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Protein

Actin-related protein 2/3 complex subunit 2

Gene

Arpc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).By similarity

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • AP-1 adaptor complex binding Source: MGI
  • Arp2/3 complex binding Source: MGI
  • ATPase binding Source: RGD
  • glutamate receptor binding Source: RGD
  • kinesin binding Source: MGI
  • protein complex binding Source: RGD
  • structural constituent of cytoskeleton Source: RGD

GO - Biological processi

  • actin filament polymerization Source: InterPro
  • Arp2/3 complex-mediated actin nucleation Source: RGD
  • cellular response to epidermal growth factor stimulus Source: RGD
  • cellular response to hydrogen peroxide Source: RGD
  • cellular response to nerve growth factor stimulus Source: RGD
  • cellular response to phorbol 13-acetate 12-myristate Source: RGD
  • cellular response to platelet-derived growth factor stimulus Source: RGD
  • cellular response to rapamycin Source: RGD
  • positive regulation of actin cytoskeleton reorganization Source: RGD
  • positive regulation of actin filament polymerization Source: RGD
  • positive regulation of barbed-end actin filament capping Source: RGD
  • positive regulation of filopodium assembly Source: RGD
  • positive regulation of invadopodium assembly Source: RGD
  • positive regulation of lamellipodium assembly Source: RGD
  • positive regulation of podosome assembly Source: RGD
  • positive regulation of protein targeting to membrane Source: RGD
  • positive regulation of smooth muscle cell migration Source: RGD
  • positive regulation of substrate adhesion-dependent cell spreading Source: RGD
  • response to silicon dioxide Source: RGD

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 2By similarity
Alternative name(s):
Arp2/3 complex 34 kDa subunitBy similarity
Short name:
p34-ARCBy similarity
Gene namesi
Name:Arpc2By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305848. Arpc2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003491191 – 300Actin-related protein 2/3 complex subunit 2Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei275N6-acetyllysineBy similarity1
Modified residuei295N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP85970.
PRIDEiP85970.

2D gel databases

World-2DPAGEi0004:P85970.

PTM databases

iPTMnetiP85970.
PhosphoSitePlusiP85970.

Expressioni

Gene expression databases

GenevisibleiP85970. RN.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex (By similarity).By similarity

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • AP-1 adaptor complex binding Source: MGI
  • Arp2/3 complex binding Source: MGI
  • ATPase binding Source: RGD
  • glutamate receptor binding Source: RGD
  • kinesin binding Source: MGI
  • protein complex binding Source: RGD

Protein-protein interaction databases

IntActiP85970. 3 interactors.
MINTiMINT-8119010.
STRINGi10116.ENSRNOP00000019265.

Structurei

3D structure databases

SMRiP85970.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARPC2 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG2826. Eukaryota.
ENOG410YKF6. LUCA.
HOGENOMiHOG000212535.
HOVERGENiHBG050580.
InParanoidiP85970.
OrthoDBiEOG091G0BUH.
PhylomeDBiP85970.
TreeFamiTF315006.

Family and domain databases

Gene3Di3.30.1460.20. 2 hits.
InterProiView protein in InterPro
IPR007188. ARPC2.
IPR034666. ARPC2/4.
PANTHERiPTHR12058. PTHR12058. 1 hit.
PfamiView protein in Pfam
PF04045. P34-Arc. 1 hit.
SUPFAMiSSF69645. SSF69645. 2 hits.

Sequencei

Sequence statusi: Complete.

P85970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG
60 70 80 90 100
DKTKVMVSIS LKFYKELQAH GADELLKRVY GSFLVNPESG YNVSLLYDLE
110 120 130 140 150
NLPASKDSIV HQAGMLKRNC FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE
160 170 180 190 200
TMYVESKKDR VTVVFSTVFK DDDDVVIGKV FMQEFKEGRR ASHTAPQVLF
210 220 230 240 250
SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNATARDNT INLIHTFRDY
260 270 280 290 300
LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITRKTFSST
Length:300
Mass (Da):34,391
Last modified:September 2, 2008 - v1
Checksum:i3E016531BA8E0982
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03068131 Genomic DNA. No translation available.
AABR03068820 Genomic DNA. No translation available.
AABR03069184 Genomic DNA. No translation available.
UniGeneiRn.93317.

Genome annotation databases

UCSCiRGD:1305848. rat.

Similar proteinsi

Entry informationi

Entry nameiARPC2_RAT
AccessioniPrimary (citable) accession number: P85970
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: November 22, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families