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P86231 (ODO1_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase, mitochondrial

EC=1.2.4.2
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E1
Short name=OGDC-E1
Alpha-ketoglutarate dehydrogenase
Gene names
Name:OGDH
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length180 AA.
Sequence statusFragments.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. UniProtKB Q02218

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. UniProtKB Q02218

Cofactor

Thiamine pyrophosphate By similarity. UniProtKB Q02218

Enzyme regulation

Catabolite repressed By similarity. UniProtKB Q02218

Subcellular location

Mitochondrion matrix By similarity UniProtKB Q02218.

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentMitochondrion
   LigandThiamine pyrophosphate
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-KW

tricarboxylic acid cycle

Inferred from electronic annotation. Source: InterPro

   Cellular_componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionoxoglutarate dehydrogenase (succinyl-transferring) activity

Inferred from electronic annotation. Source: UniProtKB-EC

thiamine pyrophosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›180›1802-oxoglutarate dehydrogenase, mitochondrial
PRO_0000394738

Amino acid modifications

Modified residue141N6-succinyllysine By similarity

Experimental info

Non-adjacent residues10 – 112
Non-adjacent residues41 – 422
Non-adjacent residues54 – 552
Non-adjacent residues64 – 652
Non-adjacent residues75 – 762
Non-adjacent residues84 – 852
Non-adjacent residues94 – 952
Non-adjacent residues102 – 1032
Non-adjacent residues142 – 1432
Non-adjacent residues149 – 1502
Non-adjacent residues158 – 1592
Non-terminal residue1801

Sequences

Sequence LengthMass (Da)Tools
P86231 [UniParc].

Last modified June 15, 2010. Version 1.
Checksum: 6C78EA048791E270

FASTA18021,097
        10         20         30         40         50         60 
MFHLRTCAAK SVHKSWDIFF RNTNAGAPPG TAYQSPLSLS RLGFYGLHES DLDKSTRFEE 

        70         80         90        100        110        120 
FLQRGRLNVL ANVIRYHLGM YHRRSSPYPT DVARICEEAF TRRQILLPFR KPLIVFTPKS 

       130        140        150        160        170        180 
LLRHPEARTS FDEMLPGTHF QRVYYDLTRA KPVWYAGRKT HLTELQRFLD TAFDLDAFKK 

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References

[1]"Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP86231.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR011603. 2oxoglutarate_DH_E1.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_MESAU
AccessionPrimary (citable) accession number: P86231
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: June 11, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families