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P85973

- PNPH_RAT

UniProt

P85973 - PNPH_RAT

Protein

Purine nucleoside phosphorylase

Gene

Pnp

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.By similarity

    Catalytic activityi

    Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. purine-nucleoside phosphorylase activity Source: RGD

    GO - Biological processi

    1. purine-containing compound salvage Source: RGD
    2. purine nucleoside metabolic process Source: RGD

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00606.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Purine nucleoside phosphorylaseBy similarity (EC:2.4.2.1)
    Short name:
    PNPBy similarity
    Alternative name(s):
    Inosine phosphorylaseBy similarity
    Inosine-guanosine phosphorylase
    Gene namesi
    Name:Pnp
    Synonyms:Np
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1597189. Pnp.

    Subcellular locationi

    Cytoplasmcytoskeleton 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. cytoskeleton Source: UniProtKB-SubCell
    3. extracellular region Source: RGD
    4. nucleus Source: RGD

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Purine nucleoside phosphorylasePRO_0000349126Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP85973.
    PRIDEiP85973.

    2D gel databases

    World-2DPAGE0004:P85973.

    Expressioni

    Gene expression databases

    GenevestigatoriP85973.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP85973.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family.Sequence Analysis

    Phylogenomic databases

    eggNOGiCOG0005.
    HOGENOMiHOG000045183.
    HOVERGENiHBG002460.
    KOiK03783.
    PhylomeDBiP85973.
    TreeFamiTF300049.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    InterProiIPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
    IPR011268. Purine_phosphorylase.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000477. PurNPase. 1 hit.
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01700. PNPH. 1 hit.
    TIGR01697. PNPH-PUNA-XAPA. 1 hit.
    PROSITEiPS01240. PNP_MTAP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P85973-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENEFTYEDY QRTAEWLRSH TKHRPQVAVI CGSGLGGLTA KLTQPQAFDY    50
    NEIPNFPQST VQGHAGRLVF GFLNGRSCVM MQGRFHMYEG YSLSKVTFPV 100
    RVFHLLGVDT LVVTNAAGGL NPKFEVGDIM LIRDHINLPG FCGQNPLRGP 150
    NDERFGVRFP AMSDAYDRDM RQKAFNAWKQ MGEQRELQEG TYIMSAGPTF 200
    ETVAESCLLR MLGADAVGMS TVPEVIVARH CGLRVFGFSL ITNKVVMDYN 250
    NLEKASHQEV LEAGKAAAQK LEQFVSILME SIPPRERAN 289
    Length:289
    Mass (Da):32,302
    Last modified:September 2, 2008 - v1
    Checksum:i004486E55848749B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH474040 Genomic DNA. Translation: EDL88431.1.
    RefSeqiXP_006251919.1. XM_006251857.1.
    UniGeneiRn.2738.

    Genome annotation databases

    GeneIDi290029.
    KEGGirno:290029.
    UCSCiRGD:1597189. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH474040 Genomic DNA. Translation: EDL88431.1 .
    RefSeqi XP_006251919.1. XM_006251857.1.
    UniGenei Rn.2738.

    3D structure databases

    ProteinModelPortali P85973.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2395.

    2D gel databases

    World-2DPAGE 0004:P85973.

    Proteomic databases

    PaxDbi P85973.
    PRIDEi P85973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 290029.
    KEGGi rno:290029.
    UCSCi RGD:1597189. rat.

    Organism-specific databases

    CTDi 4860.
    RGDi 1597189. Pnp.

    Phylogenomic databases

    eggNOGi COG0005.
    HOGENOMi HOG000045183.
    HOVERGENi HBG002460.
    KOi K03783.
    PhylomeDBi P85973.
    TreeFami TF300049.

    Enzyme and pathway databases

    UniPathwayi UPA00606 .

    Gene expression databases

    Genevestigatori P85973.

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    InterProi IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
    IPR011268. Purine_phosphorylase.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000477. PurNPase. 1 hit.
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01700. PNPH. 1 hit.
    TIGR01697. PNPH-PUNA-XAPA. 1 hit.
    PROSITEi PS01240. PNP_MTAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Proteome profile of the mature rat olfactory bulb."
      Maurya D.K., Sundaram C.S., Bhargava P.
      Proteomics 9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiPNPH_RAT
    AccessioniPrimary (citable) accession number: P85973
    Secondary accession number(s): A6KEC5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3