SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P85973

- PNPH_RAT

UniProt

P85973 - PNPH_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Purine nucleoside phosphorylase

Gene
Pnp, Np
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate By similarity.

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.By similarity

Pathwayi

GO - Molecular functioni

  1. purine-nucleoside phosphorylase activity Source: RGD

GO - Biological processi

  1. purine-containing compound salvage Source: RGD
  2. purine nucleoside metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00606.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylase (EC:2.4.2.1)
Short name:
PNP
Alternative name(s):
Inosine phosphorylase
Inosine-guanosine phosphorylase
Gene namesi
Name:Pnp
Synonyms:Np
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1597189. Pnp.

Subcellular locationi

Cytoplasmcytoskeleton 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. cytoskeleton Source: UniProtKB-SubCell
  3. extracellular region Source: RGD
  4. nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Purine nucleoside phosphorylasePRO_0000349126Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarityBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP85973.
PRIDEiP85973.

2D gel databases

World-2DPAGE0004:P85973.

Expressioni

Gene expression databases

GenevestigatoriP85973.

Interactioni

Subunit structurei

Homotrimer By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliP85973.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0005.
HOGENOMiHOG000045183.
HOVERGENiHBG002460.
KOiK03783.
PhylomeDBiP85973.
TreeFamiTF300049.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
IPR011268. Purine_phosphorylase.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000477. PurNPase. 1 hit.
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01700. PNPH. 1 hit.
TIGR01697. PNPH-PUNA-XAPA. 1 hit.
PROSITEiPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P85973-1 [UniParc]FASTAAdd to Basket

« Hide

MENEFTYEDY QRTAEWLRSH TKHRPQVAVI CGSGLGGLTA KLTQPQAFDY    50
NEIPNFPQST VQGHAGRLVF GFLNGRSCVM MQGRFHMYEG YSLSKVTFPV 100
RVFHLLGVDT LVVTNAAGGL NPKFEVGDIM LIRDHINLPG FCGQNPLRGP 150
NDERFGVRFP AMSDAYDRDM RQKAFNAWKQ MGEQRELQEG TYIMSAGPTF 200
ETVAESCLLR MLGADAVGMS TVPEVIVARH CGLRVFGFSL ITNKVVMDYN 250
NLEKASHQEV LEAGKAAAQK LEQFVSILME SIPPRERAN 289
Length:289
Mass (Da):32,302
Last modified:September 2, 2008 - v1
Checksum:i004486E55848749B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH474040 Genomic DNA. Translation: EDL88431.1.
RefSeqiXP_006251919.1. XM_006251857.1.
UniGeneiRn.2738.

Genome annotation databases

GeneIDi290029.
KEGGirno:290029.
UCSCiRGD:1597189. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH474040 Genomic DNA. Translation: EDL88431.1 .
RefSeqi XP_006251919.1. XM_006251857.1.
UniGenei Rn.2738.

3D structure databases

ProteinModelPortali P85973.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2395.

2D gel databases

World-2DPAGE 0004:P85973.

Proteomic databases

PaxDbi P85973.
PRIDEi P85973.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 290029.
KEGGi rno:290029.
UCSCi RGD:1597189. rat.

Organism-specific databases

CTDi 4860.
RGDi 1597189. Pnp.

Phylogenomic databases

eggNOGi COG0005.
HOGENOMi HOG000045183.
HOVERGENi HBG002460.
KOi K03783.
PhylomeDBi P85973.
TreeFami TF300049.

Enzyme and pathway databases

UniPathwayi UPA00606 .

Gene expression databases

Genevestigatori P85973.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
InterProi IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR011270. Pur_Nuc_Pase_Ino/Guo-sp.
IPR011268. Purine_phosphorylase.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF000477. PurNPase. 1 hit.
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01700. PNPH. 1 hit.
TIGR01697. PNPH-PUNA-XAPA. 1 hit.
PROSITEi PS01240. PNP_MTAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Proteome profile of the mature rat olfactory bulb."
    Maurya D.K., Sundaram C.S., Bhargava P.
    Proteomics 9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPNPH_RAT
AccessioniPrimary (citable) accession number: P85973
Secondary accession number(s): A6KEC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 11, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi