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P85981 (TI_VERHE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 18, 2012. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Trypsin inhibitor
Short name=VhTI
OrganismVeronica hederifolia (Ivy-leaved speedwell)
Taxonomic identifier202477 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Lamiales › Plantaginaceae › Veroniceae › Veronica

Protein attributes

Sequence length34 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits trypsin. Ref.1

Subcellular location

Secreted.

Miscellaneous

Differs dramatically in structure from all previously described families of trypsin inhibitors. Consists of a helix-loop-helix motif with two alpha-helices tightly associated by two disulfide bonds. Ref.1

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionProtease inhibitor
Serine protease inhibitor
   PTMDisulfide bond
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionserine-type endopeptidase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3434Trypsin inhibitor
PRO_0000351204

Sites

Site15 – 162Reactive bond for trypsin Ref.1

Amino acid modifications

Disulfide bond7 ↔ 29 Ref.1
Disulfide bond11 ↔ 25 Ref.1

Secondary structure

1 ..... 34
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P85981 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: BD6BB312733CCE21

FASTA344,050
        10         20         30 
NTDPEQCKVM CYAQRHSSPE LLRRCLDNCE KEHD

« Hide

References

[1]"An unusual helix-turn-helix protease inhibitory motif in a novel trypsin inhibitor from seeds of Veronica (Veronica hederifolia L.)."
Conners R., Konarev A.V., Forsyth J., Lovegrove A., Marsh J., Joseph-Horne T., Shewry P., Brady R.L.
J. Biol. Chem. 282:27760-27768(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, REACTIVE BOND, DISULFIDE BONDS, X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) IN COMPLEX WITH BOVINE TRYPSIN.
Tissue: Seed.

Cross-references

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CMYX-ray2.25B1-34[»]
2PLXX-ray1.56B6-31[»]
ModBaseSearch...

Protein family/group databases

MEROPSI73.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Other

EvolutionaryTraceP85981.

Entry information

Entry nameTI_VERHE
AccessionPrimary (citable) accession number: P85981
Entry history
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: September 23, 2008
Last modified: April 18, 2012
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

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