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P86200 (NAGK_MESAU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetyl-D-glucosamine kinase

Short name=N-acetylglucosamine kinase
EC=2.7.1.59
Alternative name(s):
GlcNAc kinase
Gene names
Name:NAGK
OrganismMesocricetus auratus (Golden hamster)
Taxonomic identifier10036 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeMesocricetus

Protein attributes

Sequence length61 AA.
Sequence statusFragments.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Also has ManNAc kinase activity By similarity. UniProtKB Q9QZ08

Catalytic activity

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate. UniProtKB Q9QZ08

Pathway

Amino-sugar metabolism; N-acetylneuraminate degradation.

Subunit structure

Homodimer By similarity. UniProtKB Q9UJ70

Sequence similarities

Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›61›61N-acetyl-D-glucosamine kinase
PRO_0000394398

Sites

Binding site451ATP By similarity UniProtKB Q9UJ70

Amino acid modifications

Modified residue301Phosphotyrosine By similarity UniProtKB Q9UJ70

Experimental info

Non-adjacent residues10 – 112
Non-adjacent residues31 – 322
Non-adjacent residues44 – 452
Non-terminal residue11
Non-terminal residue611

Sequences

Sequence LengthMass (Da)Tools
P86200 [UniParc].

Last modified June 15, 2010. Version 1.
Checksum: F24D4EE847EBDF63

FASTA616,868
        10         20         30         40         50         60 
AGVDPLVPLR QAMFNYFQVP DRLGILTHLY RIAEGAQQGD PLSRSWELLK EGFLLALTQG 


R 

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References

[1]"Glucose-regulated protein precursor (GRP78) and tumor rejection antigen (GP96) are unique to hamster caput epididymal spermatozoa."
Kameshwari D.B., Bhande S., Sundaram C.S., Kota V., Siva A.B., Shivaji S.
Asian J. Androl. 12:344-355(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP86200.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00629.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameNAGK_MESAU
AccessionPrimary (citable) accession number: P86200
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: April 16, 2014
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways