P85841 (HUGA_TITSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Hyaluronidase Short name=Hya EC=3.2.1.35 Alternative name(s): Hyaluronoglucosaminidase
Organism	Tityus serrulatus (Brazilian scorpion)
Taxonomic identifier	6887 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Tityus

Protein attributes

Sequence length	34 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides By similarity.
Catalytic activity	Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
Subcellular location	Secreted Ref.1.
Tissue specificity	Expressed by the venom gland. Ref.1
Sequence similarities	Belongs to the glycosyl hydrolase 56 family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Glycosidase Hydrolase
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	hyalurononglucosaminidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›34	›34	Hyaluronidase		PRO_0000343459
Amino acid modifications
	Disulfide bond	13 ↔ ?		By similarity UniProtKB Q08169
Natural variations
	Natural variant	1	1	K → Q. Ref.1
Experimental info
	Non-terminal residue	34	1

Sequences

	Sequence		Length	Mass (Da)
	P85841 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 558FE619F243724B	FASTA	34	4,073
	10 20 30 KFKVYWEVPS FLCSKRFKIC VTEVLTSHEI LVNQ

References

[1]	"Hyaluronidase from venom of Brazilian scorpion Tityus serrulatus." Richardson M., Borges M.H., Cordeiro M.N., Pimenta A.M.C., de Lima M.E., Rates B. Submitted (MAY-2008) to UniProtKB Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT GLN-1. Tissue: Venom.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

HUGA_TITSE

Accession

Primary (citable) accession number: P85841

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	October 31, 2012
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)