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Protein

6-phosphogluconolactonase

Gene

Pgls

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.By similarity

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).By similarity
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (G6pdx)
  2. 6-phosphogluconolactonase (Pgls)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (Kif1b), 6-phosphogluconate dehydrogenase, decarboxylating (Pgd), 6-phosphogluconate dehydrogenase, decarboxylating (Pgd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

  • 6-phosphogluconolactonase activity Source: RGD
  • monosaccharide binding Source: RGD

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • pentose-phosphate shunt, oxidative branch Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseBy similarity (EC:3.1.1.31)
Short name:
6PGLBy similarity
Gene namesi
Name:PglsBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1307001. Pgls.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003491182 – 2576-phosphogluconolactonaseAdd BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei49PhosphoserineCombined sources1
Modified residuei180N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP85971.
PRIDEiP85971.

2D gel databases

World-2DPAGE0004:P85971.

PTM databases

iPTMnetiP85971.
PhosphoSitePlusiP85971.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018326.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024827.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3147. Eukaryota.
COG0363. LUCA.
HOGENOMiHOG000256285.
HOVERGENiHBG000030.
InParanoidiP85971.
PhylomeDBiP85971.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P85971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPAPGLIS VFSSPQELGA SLAQLVAQRA ASCLEGNRGR FALGLSGGSL
60 70 80 90 100
VSMLARDLPA ATAPAGPASF ARWTLGFCDE RLVPFDHAES TYGLYRTHLL
110 120 130 140 150
SKLPIPDSQV LTIDPALPVE DAAEDYARKL RQAFQGDTVP VFDLLILGVG
160 170 180 190 200
PDGHTCSLFP GHPLLQEREK IVAPIGDSPK PPPQRVTLTL PVLNAAQSVI
210 220 230 240 250
FVATGEGKAA VLKRILEDQE SALPAAMVQP RTGALCWFLD EAAARLLSVP

FEKHSTL
Length:257
Mass (Da):27,234
Last modified:September 2, 2008 - v1
Checksum:iDB98A38BFAFE54F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03100626 Genomic DNA. No translation available.
UniGeneiRn.19855.

Genome annotation databases

UCSCiRGD:1307001. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03100626 Genomic DNA. No translation available.
UniGeneiRn.19855.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024827.

PTM databases

iPTMnetiP85971.
PhosphoSitePlusiP85971.

2D gel databases

World-2DPAGE0004:P85971.

Proteomic databases

PaxDbiP85971.
PRIDEiP85971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:1307001. rat.

Organism-specific databases

RGDi1307001. Pgls.

Phylogenomic databases

eggNOGiKOG3147. Eukaryota.
COG0363. LUCA.
HOGENOMiHOG000256285.
HOVERGENiHBG000030.
InParanoidiP85971.
PhylomeDBiP85971.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.

Miscellaneous databases

PROiP85971.

Gene expression databases

BgeeiENSRNOG00000018326.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei6PGL_RAT
AccessioniPrimary (citable) accession number: P85971
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 2, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.