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Protein

Inward rectifier potassium channel 13

Gene

Kcnj13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei149 – 1491Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Inward rectifier potassium channel 13By similarity
Alternative name(s):
Inward rectifier K(+) channel Kir7.1By similarity
Potassium channel, inwardly rectifying subfamily J member 13Imported
Gene namesi
Name:Kcnj13Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3781032. Kcnj13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5353CytoplasmicBy similarityAdd
BLAST
Transmembranei54 – 7825Helical; Name=M1By similarityAdd
BLAST
Topological domaini79 – 10527ExtracellularBy similarityAdd
BLAST
Intramembranei106 – 11712Helical; Pore-forming; Name=H5By similarityAdd
BLAST
Intramembranei118 – 1247Pore-formingBy similarity
Topological domaini125 – 1339ExtracellularBy similarity
Transmembranei134 – 15522Helical; Name=M2By similarityAdd
BLAST
Topological domaini156 – 360205CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360Inward rectifier potassium channel 13PRO_0000355142Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei287 – 2871Phosphoserine; by PKABy similarity

Post-translational modificationi

Phosphorylation at Ser-287 by PKA increases ionic currents.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP86046.
PaxDbiP86046.
PeptideAtlasiP86046.
PRIDEiP86046.

PTM databases

iPTMnetiP86046.
PhosphoSiteiP86046.

Expressioni

Gene expression databases

BgeeiP86046.
ExpressionAtlasiP86046. baseline and differential.
GenevisibleiP86046. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108838.

Structurei

3D structure databases

ProteinModelPortaliP86046.
SMRiP86046. Positions 19-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi119 – 1246Selectivity filterBy similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
GeneTreeiENSGT00830000128392.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiP86046.
KOiK05006.
OMAiASFVVHW.
OrthoDBiEOG7NW69K.
PhylomeDBiP86046.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
IPR008062. KCNJ13.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF3. PTHR11767:SF3. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01679. KIR7CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

P86046-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSNCKVNA PLLSQRHRRM VTKDGHSTLQ MDGAQRGLVY LRDAWGILMD
60 70 80 90 100
MRWRWMMLVF SASFVVHWLV FAVLWYAVAE MNGDLEIDHD VPPENHTICV
110 120 130 140 150
KHITSFTAAF SFSLETQLTI GYGTMFPSGD CPSAIALLAI QMLLGLMLEA
160 170 180 190 200
FITGAFVAKI ARPKNRAFSI RFTDLAVVAH KDGKPNLIFQ VANTRPSPLT
210 220 230 240 250
NVRVSAVLYQ ERENGELYQT SVDFHLDGIS SEECPFFIFP LTYYHTISPS
260 270 280 290 300
SPLATLLQHE TPPHFELVVF LSAMQEGTGE ICQRRTSYLP SEIMLHHRFA
310 320 330 340 350
ALMTRGSKGE YQVKMENFDK TVPEHPTPVV SKSPHRTDLD IHINGQSIDN
360
FQIAETGLTE
Length:360
Mass (Da):40,565
Last modified:November 25, 2008 - v1
Checksum:i9D2107FB5C59C11D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157811 Genomic DNA. No translation available.
CCDSiCCDS35653.1.
RefSeqiNP_001103697.1. NM_001110227.2.
UniGeneiMm.443539.

Genome annotation databases

EnsembliENSMUST00000113212; ENSMUSP00000108838; ENSMUSG00000079436.
GeneIDi100040591.
KEGGimmu:100040591.
UCSCiuc007bwu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157811 Genomic DNA. No translation available.
CCDSiCCDS35653.1.
RefSeqiNP_001103697.1. NM_001110227.2.
UniGeneiMm.443539.

3D structure databases

ProteinModelPortaliP86046.
SMRiP86046. Positions 19-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108838.

PTM databases

iPTMnetiP86046.
PhosphoSiteiP86046.

Proteomic databases

MaxQBiP86046.
PaxDbiP86046.
PeptideAtlasiP86046.
PRIDEiP86046.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113212; ENSMUSP00000108838; ENSMUSG00000079436.
GeneIDi100040591.
KEGGimmu:100040591.
UCSCiuc007bwu.2. mouse.

Organism-specific databases

CTDi3769.
MGIiMGI:3781032. Kcnj13.

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
GeneTreeiENSGT00830000128392.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiP86046.
KOiK05006.
OMAiASFVVHW.
OrthoDBiEOG7NW69K.
PhylomeDBiP86046.
TreeFamiTF313676.

Miscellaneous databases

PROiP86046.
SOURCEiSearch...

Gene expression databases

BgeeiP86046.
ExpressionAtlasiP86046. baseline and differential.
GenevisibleiP86046. MM.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR013518. K_chnl_inward-rec_Kir_cyto.
IPR008062. KCNJ13.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF3. PTHR11767:SF3. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01679. KIR7CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiKCJ13_MOUSE
AccessioniPrimary (citable) accession number: P86046
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: July 6, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.