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P86203

- NDUS1_MESAU

UniProt

P86203 - NDUS1_MESAU

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Protein
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Gene
NDUFS1
Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized By similarity.By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.By similarity

Cofactori

Binds 1 2Fe-2S cluster per subunit By similarity.By similarity
Binds 2 4Fe-4S clusters per subunit By similarity.By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
    Alternative name(s):
    Complex I-75kD
    Short name:
    CI-75kD
    Gene namesi
    Name:NDUFS1
    OrganismiMesocricetus auratus (Golden hamster)
    Taxonomic identifieri10036 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

    Subcellular locationi

    Mitochondrion inner membrane By similarity
    Note: Matrix and cytoplasmic side of the mitochondrial inner membrane By similarity.By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB-KW
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›190›190NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
    PRO_0000394295Add
    BLAST

    Proteomic databases

    PRIDEiP86203.
    ProMEXiP86203.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits By similarity.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Sequencei

    Sequence statusi: Fragments.

    P86203-1 [UniParc]FASTAAdd to Basket

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    FASEIAGVDD LGTTGRKTES IDVMDAVGSN IVVSTRFAYD GLKRQRLTEP    50
    MVRGLLTYTS WEDALSRFEA PLFNARVALI GSPVDLTYRY DHLGDSPKIA 100
    SQVAALDLGY KPGVEAIRKN PPKLLFLLGA DGGCITRSAT YVNTEGRVAV 150
    TPPGLAREDW KALSEIAGIT LPYDTLDQVR DFYMTDSISR 190
    Length:190
    Mass (Da):20,736
    Last modified:May 18, 2010 - v1
    Checksum:iB3DC03A97075FA9C
    GO

    Non-adjacent residues

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-adjacent residuesi16 – 172
    Non-adjacent residuesi36 – 372
    Non-adjacent residuesi44 – 452
    Non-adjacent residuesi53 – 542
    Non-adjacent residuesi67 – 682
    Non-adjacent residuesi76 – 772
    Non-adjacent residuesi98 – 992
    Non-adjacent residuesi137 – 1382
    Non-adjacent residuesi147 – 1482
    Non-adjacent residuesi161 – 1622
    Non-adjacent residuesi180 – 1812

    Non-terminal residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei190 – 1901

    Cross-referencesi

    3D structure databases

    ModBasei Search...

    Proteomic databases

    PRIDEi P86203.
    ProMEXi P86203.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
      Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
      Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiNDUS1_MESAU
    AccessioniPrimary (citable) accession number: P86203
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 18, 2010
    Last sequence update: May 18, 2010
    Last modified: February 19, 2014
    This is version 10 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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