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Protein

Potassium channel toxin kappa-KTx 2.5

Gene
N/A
Organism
Opisthacanthus cayaporum (South American scorpion)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-independently blocks potassium currents on hKv1.1/KCNA1 (IC50=217 µM), and hKv1.4/KCNA4 (IC50=71 µM) (expressed in CHO cells).1 Publication

Miscellaneous

Has no effect on other potassium channels, on sodium channels, on bacterial growth and on smooth muscle tissue (a known assay to identify possible bradykinin-potentiating peptides).1 Publication

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin kappa-KTx 2.51 Publication
Alternative name(s):
OcyC81 Publication
OcyKTx6
OrganismiOpisthacanthus cayaporum (South American scorpion)
Taxonomic identifieri573324 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaHemiscorpiidaeOpisthacanthus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000039860327 – 422 PublicationsAdd BLAST16
PeptideiPRO_000039813643 – 70Potassium channel toxin kappa-KTx 2.51 PublicationAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 64By similarity
Disulfide bondi50 ↔ 60By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.2 Publications

Structurei

3D structure databases

SMRiP86110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Has the structural arrangement of two alpha-helices stabilized by two disulfide bonds (CSalpha/alpha 2(S-S)).By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P86110-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSRKSYVL MLFLAFVIMN VCSVSGEPKD GEIAGFEMEE ARYDACVNAC
60 70
LEHHPNVREC EEACKNPVPP
Length:70
Mass (Da):7,823
Last modified:October 5, 2010 - v1
Checksum:i152071A7A97408C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53H → N AA sequence (PubMed:18502464).Curated1

Mass spectrometryi

Molecular mass is 3132.26 Da from positions 43 - 70. Determined by MALDI. Monoisotopic mass.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FM998750 mRNA. Translation: CAX51396.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKKX25_OPICY
AccessioniPrimary (citable) accession number: P86110
Secondary accession number(s): C5J892
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: May 10, 2017
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families