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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

Gene

NDUFS3

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialBy similarity (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-30kDBy similarity
Short name:
CI-30kDBy similarity
NADH-ubiquinone oxidoreductase 30 kDa subunitBy similarity
Gene namesi
Name:NDUFS3By similarity
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

  • Mitochondrion inner membrane By similarity

  • Note: Matrix and cytoplasmic side of the mitochondrial inner membrane.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000394305‹1 – ›94NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialAdd BLAST›94

Proteomic databases

PRIDEiP86217.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits. Interacts with NDUFAF3 (By similarity).By similarity

Structurei

3D structure databases

SMRiP86217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I 30 kDa subunit family.Sequence analysis

Family and domain databases

InterProiView protein in InterPro
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
PfamiView protein in Pfam
PF00329. Complex1_30kDa. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.

Sequencei

Sequence statusi: Fragments.

P86217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VCCRGLLGAA SVGRQNRFEI VYNLLSLREV WDMFGVFFFN HPDLRILTDY
60 70 80 90
GFEGHPFRKY DDEVKRVVAE PVELAQEFRK FDLNSPWEAF PAYR
Length:94
Mass (Da):11,107
Last modified:May 18, 2010 - v1
Checksum:i13BC4321646C6418
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-adjacent residuesi14 – 15Curated2
Non-adjacent residuesi28 – 29Curated2
Non-adjacent residuesi45 – 46Curated2
Non-adjacent residuesi59 – 60Curated2
Non-terminal residuei941

Cross-referencesi

3D structure databases

SMRiP86217.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP86217.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
PfamiView protein in Pfam
PF00329. Complex1_30kDa. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNDUS3_MESAU
AccessioniPrimary (citable) accession number: P86217
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: March 15, 2017
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.