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Protein

Triosephosphate isomerase

Gene
N/A
Organism
Platanus orientalis (Oriental plane tree)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.PROSITE-ProRule annotationBy similarity

Pathway:igluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.PROSITE-ProRule annotationBy similarity
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathway:iglycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.PROSITE-ProRule annotationBy similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Proton acceptorPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis, Pentose shunt

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomerase (EC:5.3.1.1)
Short name:
TIM
Alternative name(s):
Triose-phosphate isomerase
Allergen: Pla o 4
OrganismiPlatanus orientalis (Oriental plane tree)
Taxonomic identifieri122832 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsProtealesPlatanaceaePlatanus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›86›86Triosephosphate isomerasePRO_0000343452Add
BLAST

Proteomic databases

PRIDEiP85814.

Interactioni

Subunit structurei

Homodimer.PROSITE-ProRule annotationBy similarity

Structurei

3D structure databases

ProteinModelPortaliP85814.
SMRiP85814. Positions 54-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 2 hits.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragments.

P85814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATSLTAPP SFSGLRASRA VVAMAGTGKG GAFTGEISVE QLKDIGRWVI
60 70 80
LGHSERIVVA YEPVWAIGTG KVATPDQAQE VHGLCR
Length:86
Mass (Da):8,935
Last modified:July 1, 2008 - v1
Checksum:iD816B8C38C23ACA1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 111 Publication
Non-adjacent residuesi16 – 1721 Publication
Non-adjacent residuesi29 – 3021 Publication
Non-adjacent residuesi47 – 4821 Publication
Non-adjacent residuesi56 – 5721 Publication
Non-terminal residuei86 – 8611 Publication

Mass spectrometryi

Molecular mass is 27074.8 Da . Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

ProteinModelPortaliP85814.
SMRiP85814. Positions 54-86.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP85814.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189.
UPA00138.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiIPR013785. Aldolase_TIM.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF00121. TIM. 2 hits.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
PROSITEiPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification, cloning and expression of Platanus orientalis pollen allergens."
    Pazouki N.
    Thesis (2008), Islamic Azad university, Iran
    Cited for: PROTEIN SEQUENCE, MASS SPECTROMETRY, ALLERGEN.
    Tissue: Pollen1 Publication.

Entry informationi

Entry nameiTPIS_PLAOI
AccessioniPrimary (citable) accession number: P85814
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 26, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.