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Protein

Beta-soluble NSF attachment protein

Gene

Napb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.By similarity

GO - Molecular functioni

  • SNARE binding Source: UniProtKB
  • soluble NSF attachment protein activity Source: GO_Central
  • syntaxin binding Source: UniProtKB

GO - Biological processi

  • intracellular protein transport Source: GO_Central
  • membrane fusion Source: GO_Central
  • protein complex disassembly Source: UniProtKB
  • regulation of ATPase activity Source: UniProtKB
  • regulation of receptor internalization Source: UniProtKB
  • SNARE complex disassembly Source: GO_Central

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-soluble NSF attachment proteinBy similarity
Short name:
SNAP-betaBy similarity
Alternative name(s):
N-ethylmaleimide-sensitive factor attachment protein betaBy similarity
Gene namesi
Name:NapbBy similarity
Synonyms:SnapbBy similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1589649. Napb.

Subcellular locationi

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003491161 – 297Beta-soluble NSF attachment proteinAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP85969.
PRIDEiP85969.

2D gel databases

World-2DPAGEi0004:P85969.

PTM databases

iPTMnetiP85969.
PhosphoSitePlusiP85969.

Interactioni

Subunit structurei

Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2.By similarity

GO - Molecular functioni

  • SNARE binding Source: UniProtKB
  • soluble NSF attachment protein activity Source: GO_Central
  • syntaxin binding Source: UniProtKB

Protein-protein interaction databases

CORUMiP85969.
IntActiP85969. 1 interactor.
STRINGi10116.ENSRNOP00000006329.

Structurei

3D structure databases

ProteinModelPortaliP85969.
SMRiP85969.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAP family.Sequence analysis

Phylogenomic databases

eggNOGiKOG1586. Eukaryota.
ENOG410XPQ6. LUCA.
HOGENOMiHOG000165015.
HOVERGENiHBG001325.
InParanoidiP85969.
PhylomeDBiP85969.

Family and domain databases

CDDicd15832. SNAP. 1 hit.
Gene3Di1.25.40.10. 1 hit.
InterProiView protein in InterPro
IPR000744. NSF_attach.
IPR011990. TPR-like_helical_dom.
PANTHERiPTHR13768. PTHR13768. 1 hit.
PRINTSiPR00448. NSFATTACHMNT.
SUPFAMiSSF48452. SSF48452. 1 hit.

Sequencei

Sequence statusi: Complete.

P85969-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNAGKEREA VQLMAEAEKR VKASHSFLRG LFGGNTRIEE ACEMYTRAAN
60 70 80 90 100
MFKMAKNWSA AGNAFCQAAK LHMQLQSKHD SATSFVDAGN AYKKADPQEA
110 120 130 140 150
INCLNAAIDI YTDMGRFTIA AKHHITIAEI YETELVDIEK AIAHYEQSAD
160 170 180 190 200
YYKGEESNSA NKCLLKVAAY AAQLEQYQKA IEIYEQVGAN TMDNPLLKYS
210 220 230 240 250
AKDYFFKAAL CHFIVDELNA KLALEKYEEM FPAFTDSREC KLLKKLLEAH
260 270 280 290
EEQNSEAYTE AVKEFDSISR LDQWLTTMLL RIKKSIQGDG EGDGDLK
Length:297
Mass (Da):33,470
Last modified:September 2, 2008 - v1
Checksum:iF7F38BC930148315
GO

Sequence cautioni

The sequence EDL95093 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474026 Genomic DNA. Translation: EDL95093.1. Sequence problems.
UniGeneiRn.166492.

Genome annotation databases

UCSCiRGD:1589649. rat.

Similar proteinsi

Entry informationi

Entry nameiSNAB_RAT
AccessioniPrimary (citable) accession number: P85969
Secondary accession number(s): A6K7C6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: September 27, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families