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P86203 (NDUS1_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

EC=1.6.5.3
EC=1.6.99.3
Alternative name(s):
Complex I-75kD
Short name=CI-75kD
Gene names
Name:NDUFS1
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length190 AA.
Sequence statusFragments.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized By similarity. UniProtKB P15690

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

NADH + acceptor = NAD+ + reduced acceptor. UniProtKB P15690

Cofactor

Binds 1 2Fe-2S cluster per subunit By similarity. UniProtKB P29915

Binds 2 4Fe-4S clusters per subunit By similarity. UniProtKB P29915

Subunit structure

Complex I is composed of 45 different subunits By similarity. UniProtKB P15690

Subcellular location

Mitochondrion inner membrane By similarity. Note: Matrix and cytoplasmic side of the mitochondrial inner membrane By similarity. UniProtKB Q91VD9

Sequence similarities

Belongs to the complex I 75 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›190›190NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
PRO_0000394295

Experimental info

Non-adjacent residues16 – 172
Non-adjacent residues36 – 372
Non-adjacent residues44 – 452
Non-adjacent residues53 – 542
Non-adjacent residues67 – 682
Non-adjacent residues76 – 772
Non-adjacent residues98 – 992
Non-adjacent residues137 – 1382
Non-adjacent residues147 – 1482
Non-adjacent residues161 – 1622
Non-adjacent residues180 – 1812
Non-terminal residue11
Non-terminal residue1901

Sequences

Sequence LengthMass (Da)Tools
P86203 [UniParc].

Last modified May 18, 2010. Version 1.
Checksum: B3DC03A97075FA9C

FASTA19020,736
        10         20         30         40         50         60 
FASEIAGVDD LGTTGRKTES IDVMDAVGSN IVVSTRFAYD GLKRQRLTEP MVRGLLTYTS 

        70         80         90        100        110        120 
WEDALSRFEA PLFNARVALI GSPVDLTYRY DHLGDSPKIA SQVAALDLGY KPGVEAIRKN 

       130        140        150        160        170        180 
PPKLLFLLGA DGGCITRSAT YVNTEGRVAV TPPGLAREDW KALSEIAGIT LPYDTLDQVR 

       190 
DFYMTDSISR 

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References

[1]"Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP86203.
ProMEXP86203.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameNDUS1_MESAU
AccessionPrimary (citable) accession number: P86203
Entry history
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: February 19, 2014
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families