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P86222 (ODPB_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Short name=PDHE1-B
EC=1.2.4.1
Gene names
Name:PDHB
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length211 AA.
Sequence statusFragments.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2, and thereby links the glycolytic pathway to the tricarboxylic cycle By similarity. UniProtKB P11177

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. UniProtKB P11177

Cofactor

Thiamine pyrophosphate By similarity. UniProtKB P11177

Subunit structure

Heterotetramer of two PDHA1 and two PDHB subunits. The heterotetramer interacts with DLAT, and is part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules By similarity.

Subcellular location

Mitochondrion matrix By similarity UniProtKB P11177.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›211›211Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
PRO_0000394306

Amino acid modifications

Modified residue311Phosphotyrosine By similarity UniProtKB Q9D051

Experimental info

Non-adjacent residues35 – 362
Non-adjacent residues133 – 1342
Non-terminal residue11
Non-terminal residue2111

Sequences

Sequence LengthMass (Da)Tools
P86222 [UniParc].

Last modified May 18, 2010. Version 1.
Checksum: 0F24DCE9BB09B3E7

FASTA21123,010
        10         20         30         40         50         60 
EAINQGMDEE LERDEKVFLL GEEVAQYDGA YKVSRTYYMS AGLQPVPIVF RGPNGASAGV 

        70         80         90        100        110        120 
AAQHSQCFAA WYGHCPGLKV VSPWNSEDAK GLIKSAIRDD NPVVMLENEL MYGVAFELPT 

       130        140        150        160        170        180 
EAQSKDFLIP IGKEGIECEV INLRTIRPMD IEAIEASVMK TNHLVTVEGG WPQFGVGAEI 

       190        200        210 
CARIMEGPAF NFLDAPAVRV TGADVPMPYA K 

« Hide

References

[1]"Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

3D structure databases

ProteinModelPortalP86222.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP86222.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.920. 1 hit.
InterProIPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view]
PfamPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SUPFAMSSF52922. SSF52922. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODPB_MESAU
AccessionPrimary (citable) accession number: P86222
Entry history
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: October 16, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program