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P85981

- TI_VERHE

UniProt

P85981 - TI_VERHE

Protein

Trypsin inhibitor

Gene
N/A
Organism
Veronica hederifolia (Ivy-leaved speedwell)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Inhibits trypsin.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei15 – 162Reactive bond for trypsin1 Publication

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI73.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trypsin inhibitor1 Publication
    Short name:
    VhTI1 Publication
    OrganismiVeronica hederifolia (Ivy-leaved speedwell)
    Taxonomic identifieri202477 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesPlantaginaceaeVeroniceaeVeronicaCochlidiosperma

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3434Trypsin inhibitorPRO_0000351204Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi7 ↔ 291 Publication
    Disulfide bondi11 ↔ 251 Publication

    Keywords - PTMi

    Disulfide bond

    Structurei

    Secondary structure

    1
    34
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 137
    Helixi19 – 2911

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CMYX-ray2.25B1-34[»]
    2PLXX-ray1.56B6-31[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP85981.

    Sequencei

    Sequence statusi: Complete.

    P85981-1 [UniParc]FASTAAdd to Basket

    « Hide

    NTDPEQCKVM CYAQRHSSPE LLRRCLDNCE KEHD                    34
    Length:34
    Mass (Da):4,050
    Last modified:September 23, 2008 - v1
    Checksum:iBD6BB312733CCE21
    GO

    Cross-referencesi

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CMY X-ray 2.25 B 1-34 [» ]
    2PLX X-ray 1.56 B 6-31 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I73.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P85981.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "An unusual helix-turn-helix protease inhibitory motif in a novel trypsin inhibitor from seeds of Veronica (Veronica hederifolia L.)."
      Conners R., Konarev A.V., Forsyth J., Lovegrove A., Marsh J., Joseph-Horne T., Shewry P., Brady R.L.
      J. Biol. Chem. 282:27760-27768(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, REACTIVE BOND, DISULFIDE BONDS, X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) IN COMPLEX WITH BOVINE TRYPSIN.
      Tissue: Seed1 Publication.

    Entry informationi

    Entry nameiTI_VERHE
    AccessioniPrimary (citable) accession number: P85981
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Differs dramatically in structure from all previously described families of trypsin inhibitors. Consists of a helix-loop-helix motif with two alpha-helices tightly associated by two disulfide bonds.1 Publication

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3