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P85299

- PRR5_HUMAN

UniProt

P85299 - PRR5_HUMAN

Protein

Proline-rich protein 5

Gene

PRR5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (23 Oct 2007)
      Previous versions | rss
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    Functioni

    Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer.2 Publications

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    3. positive regulation of protein phosphorylation Source: Ensembl

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proline-rich protein 5
    Alternative name(s):
    Protein observed with Rictor-1
    Short name:
    Protor-1
    Gene namesi
    Name:PRR5
    Synonyms:PROTOR1
    ORF Names:PP610
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:31682. PRR5.

    Subcellular locationi

    GO - Cellular componenti

    1. TORC2 complex Source: UniProtKB

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA144596392.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388Proline-rich protein 5PRO_0000308162Add
    BLAST

    Proteomic databases

    MaxQBiP85299.
    PaxDbiP85299.
    PRIDEiP85299.

    PTM databases

    PhosphoSiteiP85299.

    Expressioni

    Tissue specificityi

    Most abundant in kidney and liver. Also highly expressed in brain, spleen, testis and placenta. Overexpressed in several colorectal tumors.2 Publications

    Gene expression databases

    ArrayExpressiP85299.
    BgeeiP85299.
    GenevestigatoriP85299.

    Organism-specific databases

    HPAiHPA054072.

    Interactioni

    Subunit structurei

    Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and RICTOR within the TORC2 complex.2 Publications

    Protein-protein interaction databases

    BioGridi120755. 6 interactions.
    IntActiP85299. 13 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP85299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni10 – 9586Interaction with RICTORAdd
    BLAST
    Regioni188 – 21831Interaction with RICTORAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi24 – 274Poly-Ala

    Sequence similaritiesi

    Belongs to the PROTOR family.Curated

    Phylogenomic databases

    eggNOGiNOG46045.
    HOVERGENiHBG067971.
    OMAiSCILEKH.
    PhylomeDBiP85299.
    TreeFamiTF314826.

    Family and domain databases

    InterProiIPR016159. Cullin_repeat-like_dom.
    IPR013745. HbrB.
    [Graphical view]
    PfamiPF08539. HbrB. 1 hit.
    [Graphical view]
    SUPFAMiSSF74788. SSF74788. 1 hit.

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P85299-1) [UniParc]FASTAAdd to Basket

    Also known as: alpha

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRTLRRLKFM SSPSLSDLGK REPAAAADER GTQQRRACAN ATWNSIHNGV    50
    IAVFQRKGLP DQELFSLNEG VRQLLKTELG SFFTEYLQNQ LLTKGMVILR 100
    DKIRFYEGQK LLDSLAETWD FFFSDVLPML QAIFYPVQGK EPSVRQLALL 150
    HFRNAITLSV KLEDALARAH ARVPPAIVQM LLVLQGVHES RGVTEDYLRL 200
    ETLVQKVVSP YLGTYGLHSS EGPFTHSCIL EKRLLRRSRS GDVLAKNPVV 250
    RSKSYNTPLL NPVQEHEAEG AAAGGTSIRR HSVSEMTSCP EPQGFSDPPG 300
    QGPTGTFRSS PAPHSGPCPS RLYPTTQPPE QGLDPTRSSL PRSSPENLVD 350
    QILESVDSDS EGIFIDFGRG RGSGMSDLEG SGGRQSVV 388
    Length:388
    Mass (Da):42,753
    Last modified:October 23, 2007 - v1
    Checksum:iFA6B90495623EF3F
    GO
    Isoform 2 (identifier: P85299-2) [UniParc] [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-101: Missing.
         102-107: KIRFYE → MAPMPT

    Show »
    Length:287
    Mass (Da):31,125
    Checksum:i24E46CD123CA100E
    GO
    Isoform 3 (identifier: P85299-3) [UniParc]FASTAAdd to Basket

    Also known as: beta

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: Missing.

    Note: Derived from EST data. No experimental confirmation available.

    Show »
    Length:379
    Mass (Da):41,551
    Checksum:i1A0E3E17802AFD85
    GO
    Isoform 4 (identifier: P85299-4) [UniParc]FASTAAdd to Basket

    Also known as: gamma

    The sequence of this isoform differs from the canonical sequence as follows:
         1-95: Missing.

    Note: Derived from EST data. No experimental confirmation available.

    Show »
    Length:293
    Mass (Da):32,061
    Checksum:i63D42183C35C9A0B
    GO
    Isoform 5 (identifier: P85299-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-5: MRTLR → MVCLELSQREAWGSGSPEKMPAQPEGLY

    Note: No experimental confirmation available.

    Show »
    Length:411
    Mass (Da):45,172
    Checksum:i85B5B9159AB9350B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti280 – 2801R → W in BAA90999. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti243 – 2431V → M.
    Corresponds to variant rs36082900 [ dbSNP | Ensembl ].
    VAR_062230

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 101101Missing in isoform 2. 2 PublicationsVSP_001646Add
    BLAST
    Alternative sequencei1 – 9595Missing in isoform 4. CuratedVSP_028884Add
    BLAST
    Alternative sequencei1 – 99Missing in isoform 3. CuratedVSP_028885
    Alternative sequencei1 – 55MRTLR → MVCLELSQREAWGSGSPEKM PAQPEGLY in isoform 5. 1 PublicationVSP_045883
    Alternative sequencei102 – 1076KIRFYE → MAPMPT in isoform 2. 2 PublicationsVSP_001648

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000192 mRNA. Translation: BAA90999.1.
    AK055848 mRNA. Translation: BAG51585.1.
    AF177331 mRNA. Translation: AAG17975.1.
    Z93244, Z98743 Genomic DNA. Translation: CAQ06711.1.
    Z93244, Z98743 Genomic DNA. Translation: CAQ06720.1.
    Z98743, Z93244 Genomic DNA. Translation: CAQ09256.1.
    Z98743, Z93244 Genomic DNA. Translation: CAQ09263.1.
    CH471138 Genomic DNA. Translation: EAW73353.1.
    CH471138 Genomic DNA. Translation: EAW73355.1.
    BC016921 mRNA. Translation: AAH16921.1.
    BK005635 mRNA. Translation: DAA05654.1.
    BK005636 mRNA. Translation: DAA05655.1.
    BK005637 mRNA. Translation: DAA05656.1.
    BK005638 mRNA. Translation: DAA05657.1.
    BK005639 mRNA. Translation: DAA05658.1.
    CCDSiCCDS14058.1.
    CCDS14059.1. [P85299-3]
    CCDS56232.1. [P85299-5]
    RefSeqiNP_001017528.1. NM_001017528.2. [P85299-3]
    NP_001017529.1. NM_001017529.2. [P85299-4]
    NP_001017530.1. NM_001017530.1. [P85299-4]
    NP_001185650.1. NM_001198721.1. [P85299-5]
    NP_056181.2. NM_015366.3. [P85299-3]
    NP_851850.1. NM_181333.3. [P85299-1]
    UniGeneiHs.102336.

    Genome annotation databases

    EnsembliENST00000006251; ENSP00000006251; ENSG00000186654. [P85299-3]
    ENST00000336985; ENSP00000337464; ENSG00000186654. [P85299-1]
    ENST00000403581; ENSP00000384848; ENSG00000186654. [P85299-5]
    GeneIDi55615.
    KEGGihsa:55615.
    UCSCiuc003bew.2. human.
    uc003bfh.1. human. [P85299-2]
    uc010gzt.1. human.

    Polymorphism databases

    DMDMi160016058.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000192 mRNA. Translation: BAA90999.1 .
    AK055848 mRNA. Translation: BAG51585.1 .
    AF177331 mRNA. Translation: AAG17975.1 .
    Z93244 , Z98743 Genomic DNA. Translation: CAQ06711.1 .
    Z93244 , Z98743 Genomic DNA. Translation: CAQ06720.1 .
    Z98743 , Z93244 Genomic DNA. Translation: CAQ09256.1 .
    Z98743 , Z93244 Genomic DNA. Translation: CAQ09263.1 .
    CH471138 Genomic DNA. Translation: EAW73353.1 .
    CH471138 Genomic DNA. Translation: EAW73355.1 .
    BC016921 mRNA. Translation: AAH16921.1 .
    BK005635 mRNA. Translation: DAA05654.1 .
    BK005636 mRNA. Translation: DAA05655.1 .
    BK005637 mRNA. Translation: DAA05656.1 .
    BK005638 mRNA. Translation: DAA05657.1 .
    BK005639 mRNA. Translation: DAA05658.1 .
    CCDSi CCDS14058.1.
    CCDS14059.1. [P85299-3 ]
    CCDS56232.1. [P85299-5 ]
    RefSeqi NP_001017528.1. NM_001017528.2. [P85299-3 ]
    NP_001017529.1. NM_001017529.2. [P85299-4 ]
    NP_001017530.1. NM_001017530.1. [P85299-4 ]
    NP_001185650.1. NM_001198721.1. [P85299-5 ]
    NP_056181.2. NM_015366.3. [P85299-3 ]
    NP_851850.1. NM_181333.3. [P85299-1 ]
    UniGenei Hs.102336.

    3D structure databases

    ProteinModelPortali P85299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120755. 6 interactions.
    IntActi P85299. 13 interactions.

    PTM databases

    PhosphoSitei P85299.

    Polymorphism databases

    DMDMi 160016058.

    Proteomic databases

    MaxQBi P85299.
    PaxDbi P85299.
    PRIDEi P85299.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000006251 ; ENSP00000006251 ; ENSG00000186654 . [P85299-3 ]
    ENST00000336985 ; ENSP00000337464 ; ENSG00000186654 . [P85299-1 ]
    ENST00000403581 ; ENSP00000384848 ; ENSG00000186654 . [P85299-5 ]
    GeneIDi 55615.
    KEGGi hsa:55615.
    UCSCi uc003bew.2. human.
    uc003bfh.1. human. [P85299-2 ]
    uc010gzt.1. human.

    Organism-specific databases

    CTDi 55615.
    GeneCardsi GC22P045064.
    HGNCi HGNC:31682. PRR5.
    HPAi HPA054072.
    MIMi 609406. gene.
    neXtProti NX_P85299.
    PharmGKBi PA144596392.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46045.
    HOVERGENi HBG067971.
    OMAi SCILEKH.
    PhylomeDBi P85299.
    TreeFami TF314826.

    Miscellaneous databases

    ChiTaRSi PRR5. human.
    GenomeRNAii 55615.
    NextBioi 60196.
    PROi P85299.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P85299.
    Bgeei P85299.
    Genevestigatori P85299.

    Family and domain databases

    InterProi IPR016159. Cullin_repeat-like_dom.
    IPR013745. HbrB.
    [Graphical view ]
    Pfami PF08539. HbrB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF74788. SSF74788. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
      Tissue: Colon mucosa and Kidney.
    2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Liver.
    6. "PRR5 encodes a conserved proline-rich protein predominant in kidney: analysis of genomic organization, expression, and mutation status in breast and colorectal carcinomas."
      Johnstone C.N., Castellvi-Bel S., Chang L.M., Sung R.K., Bowser M.J., Pique J.M., Castells A., Rustgi A.K.
      Genomics 85:338-351(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION (ISOFORMS 1; 3 AND 4), FUNCTION, TISSUE SPECIFICITY.
    7. Cited for: IDENTIFICATION IN THE TORC2 COMPLEX, INTERACTION WITH RICTOR.
    8. "PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling."
      Woo S.-Y., Kim D.-H., Jun C.-B., Kim Y.-M., Haar E.V., Lee S.-I., Hegg J.W., Bandhakavi S., Griffin T.J., Kim D.-H.
      J. Biol. Chem. 282:25604-25612(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE TORC2 COMPLEX, INTERACTION WITH MTOR AND RICTOR, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPRR5_HUMAN
    AccessioniPrimary (citable) accession number: P85299
    Secondary accession number(s): B1AHF6
    , B1AHG5, B3KP73, O75983, O95695, Q5BIW2, Q5EAJ8, Q5EAJ9, Q5XKJ6, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NSG0, Q9NVX8, Q9NXL1, Q9UH20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3