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P86203

- NDUS1_MESAU

UniProt

P86203 - NDUS1_MESAU

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Protein

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Gene
NDUFS1
Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized By similarity.By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
NADH + acceptor = NAD+ + reduced acceptor.By similarity

Cofactori

Binds 1 2Fe-2S cluster per subunit By similarity.By similarity
Binds 2 4Fe-4S clusters per subunit By similarity.By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC:1.6.5.3, EC:1.6.99.3)
Alternative name(s):
Complex I-75kD
Short name:
CI-75kD
Gene namesi
Name:NDUFS1
OrganismiMesocricetus auratus (Golden hamster)
Taxonomic identifieri10036 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Subcellular locationi

Mitochondrion inner membrane By similarity
Note: Matrix and cytoplasmic side of the mitochondrial inner membrane By similarity.By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-SubCell
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›190›190NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialPRO_0000394295Add
BLAST

Proteomic databases

PRIDEiP86203.
ProMEXiP86203.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits By similarity.By similarity

Family & Domainsi

Sequence similaritiesi

Sequencei

Sequence statusi: Fragments.

P86203-1 [UniParc]FASTAAdd to Basket

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FASEIAGVDD LGTTGRKTES IDVMDAVGSN IVVSTRFAYD GLKRQRLTEP    50
MVRGLLTYTS WEDALSRFEA PLFNARVALI GSPVDLTYRY DHLGDSPKIA 100
SQVAALDLGY KPGVEAIRKN PPKLLFLLGA DGGCITRSAT YVNTEGRVAV 150
TPPGLAREDW KALSEIAGIT LPYDTLDQVR DFYMTDSISR 190
Length:190
Mass (Da):20,736
Last modified:May 18, 2010 - v1
Checksum:iB3DC03A97075FA9C
GO

Non-adjacent residues

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-adjacent residuesi16 – 172
Non-adjacent residuesi36 – 372
Non-adjacent residuesi44 – 452
Non-adjacent residuesi53 – 542
Non-adjacent residuesi67 – 682
Non-adjacent residuesi76 – 772
Non-adjacent residuesi98 – 992
Non-adjacent residuesi137 – 1382
Non-adjacent residuesi147 – 1482
Non-adjacent residuesi161 – 1622
Non-adjacent residuesi180 – 1812

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei190 – 1901

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P86203.
ProMEXi P86203.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
    Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
    Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiNDUS1_MESAU
AccessioniPrimary (citable) accession number: P86203
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: February 19, 2014
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3