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P86231

- ODO1_MESAU

UniProt

P86231 - ODO1_MESAU

Protein

2-oxoglutarate dehydrogenase, mitochondrial

Gene

OGDH

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.By similarity

    Cofactori

    Thiamine pyrophosphate.By similarity

    Enzyme regulationi

    Catabolite repressed.By similarity

    GO - Molecular functioni

    1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Thiamine pyrophosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-oxoglutarate dehydrogenase, mitochondrialBy similarity (EC:1.2.4.2)
    Alternative name(s):
    2-oxoglutarate dehydrogenase complex component E1By similarity
    Short name:
    OGDC-E1By similarity
    Alpha-ketoglutarate dehydrogenaseBy similarity
    Gene namesi
    Name:OGDHBy similarity
    OrganismiMesocricetus auratus (Golden hamster)
    Taxonomic identifieri10036 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›180›1802-oxoglutarate dehydrogenase, mitochondrialPRO_0000394738Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei14 – 141N6-succinyllysineBy similarity

    Proteomic databases

    PRIDEiP86231.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha-ketoglutarate dehydrogenase family.Sequence Analysis

    Family and domain databases

    InterProiIPR011603. 2oxoglutarate_DH_E1.
    [Graphical view]
    PANTHERiPTHR23152. PTHR23152. 1 hit.

    Sequencei

    Sequence statusi: Fragments.

    P86231-1 [UniParc]FASTAAdd to Basket

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    MFHLRTCAAK SVHKSWDIFF RNTNAGAPPG TAYQSPLSLS RLGFYGLHES    50
    DLDKSTRFEE FLQRGRLNVL ANVIRYHLGM YHRRSSPYPT DVARICEEAF 100
    TRRQILLPFR KPLIVFTPKS LLRHPEARTS FDEMLPGTHF QRVYYDLTRA 150
    KPVWYAGRKT HLTELQRFLD TAFDLDAFKK 180
    Length:180
    Mass (Da):21,097
    Last modified:June 15, 2010 - v1
    Checksum:i6C78EA048791E270
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-adjacent residuesi10 – 112Curated
    Non-adjacent residuesi41 – 422Curated
    Non-adjacent residuesi54 – 552Curated
    Non-adjacent residuesi64 – 652Curated
    Non-adjacent residuesi75 – 762Curated
    Non-adjacent residuesi84 – 852Curated
    Non-adjacent residuesi94 – 952Curated
    Non-adjacent residuesi102 – 1032Curated
    Non-adjacent residuesi142 – 1432Curated
    Non-adjacent residuesi149 – 1502Curated
    Non-adjacent residuesi158 – 1592Curated
    Non-terminal residuei180 – 1801

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P86231.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR011603. 2oxoglutarate_DH_E1.
    [Graphical view ]
    PANTHERi PTHR23152. PTHR23152. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
      Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
      Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiODO1_MESAU
    AccessioniPrimary (citable) accession number: P86231
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3