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P86217

- NDUS3_MESAU

UniProt

P86217 - NDUS3_MESAU

Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

Gene

NDUFS3

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.By similarity

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialBy similarity (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    Complex I-30kDBy similarity
    Short name:
    CI-30kDBy similarity
    NADH-ubiquinone oxidoreductase 30 kDa subunitBy similarity
    Gene namesi
    Name:NDUFS3By similarity
    OrganismiMesocricetus auratus (Golden hamster)
    Taxonomic identifieri10036 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

    Subcellular locationi

    Mitochondrion inner membrane By similarity
    Note: Matrix and cytoplasmic side of the mitochondrial inner membrane.By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›94›94NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialPRO_0000394305Add
    BLAST

    Proteomic databases

    PRIDEiP86217.

    Interactioni

    Subunit structurei

    Mammalian complex I is composed of 45 different subunits. Interacts with NDUFAF3 By similarity.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 30 kDa subunit family.Sequence Analysis

    Family and domain databases

    InterProiIPR001268. NADH_UbQ_OxRdtase_30kDa_su.
    [Graphical view]
    PfamiPF00329. Complex1_30kDa. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragments.

    P86217-1 [UniParc]FASTAAdd to Basket

    « Hide

    VCCRGLLGAA SVGRQNRFEI VYNLLSLREV WDMFGVFFFN HPDLRILTDY   50
    GFEGHPFRKY DDEVKRVVAE PVELAQEFRK FDLNSPWEAF PAYR 94
    Length:94
    Mass (Da):11,107
    Last modified:May 18, 2010 - v1
    Checksum:i13BC4321646C6418
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-adjacent residuesi14 – 152Curated
    Non-adjacent residuesi28 – 292Curated
    Non-adjacent residuesi45 – 462Curated
    Non-adjacent residuesi59 – 602Curated
    Non-terminal residuei94 – 941

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P86217.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
    [Graphical view ]
    Pfami PF00329. Complex1_30kDa. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
      Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
      Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiNDUS3_MESAU
    AccessioniPrimary (citable) accession number: P86217
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 18, 2010
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 10 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3