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P86214 (GSTM5_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase Mu 5

EC=2.5.1.18
Alternative name(s):
GST class-mu 5
Gene names
Name:GSTM5
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length138 AA.
Sequence statusFragments.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity. UniProtKB Q9Z1B2

Catalytic activity

RX + glutathione = HX + R-S-glutathione. UniProtKB Q9Z1B2

Subunit structure

Homodimer By similarity. UniProtKB P21266

Subcellular location

Cytoplasm By similarity UniProtKB Q9Z1B2.

Sequence similarities

Belongs to the GST superfamily. Mu family.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionTransferase
Gene Ontology (GO)
   Biological_processglutathione metabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglutathione transferase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›138›138Glutathione S-transferase Mu 5
PRO_0000394302

Regions

Domain‹1 – ›71›71GST N-terminal UniProtKB Q9Z1B2
Domain‹72 – 135›64GST C-terminal UniProtKB Q9Z1B2
Region6 – 72Glutathione binding By similarity
Region39 – 435Glutathione binding By similarity
Region52 – 532Glutathione binding By similarity
Region65 – 662Glutathione binding By similarity

Experimental info

Non-adjacent residues10 – 112
Non-adjacent residues71 – 722
Non-adjacent residues85 – 862
Non-adjacent residues93 – 942
Non-adjacent residues129 – 1302
Non-terminal residue11
Non-terminal residue1381

Sequences

Sequence LengthMass (Da)Tools
P86214 [UniParc].

Last modified May 18, 2010. Version 1.
Checksum: 68C99F8E788423A8

FASTA13816,658
        10         20         30         40         50         60 
SMVLGYWDIR RMLLEFTDTS YEEKRYICGE APDYDRSQWL DVKFKLDLDF PNLPYLMDGK 

        70         80         90        100        110        120 
NKITQSNAIL RIRVDIMENQ IMDFRQFSLF LGKKLTFVDF LTYDVLDQNR MFEPKCLDEF 

       130 
PNLKAFMCRC FKMPINNK 

« Hide

References

[1]"Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

3D structure databases

ProteinModelPortalP86214.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP86214.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003081. GST_mu.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSPR01267. GSTRNSFRASEM.
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSTM5_MESAU
AccessionPrimary (citable) accession number: P86214
Entry history
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: November 13, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families