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Protein

Inward rectifier potassium channel 13

Gene

Kcnj13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei149Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Recommended name:
Inward rectifier potassium channel 13By similarity
Alternative name(s):
Inward rectifier K(+) channel Kir7.1By similarity
Potassium channel, inwardly rectifying subfamily J member 13Imported
Gene namesi
Name:Kcnj13Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3781032. Kcnj13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 53CytoplasmicBy similarityAdd BLAST53
Transmembranei54 – 78Helical; Name=M1By similarityAdd BLAST25
Topological domaini79 – 105ExtracellularBy similarityAdd BLAST27
Intramembranei106 – 117Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei118 – 124Pore-formingBy similarity7
Topological domaini125 – 133ExtracellularBy similarity9
Transmembranei134 – 155Helical; Name=M2By similarityAdd BLAST22
Topological domaini156 – 360CytoplasmicBy similarityAdd BLAST205

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003551421 – 360Inward rectifier potassium channel 13Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei287Phosphoserine; by PKABy similarity1

Post-translational modificationi

Phosphorylation at Ser-287 by PKA increases ionic currents.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP86046.
PeptideAtlasiP86046.
PRIDEiP86046.

PTM databases

iPTMnetiP86046.
PhosphoSitePlusiP86046.

Expressioni

Gene expression databases

BgeeiENSMUSG00000079436.
ExpressionAtlasiP86046. baseline and differential.
GenevisibleiP86046. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108838.

Structurei

3D structure databases

ProteinModelPortaliP86046.
SMRiP86046.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi119 – 124Selectivity filterBy similarity6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
GeneTreeiENSGT00830000128392.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiP86046.
KOiK05006.
OMAiSSEECPF.
OrthoDBiEOG091G0DOU.
PhylomeDBiP86046.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiView protein in InterPro
IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
IPR008062. KCNJ13.
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF70. PTHR11767:SF70. 1 hit.
PfamiView protein in Pfam
PF01007. IRK. 1 hit.
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01679. KIR7CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

P86046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSNCKVNA PLLSQRHRRM VTKDGHSTLQ MDGAQRGLVY LRDAWGILMD
60 70 80 90 100
MRWRWMMLVF SASFVVHWLV FAVLWYAVAE MNGDLEIDHD VPPENHTICV
110 120 130 140 150
KHITSFTAAF SFSLETQLTI GYGTMFPSGD CPSAIALLAI QMLLGLMLEA
160 170 180 190 200
FITGAFVAKI ARPKNRAFSI RFTDLAVVAH KDGKPNLIFQ VANTRPSPLT
210 220 230 240 250
NVRVSAVLYQ ERENGELYQT SVDFHLDGIS SEECPFFIFP LTYYHTISPS
260 270 280 290 300
SPLATLLQHE TPPHFELVVF LSAMQEGTGE ICQRRTSYLP SEIMLHHRFA
310 320 330 340 350
ALMTRGSKGE YQVKMENFDK TVPEHPTPVV SKSPHRTDLD IHINGQSIDN
360
FQIAETGLTE
Length:360
Mass (Da):40,565
Last modified:November 25, 2008 - v1
Checksum:i9D2107FB5C59C11D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157811 Genomic DNA. No translation available.
CCDSiCCDS35653.1.
RefSeqiNP_001103697.1. NM_001110227.2.
UniGeneiMm.443539.

Genome annotation databases

EnsembliENSMUST00000113212; ENSMUSP00000108838; ENSMUSG00000079436.
GeneIDi100040591.
KEGGimmu:100040591.
UCSCiuc007bwu.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiKCJ13_MOUSE
AccessioniPrimary (citable) accession number: P86046
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: August 30, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families