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Protein

Alpha-centractin

Gene

Actr1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • spermatogenesis Source: RGD

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-2132295. MHC class II antigen presentation.
R-RNO-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-RNO-3371497. HSP90 chaperone cycle for steroid hormone receptors (SHR).
R-RNO-380259. Loss of Nlp from mitotic centrosomes.
R-RNO-380270. Recruitment of mitotic centrosome proteins and complexes.
R-RNO-380320. Recruitment of NuMA to mitotic centrosomes.
R-RNO-5620912. Anchoring of the basal body to the plasma membrane.
R-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-RNO-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-centractin
Short name:
Centractin
Gene namesi
Name:Actr1aBy similarity
Synonyms:Ctrn1By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1307025. Actr1a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003289401 – 376Alpha-centractinAdd BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP85515.
PRIDEiP85515.

2D gel databases

World-2DPAGEi0004:P85515.

PTM databases

iPTMnetiP85515.
PhosphoSitePlusiP85515.

Expressioni

Gene expression databases

BgeeiENSRNOG00000019725.
GenevisibleiP85515. RN.

Interactioni

Subunit structurei

Interacts with BCCIP.By similarity

Protein-protein interaction databases

BioGridi254541. 1 interactor.
IntActiP85515. 2 interactors.
STRINGi10116.ENSRNOP00000026792.

Structurei

3D structure databases

ProteinModelPortaliP85515.
SMRiP85515.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP1 subfamily.Sequence analysis

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00900000140893.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiP85515.
KOiK16575.
OMAiKIKYPME.
OrthoDBiEOG091G08LD.
PhylomeDBiP85515.
TreeFamiTF300420.

Family and domain databases

InterProiView protein in InterPro
IPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR029909. Arp1.
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF195. PTHR11937:SF195. 1 hit.
PfamiView protein in Pfam
PF00022. Actin. 1 hit.
PRINTSiPR00190. ACTIN.
SMARTiView protein in SMART
SM00268. ACTIN. 1 hit.
PROSITEiView protein in PROSITE
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

P85515-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESYDVIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHVRVMAG
60 70 80 90 100
ALEGDIFIGP KAEEHRGLLS IRYPMEHGIV KDWNDMERIW QYVYSKDQLQ
110 120 130 140 150
TFSEEHPVLL TEAPLNPRKN RERAAEVFFE TFNVPALFIS MQAVLSLYAT
160 170 180 190 200
GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI MRIDIAGRDV SRFLRLYLRK
210 220 230 240 250
EGYDFHSSSE FEIVKAIKER ACYLSINPQK DETLETEKAQ YYLPDGSTIE
260 270 280 290 300
IGPSRFRAPE LLFRPDLIGE ESEGIHEVLV FAIQKSDMDL RRTLFSNIVL
310 320 330 340 350
SGGSTLFKGF GDRLLSEVKK LAPKDVKIRI SAPQERLYST WIGGSILASL
360 370
DTFKKMWVSK KEYEEDGARS IHRKTF
Length:376
Mass (Da):42,614
Last modified:April 8, 2008 - v1
Checksum:i4A978E7AB3739436
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096363 Genomic DNA. No translation available.
RefSeqiNP_001099834.1. NM_001106364.1.
UniGeneiRn.32312.

Genome annotation databases

EnsembliENSRNOT00000026792; ENSRNOP00000026792; ENSRNOG00000019725.
GeneIDi294010.
KEGGirno:294010.
UCSCiRGD:1307025. rat.

Similar proteinsi

Entry informationi

Entry nameiACTZ_RAT
AccessioniPrimary (citable) accession number: P85515
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 22, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families