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Protein

2-oxoglutarate dehydrogenase, mitochondrial

Gene

OGDH

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.By similarity

Cofactori

thiamine diphosphateBy similarity

Enzyme regulationi

Catabolite repressed.By similarity

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase, mitochondrialBy similarity (EC:1.2.4.2)
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1By similarity
Short name:
OGDC-E1By similarity
Alpha-ketoglutarate dehydrogenaseBy similarity
Gene namesi
Name:OGDHBy similarity
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›180›1802-oxoglutarate dehydrogenase, mitochondrialPRO_0000394738Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141N6-succinyllysineBy similarity

Proteomic databases

PRIDEiP86231.

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.Sequence Analysis

Family and domain databases

InterProiIPR011603. 2oxoglutarate_DH_E1.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.

Sequencei

Sequence statusi: Fragments.

P86231-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFHLRTCAAK SVHKSWDIFF RNTNAGAPPG TAYQSPLSLS RLGFYGLHES
60 70 80 90 100
DLDKSTRFEE FLQRGRLNVL ANVIRYHLGM YHRRSSPYPT DVARICEEAF
110 120 130 140 150
TRRQILLPFR KPLIVFTPKS LLRHPEARTS FDEMLPGTHF QRVYYDLTRA
160 170 180
KPVWYAGRKT HLTELQRFLD TAFDLDAFKK
Length:180
Mass (Da):21,097
Last modified:June 15, 2010 - v1
Checksum:i6C78EA048791E270
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-adjacent residuesi10 – 112Curated
Non-adjacent residuesi41 – 422Curated
Non-adjacent residuesi54 – 552Curated
Non-adjacent residuesi64 – 652Curated
Non-adjacent residuesi75 – 762Curated
Non-adjacent residuesi84 – 852Curated
Non-adjacent residuesi94 – 952Curated
Non-adjacent residuesi102 – 1032Curated
Non-adjacent residuesi142 – 1432Curated
Non-adjacent residuesi149 – 1502Curated
Non-adjacent residuesi158 – 1592Curated
Non-terminal residuei180 – 1801

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP86231.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR011603. 2oxoglutarate_DH_E1.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
    Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
    Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiODO1_MESAU
AccessioniPrimary (citable) accession number: P86231
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: January 7, 2015
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.