Reviewed, UniProtKB/Swiss-Prot P85292 (NDKB_MACMG)

Names and origin

Protein names

Recommended name:
    Nucleoside diphosphate kinase B
      Short name=NDP kinase B
      Short name=NDK B
    EC=2.7.4.6

Gene names

Name:

nme2

Organism

Macruronus magellanicus (Patagonian grenadier) (Macruronus novaezelandiae magellanicus)

Taxonomic identifier

92050 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Paracanthopterygii › Gadiformes › Merlucciidae › Merlucciinae › Macruronus

Protein attributes

Sequence length	126 AA.
Sequence status	Fragments.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Major role in the synthesis of nucleoside triphosphates other than ATP By similarity. UniProtKB P15531
Catalytic activity	ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. UniProtKB P15531
Cofactor	Magnesium By similarity. UniProtKB P15531
Subcellular location	Cytoplasm By similarity. UniProtKB P15531
Sequence similarities	Belongs to the NDK family.

Ontologies

Keywords
Biological process	Cell cycle Nucleotide metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	CTP biosynthetic process Inferred from electronic annotation. Source: InterPro GTP biosynthetic process Inferred from electronic annotation. Source: InterPro UTP biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside diphosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 126	›126	Nucleoside diphosphate kinase B		PRO_0000306182
Sites
	Active site	92	1	Pros-phosphohistidine intermediate By similarity UniProtKB P15531
	Binding site	6	1	ATP By similarity UniProtKB P15531
	Binding site	37	1	ATP By similarity UniProtKB P15531
	Binding site	68	1	ATP By similarity UniProtKB P15531
	Binding site	79	1	ATP By similarity UniProtKB P15531
	Binding site	89	1	ATP By similarity UniProtKB P15531
Experimental info
	Non-adjacent residues	20 – 21	2
	Non-adjacent residues	24 – 25	2
	Non-adjacent residues	62 – 63	2
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P85292-1 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: C836BD599663F83A	FASTA	126	14,118
	10 20 30 40 50 60 TFIAIKPDGV QRGLCGEVMK FIQPMKQHYL DLKDMPFYAG LCKYMASGPV FAMVWEGEGI 70 80 90 100 110 120 VKMMLGETNP ADSKPGSIRG DFCINIGRNI IHGSDTLENA KMEIGLWFKG EEFVAYAEKA KAWVYE

References

[1]

"De novo mass spectrometry sequencing and characterization of species-specific peptides from nucleoside diphosphate kinase B for the classification of commercial fish species belonging to the family Merlucciidae." Carrera M., Canas B., Pineiro C., Vazquez J., Gallardo J.M. J. Proteome Res. 6:3070-3080(2007) [PubMed: 17622168] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: White muscle.

Cross-references

3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.4.6. 303344.
Family and domain databases
InterPro	IPR001564. Nuc_diP_kinase_core. [Graphical view]
Gene3D	G3DSA:3.30.70.141. NDK. 1 hit.
PANTHER	PTHR11349. Nuc_diP_kinase_core. 1 hit.
Pfam	PF00334. NDK. 1 hit. [Graphical view]
PRINTS	PR01243. NUCDPKINASE.
ProDom	PD001018. NDK. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00562. NDK. 1 hit. [Graphical view]
PROSITE	PS00469. NDP_KINASES. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDKB_MACMG

Accession

Primary (citable) accession number: P85292

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	October 13, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)