UniProtKB - P86110 (KKX25_OPICY)
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Protein
Potassium channel toxin kappa-KTx 2.5
Gene
N/A
Organism
Opisthacanthus cayaporum (South American scorpion)
Status
Functioni
Voltage-independently blocks potassium currents on hKv1.1/KCNA1 (IC50=217 µM), and hKv1.4/KCNA4 (IC50=71 µM) (expressed in CHO cells).1 Publication
Miscellaneous
Has no effect on other potassium channels, on sodium channels, on bacterial growth and on smooth muscle tissue (a known assay to identify possible bradykinin-potentiating peptides).1 Publication
Keywordsi
| Molecular function | Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin |
Names & Taxonomyi
| Protein namesi | Recommended name: Potassium channel toxin kappa-KTx 2.51 PublicationAlternative name(s): OcyC81 Publication OcyKTx6 |
| Organismi | Opisthacanthus cayaporum (South American scorpion) |
| Taxonomic identifieri | 573324 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Iurida › Scorpionoidea › Hemiscorpiidae › Opisthacanthus |
Subcellular locationi
- Secreted 2 Publications
GO - Cellular componenti
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
| PropeptideiPRO_0000398603 | 27 – 42 | 2 PublicationsAdd BLAST | 16 | |
| PeptideiPRO_0000398136 | 43 – 70 | Potassium channel toxin kappa-KTx 2.51 PublicationAdd BLAST | 28 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Disulfide bondi | 46 ↔ 64 | By similarity | ||
| Disulfide bondi | 50 ↔ 60 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.2 Publications
Family & Domainsi
Domaini
Has the structural arrangement of two alpha-helices stabilized by two disulfide bonds (CSalpha/alpha 2(S-S)).By similarity
Sequence similaritiesi
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor kappa-KTx family. Kappa-KTx 2 subfamily.Curated
Keywords - Domaini
SignalSequencei
Sequence statusi: Complete.
Sequence processingi: The displayed sequence is further processed into a mature form.
P86110-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESSRKSYVL MLFLAFVIMN VCSVSGEPKD GEIAGFEMEE ARYDACVNAC
60 70
LEHHPNVREC EEACKNPVPP
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sequence conflicti | 53 | H → N AA sequence (PubMed:18502464).Curated | 1 |
Mass spectrometryi
Molecular mass is 3132.26 Da from positions 43 - 70. Determined by MALDI. Monoisotopic mass.1 Publication
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FM998750 mRNA. Translation: CAX51396.1. |
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |
Entry informationi
| Entry namei | KKX25_OPICY | |
| Accessioni | P86110Primary (citable) accession number: P86110 Secondary accession number(s): C5J892 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 5, 2010 |
| Last sequence update: | October 5, 2010 | |
| Last modified: | May 10, 2017 | |
| This is version 15 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Animal Toxin Annotation Program | |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families
