS RLGFYGLHES DLDKSTRFEE 70 80 90 100 110 120 FLQRGRLNVL ANVIRYHLGM YHRRSSPYPT DVARICEEAF TRRQILLPFR KPLIVFTPKS 130 140 150 160 170 180 LLRHPEARTS FDEMLPGTHF QRVYYDLTRA KPVWYAGRKT HLTELQRFLD TAFDLDAFKK

References

[1]

"Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa." Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S. Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P86231.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR011603. 2oxoglutarate_DH_E1. [Graphical view]
PANTHER	PTHR23152. PTHR23152. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_MESAU

Accession

Primary (citable) accession number: P86231

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 15, 2010
Last sequence update:	June 15, 2010
Last modified:	October 3, 2012
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program