P86214 (GSTM5_MESAU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase Mu 5
EC=2.5.1.18

Alternative name(s):
GST class-mu 5

Gene names

Name:

GSTM5

Organism

Mesocricetus auratus (Golden hamster)

Taxonomic identifier

10036 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Mesocricetus

Protein attributes

Sequence length	138 AA.
Sequence status	Fragments.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity. UniProtKB Q9Z1B2
Catalytic activity	RX + glutathione = HX + R-S-glutathione. UniProtKB Q9Z1B2
Subunit structure	Homodimer By similarity. UniProtKB P21266
Subcellular location	Cytoplasm By similarity UniProtKB Q9Z1B2.
Sequence similarities	Belongs to the GST superfamily. Mu family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological_process	glutathione metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutathione transferase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›138	›138	Glutathione S-transferase Mu 5		PRO_0000394302
Regions
	Domain	‹1 – ›71	›71	GST N-terminal UniProtKB Q9Z1B2
	Domain	‹72 – 135	›64	GST C-terminal UniProtKB Q9Z1B2
	Region	6 – 7	2	Glutathione binding By similarity
	Region	39 – 43	5	Glutathione binding By similarity
	Region	52 – 53	2	Glutathione binding By similarity
	Region	65 – 66	2	Glutathione binding By similarity
Experimental info
	Non-adjacent residues	10 – 11	2
	Non-adjacent residues	71 – 72	2
	Non-adjacent residues	85 – 86	2
	Non-adjacent residues	93 – 94	2
	Non-adjacent residues	129 – 130	2
	Non-terminal residue	1	1
	Non-terminal residue	138	1

Sequences

	Sequence		Length	Mass (Da)
	P86214 [UniParc]. Last modified May 18, 2010. Version 1. Checksum: 68C99F8E788423A8	FASTA	138	16,658
	10 20 30 40 50 60 SMVLGYWDIR RMLLEFTDTS YEEKRYICGE APDYDRSQWL DVKFKLDLDF PNLPYLMDGK 70 80 90 100 110 120 NKITQSNAIL RIRVDIMENQ IMDFRQFSLF LGKKLTFVDF LTYDVLDQNR MFEPKCLDEF 130 PNLKAFMCRC FKMPINNK

References

[1]

"Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa." Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S. Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P86214.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR003081. GST_mu. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PRINTS	PR01267. GSTRNSFRASEM.
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTM5_MESAU

Accession

Primary (citable) accession number: P86214

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 18, 2010
Last sequence update:	May 18, 2010
Last modified:	March 6, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program