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P86110

- KKX25_OPICY

UniProt

P86110 - KKX25_OPICY

Protein

Potassium channel toxin kappa-KTx 2.5

Gene
N/A
Organism
Opisthacanthus cayaporum (South American scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Voltage-independently blocks potassium currents on human Kv1.1/KCNA1 (IC50=217 µM), and human Kv1.4/KCNA4 (IC50=71 µM) (expressed in CHO cells).1 Publication

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin kappa-KTx 2.5
    Alternative name(s):
    OcyC8
    OcyKTx6
    OrganismiOpisthacanthus cayaporum (South American scorpion)
    Taxonomic identifieri573324 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaHemiscorpiidaeOpisthacanthus

    Subcellular locationi

    Secreted 2 Publications

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Propeptidei27 – 42162 PublicationsPRO_0000398603Add
    BLAST
    Peptidei43 – 7028Potassium channel toxin kappa-KTx 2.5PRO_0000398136Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi46 ↔ 64By similarity
    Disulfide bondi50 ↔ 60By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.2 Publications

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P86110-1 [UniParc]FASTAAdd to Basket

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    MESSRKSYVL MLFLAFVIMN VCSVSGEPKD GEIAGFEMEE ARYDACVNAC   50
    LEHHPNVREC EEACKNPVPP 70
    Length:70
    Mass (Da):7,823
    Last modified:October 5, 2010 - v1
    Checksum:i152071A7A97408C5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531H → N AA sequence (PubMed:18502464)Curated

    Mass spectrometryi

    Molecular mass is 3132.26 Da from positions 43 - 70. Determined by MALDI. Monoisotopic mass.1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM998750 mRNA. Translation: CAX51396.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FM998750 mRNA. Translation: CAX51396.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum."
      Silva E.C., Camargos T.S., Maranhao A.Q., Silva-Pereira I., Silva L.P., Possani L.D., Schwartz E.F.
      Toxicon 54:252-261(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Venom gland.
    2. Cited for: PROTEIN SEQUENCE OF 43-70, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, SYNTHESIS OF 43-70, DOMAIN, CIRCULAR DICHROISM, MASS SPECTROMETRY.
      Tissue: Venom.
    3. "Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum."
      Schwartz E.F., Camargos T.S., Zamudio F.Z., Silva L.P., Bloch C. Jr., Caixeta F., Schwartz C.A., Possani L.D.
      Toxicon 51:1499-1508(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 43-64, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Venom1 Publication.

    Entry informationi

    Entry nameiKKX25_OPICY
    AccessioniPrimary (citable) accession number: P86110
    Secondary accession number(s): C5J892
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 11 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Miscellaneous

    Has no effect on other potassium channels, on sodium channels, on bacterial growth and on smooth muscle tissue (a known assay to identify possible bradykinin-potentiating peptides).1 Publication

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3