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Protein

Hylin-a1

Gene
N/A
Organism
Hypsiboas albopunctatus (Spotted tree frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has antibacterial activity against the Gram-positive bacteria S.aureus ATCC 25926 (MIC=8 µM), E.faecalis ATCC 29212 (MIC=16 µM), and B.subtilis ATCC 19659 (MIC=8 µM). Has a less potent antibacterial activity against the Gram-negative bacteria E.coli ATCC 25922 (MIC=32 µM), and P.aeruginosa ATCC 27853 (MIC=64 µM). Has antifungal activity against C.albicans ATCC 90028 (MIC=16.7 µM), C.krusei ATCC 6258 (MIC=16.7 µM), C.parapsilosis ATCC 22019 (MIC=67 µM), and C.neoformans ATCC 90012 (MIC=33.5 µM). Has hemolytic activity against human erythrocytes (HC50=18 µM).1 Publication

GO - Biological processi

Keywordsi

Molecular functionAmphibian defense peptide, Antibiotic, Antimicrobial, Fungicide
Biological processCytolysis, Hemolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Hylin-a1
Short name:
Hy-a11 Publication
OrganismiHypsiboas albopunctatus (Spotted tree frog)
Taxonomic identifieri279985 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaeHylinaeCophomantiniHypsiboas

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00003714551 – 18Hylin-a1Add BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18Lysine amide1 Publication1

Keywords - PTMi

Amidation

Expressioni

Tissue specificityi

Expressed by the skin glands.Curated

Structurei

Secondary structure

118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 17Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N0ONMR-A1-18[»]
5J6TNMR-A1-18[»]
5J6VNMR-A1-18[»]
5J6WNMR-A1-18[»]
SMRiP85982
ModBaseiSearch...
MobiDBiSearch...

Sequencei

Sequence statusi: Complete.

Length:18
Mass (Da):1,865
Last modified:May 5, 2009 - v1
Checksum:i9832F0ED0D11508A
GO

Mass spectrometryi

Molecular mass is 1864.37 Da from positions 1 - 18. Determined by MALDI. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiALBO1_HYPAB
AccessioniPrimary (citable) accession number: P85982
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: July 5, 2017
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

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