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P85973 (PNPH_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Purine nucleoside phosphorylase

Short name=PNP
EC=2.4.2.1
Alternative name(s):
Inosine phosphorylase
Inosine-guanosine phosphorylase
Gene names
Name:Pnp
Synonyms:Np
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate By similarity.

Catalytic activity

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. UniProtKB P00491

Pathway

Purine metabolism; purine nucleoside salvage.

Subunit structure

Homotrimer By similarity. UniProtKB P00491

Subcellular location

Cytoplasmcytoskeleton Ref.2.

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Purine nucleoside phosphorylase
PRO_0000349126

Amino acid modifications

Modified residue11N-acetylmethionine By similarity UniProtKB P00491

Sequences

Sequence LengthMass (Da)Tools
P85973 [UniParc].

Last modified September 2, 2008. Version 1.
Checksum: 004486E55848749B

FASTA28932,302
        10         20         30         40         50         60 
MENEFTYEDY QRTAEWLRSH TKHRPQVAVI CGSGLGGLTA KLTQPQAFDY NEIPNFPQST 

        70         80         90        100        110        120 
VQGHAGRLVF GFLNGRSCVM MQGRFHMYEG YSLSKVTFPV RVFHLLGVDT LVVTNAAGGL 

       130        140        150        160        170        180 
NPKFEVGDIM LIRDHINLPG FCGQNPLRGP NDERFGVRFP AMSDAYDRDM RQKAFNAWKQ 

       190        200        210        220        230        240 
MGEQRELQEG TYIMSAGPTF ETVAESCLLR MLGADAVGMS TVPEVIVARH CGLRVFGFSL 

       250        260        270        280 
ITNKVVMDYN NLEKASHQEV LEAGKAAAQK LEQFVSILME SIPPRERAN 

« Hide

References

« Hide 'large scale' references
[1]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Proteome profile of the mature rat olfactory bulb."
Maurya D.K., Sundaram C.S., Bhargava P.
Proteomics 9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH474040 Genomic DNA. Translation: EDL88431.1.
RefSeqXP_006251919.1. XM_006251857.1.
UniGeneRn.2738.

3D structure databases

ProteinModelPortalP85973.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL2395.

2D gel databases

World-2DPAGE0004:P85973.

Proteomic databases

PaxDbP85973.
PRIDEP85973.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID290029.
KEGGrno:290029.
UCSCRGD:1597189. rat.

Organism-specific databases

CTD4860.
RGD1597189. Pnp.

Phylogenomic databases

eggNOGCOG0005.
HOGENOMHOG000045183.
HOVERGENHBG002460.
KOK03783.
PhylomeDBP85973.
TreeFamTF300049.

Enzyme and pathway databases

UniPathwayUPA00606.

Gene expression databases

GenevestigatorP85973.

Family and domain databases

Gene3D3.40.50.1580. 1 hit.
InterProIPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
IPR011268. Purine_phosphorylase.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERPTHR11904. PTHR11904. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
PIRSFPIRSF000477. PurNPase. 1 hit.
SUPFAMSSF53167. SSF53167. 1 hit.
TIGRFAMsTIGR01700. PNPH. 1 hit.
TIGR01697. PNPH-PUNA-XAPA. 1 hit.
PROSITEPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePNPH_RAT
AccessionPrimary (citable) accession number: P85973
Secondary accession number(s): A6KEC5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 11, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways