P85261 (KIWEL_ACTCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Kiwellin Alternative name(s): Allergen=Act c 5 Cleaved into the following 4 chains: Kissper KiTH-3 KiTH-1 KiTH-2
Organism	Actinidia chinensis (Kiwi) (Yangtao)
Taxonomic identifier	3625 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › Ericales › Actinidiaceae › Actinidia

Protein attributes

Sequence length	34 AA.
Sequence status	Fragments.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Kissper is an anion-selective pore-forming peptide By similarity. UniProtKB P84527
Subcellular location	Secreted By similarity UniProtKB P84527.
Post-translational modification	Undergoes proteolytic cleavage by actinidin to produce kissper and KiTH. Three forms of KiTH are produced by cleavage at different sites. Ref.1
Allergenic properties	Causes an allergic reaction in human. Binds to IgE from the serum of kiwi-allergic patients. Ref.1
Sequence similarities	Belongs to the kiwellin family.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›34	›34	Kiwellin		PRO_0000343453
	Peptide	1 – ?		Kissper Ref.1 UniProtKB P84527		PRO_0000343454
	Chain	21 – ›34	›14	KiTH-3 Ref.1		PRO_0000343455
	Chain	23 – ›34	›12	KiTH-1 Ref.1		PRO_0000343456
	Chain	25 – ›34	›10	KiTH-2 Ref.1		PRO_0000343457
Experimental info
	Non-adjacent residues	20 – 21	2
	Non-terminal residue	34	1

Sequences

	Sequence		Length	Mass (Da)
	P85261 [UniParc]. Last modified July 1, 2008. Version 1. Checksum: 79F2CF6B6C45670C	FASTA	34	3,502
	10 20 30 ISSCNGPCRD LNDCDGQLIC GTTHSHQPGG CKPS

References

[1]

"Kiwellin, a modular protein from green and gold kiwi fruits: evidence of in vivo and in vitro processing and IgE binding." Tuppo L., Giangrieco I., Palazzo P., Bernardi M.L., Scala E., Carratore V., Tamburrini M., Mari A., Ciardiello M.A. J. Agric. Food Chem. 56:3812-3817(2008) [PubMed: 18442249] [Abstract] Cited for: PROTEIN SEQUENCE, ALLERGEN, PROTEOLYTIC CLEAVAGE BY ACTINIDIN. Strain: cv. Hort 16A. Tissue: Fruit.

Cross-references

3D structure databases
ProteinModelPortal	P85261.
ModBase	Search...
Protein family/group databases
Allergome	4062. Act c 5. 5734. Act c 5.0101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

KIWEL_ACTCH

Accession

Primary (citable) accession number: P85261

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 2008
Last sequence update:	July 1, 2008
Last modified:	June 28, 2011
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program