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P85971

- 6PGL_RAT

UniProt

P85971 - 6PGL_RAT

Protein

6-phosphogluconolactonase

Gene

Pgls

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

    Catalytic activityi

    6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.By similarity

    Pathwayi

    GO - Molecular functioni

    1. 6-phosphogluconolactonase activity Source: RGD
    2. monosaccharide binding Source: RGD

    GO - Biological processi

    1. pentose-phosphate shunt, oxidative branch Source: RGD

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_226758. Pentose phosphate pathway (hexose monophosphate shunt).
    UniPathwayiUPA00115; UER00409.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phosphogluconolactonaseBy similarity (EC:3.1.1.31)
    Short name:
    6PGLBy similarity
    Gene namesi
    Name:PglsBy similarity
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1307001. Pgls.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 2572566-phosphogluconolactonasePRO_0000349118Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei180 – 1801N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP85971.
    PRIDEiP85971.

    2D gel databases

    World-2DPAGE0004:P85971.

    PTM databases

    PhosphoSiteiP85971.

    Expressioni

    Gene expression databases

    GenevestigatoriP85971.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000024827.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0363.
    HOGENOMiHOG000256285.
    HOVERGENiHBG000030.
    PhylomeDBiP85971.

    Family and domain databases

    InterProiIPR005900. 6-phosphogluconolactonase_DevB.
    IPR006148. Glc/Gal-6P_isomerase.
    [Graphical view]
    PfamiPF01182. Glucosamine_iso. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01198. pgl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P85971-1 [UniParc]FASTAAdd to Basket

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    MAAPAPGLIS VFSSPQELGA SLAQLVAQRA ASCLEGNRGR FALGLSGGSL    50
    VSMLARDLPA ATAPAGPASF ARWTLGFCDE RLVPFDHAES TYGLYRTHLL 100
    SKLPIPDSQV LTIDPALPVE DAAEDYARKL RQAFQGDTVP VFDLLILGVG 150
    PDGHTCSLFP GHPLLQEREK IVAPIGDSPK PPPQRVTLTL PVLNAAQSVI 200
    FVATGEGKAA VLKRILEDQE SALPAAMVQP RTGALCWFLD EAAARLLSVP 250
    FEKHSTL 257
    Length:257
    Mass (Da):27,234
    Last modified:September 2, 2008 - v1
    Checksum:iDB98A38BFAFE54F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03100626 Genomic DNA. No translation available.
    UniGeneiRn.19855.

    Genome annotation databases

    UCSCiRGD:1307001. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03100626 Genomic DNA. No translation available.
    UniGenei Rn.19855.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000024827.

    PTM databases

    PhosphoSitei P85971.

    2D gel databases

    World-2DPAGE 0004:P85971.

    Proteomic databases

    PaxDbi P85971.
    PRIDEi P85971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:1307001. rat.

    Organism-specific databases

    RGDi 1307001. Pgls.

    Phylogenomic databases

    eggNOGi COG0363.
    HOGENOMi HOG000256285.
    HOVERGENi HBG000030.
    PhylomeDBi P85971.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00409 .
    Reactomei REACT_226758. Pentose phosphate pathway (hexose monophosphate shunt).

    Miscellaneous databases

    PROi P85971.

    Gene expression databases

    Genevestigatori P85971.

    Family and domain databases

    InterProi IPR005900. 6-phosphogluconolactonase_DevB.
    IPR006148. Glc/Gal-6P_isomerase.
    [Graphical view ]
    Pfami PF01182. Glucosamine_iso. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01198. pgl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway1 Publication.
    2. "Proteome profile of the mature rat olfactory bulb."
      Maurya D.K., Sundaram C.S., Bhargava P.
      Proteomics 9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry namei6PGL_RAT
    AccessioniPrimary (citable) accession number: P85971
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3