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P86110

- KKX25_OPICY

UniProt

P86110 - KKX25_OPICY

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Protein

Potassium channel toxin kappa-KTx 2.5

Gene
N/A
Organism
Opisthacanthus cayaporum (South American scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Voltage-independently blocks potassium currents on human Kv1.1/KCNA1 (IC50=217 µM), and human Kv1.4/KCNA4 (IC50=71 µM) (expressed in CHO cells).1 Publication

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin kappa-KTx 2.5
Alternative name(s):
OcyC8
OcyKTx6
OrganismiOpisthacanthus cayaporum (South American scorpion)
Taxonomic identifieri573324 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesIuridaScorpionoideaHemiscorpiidaeOpisthacanthus

Subcellular locationi

Secreted 2 Publications

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Propeptidei27 – 42162 PublicationsPRO_0000398603Add
BLAST
Peptidei43 – 7028Potassium channel toxin kappa-KTx 2.5PRO_0000398136Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 64By similarity
Disulfide bondi50 ↔ 60By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.2 Publications

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P86110-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESSRKSYVL MLFLAFVIMN VCSVSGEPKD GEIAGFEMEE ARYDACVNAC
60 70
LEHHPNVREC EEACKNPVPP
Length:70
Mass (Da):7,823
Last modified:October 5, 2010 - v1
Checksum:i152071A7A97408C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531H → N AA sequence (PubMed:18502464)Curated

Mass spectrometryi

Molecular mass is 3132.26 Da from positions 43 - 70. Determined by MALDI. Monoisotopic mass.1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM998750 mRNA. Translation: CAX51396.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FM998750 mRNA. Translation: CAX51396.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum."
    Silva E.C., Camargos T.S., Maranhao A.Q., Silva-Pereira I., Silva L.P., Possani L.D., Schwartz E.F.
    Toxicon 54:252-261(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom gland.
  2. Cited for: PROTEIN SEQUENCE OF 43-70, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, SYNTHESIS OF 43-70, DOMAIN, CIRCULAR DICHROISM, MASS SPECTROMETRY.
    Tissue: Venom.
  3. "Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum."
    Schwartz E.F., Camargos T.S., Zamudio F.Z., Silva L.P., Bloch C. Jr., Caixeta F., Schwartz C.A., Possani L.D.
    Toxicon 51:1499-1508(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 43-64, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Venom1 Publication.

Entry informationi

Entry nameiKKX25_OPICY
AccessioniPrimary (citable) accession number: P86110
Secondary accession number(s): C5J892
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

Has no effect on other potassium channels, on sodium channels, on bacterial growth and on smooth muscle tissue (a known assay to identify possible bradykinin-potentiating peptides).1 Publication

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3