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Protein

Actin-related protein 2/3 complex subunit 2

Gene

Arpc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).By similarity

GO - Molecular functioni

  • AP-1 adaptor complex binding Source: MGI
  • Arp2/3 complex binding Source: MGI
  • kinesin binding Source: MGI

GO - Biological processi

  • Arp2/3 complex-mediated actin nucleation Source: InterPro
  • cellular response to hydrogen peroxide Source: RGD
  • cellular response to nerve growth factor stimulus Source: RGD
  • positive regulation of smooth muscle cell migration Source: RGD
  • response to silicon dioxide Source: RGD
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 2By similarity
Alternative name(s):
Arp2/3 complex 34 kDa subunitBy similarity
Short name:
p34-ARCBy similarity
Gene namesi
Name:Arpc2By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305848. Arpc2.

Subcellular locationi

GO - Cellular componenti

  • Arp2/3 protein complex Source: InterPro
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: UniProtKB-KW
  • growth cone Source: RGD
  • synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Actin-related protein 2/3 complex subunit 2PRO_0000349119Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei275 – 2751N6-acetyllysineBy similarity
Modified residuei295 – 2951N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP85970.
PRIDEiP85970.

2D gel databases

World-2DPAGE0004:P85970.

PTM databases

iPTMnetiP85970.

Expressioni

Gene expression databases

GenevisibleiP85970. RN.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex (By similarity).By similarity

GO - Molecular functioni

  • AP-1 adaptor complex binding Source: MGI
  • Arp2/3 complex binding Source: MGI
  • kinesin binding Source: MGI

Protein-protein interaction databases

IntActiP85970. 3 interactions.
MINTiMINT-8119010.
STRINGi10116.ENSRNOP00000019265.

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC2 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG2826. Eukaryota.
ENOG410YKF6. LUCA.
HOGENOMiHOG000212535.
HOVERGENiHBG050580.
InParanoidiP85970.
OMAiVFIQEFV.
OrthoDBiEOG73JKVS.
PhylomeDBiP85970.
TreeFamiTF315006.

Family and domain databases

InterProiIPR007188. ARPC2.
[Graphical view]
PANTHERiPTHR12058. PTHR12058. 1 hit.
PfamiPF04045. P34-Arc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P85970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG
60 70 80 90 100
DKTKVMVSIS LKFYKELQAH GADELLKRVY GSFLVNPESG YNVSLLYDLE
110 120 130 140 150
NLPASKDSIV HQAGMLKRNC FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE
160 170 180 190 200
TMYVESKKDR VTVVFSTVFK DDDDVVIGKV FMQEFKEGRR ASHTAPQVLF
210 220 230 240 250
SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNATARDNT INLIHTFRDY
260 270 280 290 300
LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITRKTFSST
Length:300
Mass (Da):34,391
Last modified:September 2, 2008 - v1
Checksum:i3E016531BA8E0982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03068131 Genomic DNA. No translation available.
AABR03068820 Genomic DNA. No translation available.
AABR03069184 Genomic DNA. No translation available.
UniGeneiRn.93317.

Genome annotation databases

UCSCiRGD:1305848. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03068131 Genomic DNA. No translation available.
AABR03068820 Genomic DNA. No translation available.
AABR03069184 Genomic DNA. No translation available.
UniGeneiRn.93317.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP85970. 3 interactions.
MINTiMINT-8119010.
STRINGi10116.ENSRNOP00000019265.

PTM databases

iPTMnetiP85970.

2D gel databases

World-2DPAGE0004:P85970.

Proteomic databases

PaxDbiP85970.
PRIDEiP85970.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:1305848. rat.

Organism-specific databases

RGDi1305848. Arpc2.

Phylogenomic databases

eggNOGiKOG2826. Eukaryota.
ENOG410YKF6. LUCA.
HOGENOMiHOG000212535.
HOVERGENiHBG050580.
InParanoidiP85970.
OMAiVFIQEFV.
OrthoDBiEOG73JKVS.
PhylomeDBiP85970.
TreeFamiTF315006.

Miscellaneous databases

PROiP85970.

Gene expression databases

GenevisibleiP85970. RN.

Family and domain databases

InterProiIPR007188. ARPC2.
[Graphical view]
PANTHERiPTHR12058. PTHR12058. 1 hit.
PfamiPF04045. P34-Arc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway1 Publication.
  2. "Proteome profile of the mature rat olfactory bulb."
    Maurya D.K., Sundaram C.S., Bhargava P.
    Proteomics 9:2593-2599(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiARPC2_RAT
AccessioniPrimary (citable) accession number: P85970
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 8, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.