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P85836

- FRIML_TREBE

UniProt

P85836 - FRIML_TREBE

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Protein

Ferritin, liver middle subunit

Gene
N/A
Organism
Trematomus bernacchii (Emerald rockcod) (Pagothenia bernacchii)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi24 – 241Iron 1By similarityPROSITE-ProRule annotation
Metal bindingi59 – 591Iron 1By similarityPROSITE-ProRule annotation
Metal bindingi59 – 591Iron 2By similarityPROSITE-ProRule annotation
Metal bindingi62 – 621Iron 1By similarityPROSITE-ProRule annotation
Metal bindingi104 – 1041Iron 2By similarityPROSITE-ProRule annotation
Metal bindingi138 – 1381Iron 2By similarityPROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin, liver middle subunit1 Publication (EC:1.16.3.1)
Short name:
Ferritin M1 Publication
OrganismiTrematomus bernacchii (Emerald rockcod) (Pagothenia bernacchii)
Taxonomic identifieri40690 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesNotothenioideiNototheniidaeTrematomus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 176176Ferritin, liver middle subunitPRO_0000352782Add
BLAST

Proteomic databases

PRIDEiP85836.

Expressioni

Tissue specificityi

Liver (at protein level).1 Publication

Interactioni

Subunit structurei

In liver, forms a heteropolymer consisting of middle and heavy subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.1 PublicationCurated

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 156150Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family.Sequence Analysis
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG000410.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P85836-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSQVRQNYH RDCEAAVNRM INMELFASYS YTSMAFYFSR DDVALPGFAH
60 70 80 90 100
FFKENSDEER EHADKLLTFQ NSRGGRIFLQ DIKKPERDEW GSGLDALQSS
110 120 130 140 150
LQLEKNVNQA LLDLHKIASD HTDPHMCDFL ETHYLNEQVE SIKKLGDFIT
160 170
NLSRMDAVKN KMAEYLFDKH TMGGKN
Length:176
Mass (Da):20,436
Last modified:October 14, 2008 - v1
Checksum:iA61829EF2564AC4B
GO

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P85836.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000410.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The unusual co-assembly of H- and M-chains in the ferritin molecule from the Antarctic teleosts Trematomus bernacchii and Trematomus newnesi."
    Giorgi A., Mignogna G., Bellapadrona G., Gattoni M., Chiaraluce R., Consalvi V., Chiancone E., Stefanini S.
    Arch. Biochem. Biophys. 478:69-74(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, SUBUNIT, TISSUE SPECIFICITY.
    Tissue: Liver1 Publication.

Entry informationi

Entry nameiFRIML_TREBE
AccessioniPrimary (citable) accession number: P85836
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 14, 2008
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3