SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P86217

- NDUS3_MESAU

UniProt

P86217 - NDUS3_MESAU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Gene
NDUFS3
Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.By similarity

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-30kD
Short name:
CI-30kD
NADH-ubiquinone oxidoreductase 30 kDa subunit
Gene namesi
Name:NDUFS3
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

Mitochondrion inner membrane By similarity
Note: Matrix and cytoplasmic side of the mitochondrial inner membrane By similarity.By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›94›94NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
PRO_0000394305Add
BLAST

Proteomic databases

PRIDEiP86217.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits. Interacts with NDUFAF3 By similarity.By similarity

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR001268. NADH_UbQ_OxRdtase_30kDa_su.
[Graphical view]
PfamiPF00329. Complex1_30kDa. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragments.

P86217-1 [UniParc]FASTAAdd to Basket

« Hide

VCCRGLLGAA SVGRQNRFEI VYNLLSLREV WDMFGVFFFN HPDLRILTDY   50
GFEGHPFRKY DDEVKRVVAE PVELAQEFRK FDLNSPWEAF PAYR 94
Length:94
Mass (Da):11,107
Last modified:May 18, 2010 - v1
Checksum:i13BC4321646C6418
GO

Non-adjacent residues

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-adjacent residuesi14 – 152
Non-adjacent residuesi28 – 292
Non-adjacent residuesi45 – 462
Non-adjacent residuesi59 – 602

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei94 – 941

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P86217.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
[Graphical view ]
Pfami PF00329. Complex1_30kDa. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
    Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
    Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiNDUS3_MESAU
AccessioniPrimary (citable) accession number: P86217
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: February 19, 2014
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi