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Protein

Triosephosphate isomerase

Gene
N/A
Organism
Platanus orientalis (Oriental plane-tree)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.PROSITE-ProRule annotationBy similarity

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.PROSITE-ProRule annotationBy similarity
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.PROSITE-ProRule annotationBy similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei62Proton acceptorPROSITE-ProRule annotationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomerase (EC:5.3.1.1)
Short name:
TIM
Alternative name(s):
Triose-phosphate isomerase
Allergen: Pla o 4
OrganismiPlatanus orientalis (Oriental plane-tree)
Taxonomic identifieri122832 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsProtealesPlatanaceaePlatanus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000343452‹1 – ›86Triosephosphate isomeraseAdd BLAST›86

Proteomic databases

PRIDEiP85814

Interactioni

Subunit structurei

Homodimer.PROSITE-ProRule annotationBy similarity

Structurei

3D structure databases

ProteinModelPortaliP85814
SMRiP85814
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.20.20.70, 2 hits
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR000652 Triosephosphate_isomerase
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 2 hits
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Fragments.

P85814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATSLTAPP SFSGLRASRA VVAMAGTGKG GAFTGEISVE QLKDIGRWVI
60 70 80
LGHSERIVVA YEPVWAIGTG KVATPDQAQE VHGLCR
Length:86
Mass (Da):8,935
Last modified:July 1, 2008 - v1
Checksum:iD816B8C38C23ACA1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11 Publication1
Non-adjacent residuesi16 – 171 Publication2
Non-adjacent residuesi29 – 301 Publication2
Non-adjacent residuesi47 – 481 Publication2
Non-adjacent residuesi56 – 571 Publication2
Non-terminal residuei861 Publication1

Mass spectrometryi

Molecular mass is 27074.8 Da . Determined by MALDI. 1 Publication

Entry informationi

Entry nameiTPIS_PLAOI
AccessioniPrimary (citable) accession number: P85814
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: April 25, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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