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P86231

- ODO1_MESAU

UniProt

P86231 - ODO1_MESAU

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Protein
2-oxoglutarate dehydrogenase, mitochondrial
Gene
OGDH
Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.By similarity

Cofactori

Thiamine pyrophosphate By similarity.By similarity

Enzyme regulationi

Catabolite repressed By similarity.By similarity

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase, mitochondrial (EC:1.2.4.2)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name:
OGDC-E1
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:OGDH
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

Mitochondrion matrix By similarity By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›180›1802-oxoglutarate dehydrogenase, mitochondrial
PRO_0000394738Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141N6-succinyllysine By similarity

Proteomic databases

PRIDEiP86231.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR011603. 2oxoglutarate_DH_E1.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.

Sequencei

Sequence statusi: Fragments.

P86231-1 [UniParc]FASTAAdd to Basket

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MFHLRTCAAK SVHKSWDIFF RNTNAGAPPG TAYQSPLSLS RLGFYGLHES    50
DLDKSTRFEE FLQRGRLNVL ANVIRYHLGM YHRRSSPYPT DVARICEEAF 100
TRRQILLPFR KPLIVFTPKS LLRHPEARTS FDEMLPGTHF QRVYYDLTRA 150
KPVWYAGRKT HLTELQRFLD TAFDLDAFKK 180
Length:180
Mass (Da):21,097
Last modified:June 15, 2010 - v1
Checksum:i6C78EA048791E270
GO

Non-adjacent residues

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-adjacent residuesi10 – 112
Non-adjacent residuesi41 – 422
Non-adjacent residuesi54 – 552
Non-adjacent residuesi64 – 652
Non-adjacent residuesi75 – 762
Non-adjacent residuesi84 – 852
Non-adjacent residuesi94 – 952
Non-adjacent residuesi102 – 1032
Non-adjacent residuesi142 – 1432
Non-adjacent residuesi149 – 1502
Non-adjacent residuesi158 – 1592

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei180 – 1801

Cross-referencesi

3D structure databases

ModBasei Search...

Proteomic databases

PRIDEi P86231.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR011603. 2oxoglutarate_DH_E1.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
    Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
    Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiODO1_MESAU
AccessioniPrimary (citable) accession number: P86231
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: June 11, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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