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L-amino-acid oxidase

Aplysia dactylomela (Spotted sea hare)
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli


Catalyzes the oxidative deamination of positively charged L-amino acids L-Lys and L-Arg but not of amino acids L-His, L-Asp or L-Glu. Has antibacterial activity against the Gram-positive bacterium S.aureus (MIC=15 µg/ml). This antibacterial activity is bacteriostatic in the absence of amino acids L-Lys or L-Arg but bactericidal in their presence. The antibacterial effect is largely dependent on H2O2 produced in the oxidative deamination of substrates. Has hemagglutinating activity towards rabbit erythrocytes. Hemagglutinating activity is inhibited by the glycoprotein fetuin, but not by glucose, mannose, galactose, N-acetylglucosamine, N-acetylgalactosamine or sialic acid.2 Publications

Catalytic activityi

An L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2.1 Publication


FAD1 Publication


  1. KM=0.22 mM for L-Lys1 Publication
  2. KM=0.015 mM for L-Arg1 Publication

    pH dependencei

    Optimum pH is 8. More than 50% activity is retained between pH 3 and 12. Inactive at pH 2.1 Publication

    Temperature dependencei

    Activity remains stable after 30 min at 55 degrees Celsius.1 Publication

    GO - Molecular functioni

    GO - Biological processi

    • defense response to bacterium Source: UniProtKB
    • modulation of blood coagulation in other organism Source: UniProtKB
    • oxidation-reduction process Source: UniProtKB


    Molecular functionAntibiotic, Antimicrobial, Hemagglutinin, Oxidoreductase, Toxin
    LigandFAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-amino-acid oxidaseBy similarity (EC: Publication)
    Short name:
    LAAOBy similarity
    Short name:
    LAOBy similarity
    Alternative name(s):
    Dactylomelin-P1 Publication
    OrganismiAplysia dactylomela (Spotted sea hare)
    Taxonomic identifieri144766 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti


    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00004134711 – ›26L-amino-acid oxidaseAdd BLAST›26

    Post-translational modificationi

    Not glycosylated.2 Publications


    Tissue specificityi

    Expressed by the ink gland.1 Publication


    Subunit structurei

    Monomer.1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the flavin monoamine oxidase family.Sequence analysis


    Sequence statusi: Fragment.

    P86163-1 [UniParc]FASTAAdd to basket

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            10         20 
    Mass (Da):2,731
    Last modified:October 19, 2011 - v1

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Non-terminal residuei261 Publication1

    Entry informationi

    Entry nameiOXLA_APLDA
    AccessioniPrimary (citable) accession number: P86163
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: October 19, 2011
    Last modified: November 22, 2017
    This is version 8 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program


    Keywords - Technical termi

    Direct protein sequencing


    1. SIMILARITY comments
      Index of protein domains and families