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Protein

Ferritin, heavy subunit

Gene
N/A
Organism
Pseudotrematomus bernacchii (Emerald rockcod) (Trematomus bernacchii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi24Iron 1PROSITE-ProRule annotationBy similarity1
Metal bindingi59Iron 1PROSITE-ProRule annotationBy similarity1
Metal bindingi59Iron 2PROSITE-ProRule annotationBy similarity1
Metal bindingi62Iron 1PROSITE-ProRule annotationBy similarity1
Metal bindingi104Iron 2PROSITE-ProRule annotationBy similarity1
Metal bindingi138Iron 2PROSITE-ProRule annotationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin, heavy subunit1 Publication (EC:1.16.3.1)
Short name:
Ferritin H1 Publication
OrganismiPseudotrematomus bernacchii (Emerald rockcod) (Trematomus bernacchii)
Taxonomic identifieri40690 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesNotothenioideiNototheniidaeTrematomus

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003527801 – 174Ferritin, heavy subunitAdd BLAST174

Proteomic databases

PRIDEiP85838.

Expressioni

Tissue specificityi

Liver (at protein level).1 Publication

Interactioni

Subunit structurei

In liver, forms a heteropolymer consisting of middle and heavy subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.Curated1 Publication

Structurei

3D structure databases

SMRiP85838.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 156Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.Sequence analysis

Phylogenomic databases

HOVERGENiHBG000410.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiView protein in InterPro
IPR001519. Ferritin.
IPR012347. Ferritin-like.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiView protein in Pfam
PF00210. Ferritin. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiView protein in PROSITE
PS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

P85838-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESQVRQNFH KDCEAAINRQ INLELYASYS YLSMAYYFDR DDVALPGFAH
60 70 80 90 100
FFKQQSEEER EHAEKLLKFQ NQRGGRIFLQ DVKKPDRDEW GSGLDALECA
110 120 130 140 150
LQLEKNVNQS LLDLHKVCSE HNDPHMCDFL ETHYLDEQVK SIKELGDWVT
160 170
NLRRLGAPQN GMAEYLFDKH TLGK
Length:174
Mass (Da):20,371
Last modified:October 14, 2008 - v1
Checksum:i1BC8AFC0C7AB7512
GO

Similar proteinsi

Entry informationi

Entry nameiFRIH_PSEBE
AccessioniPrimary (citable) accession number: P85838
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 14, 2008
Last modified: November 22, 2017
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families