Reviewed, UniProtKB/Swiss-Prot P85217 (METC_CRYLA)

Names and origin

Protein names	Recommended name:     Cystathionine beta lyase     EC=4.4.1.8
Organism	Cryptococcus laurentii
Taxonomic identifier	5418 [NCBI]
Taxonomic lineage	Eukaryota › Fungi › Dikarya › Basidiomycota › Agaricomycotina › Tremellomycetes › Tremellales › mitosporic Tremellales › Cryptococcus

Protein attributes

Sequence length	17 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate. UniProtKB A0RIN4
Cofactor	Pyridoxal phosphate By similarity. UniProtKB A0RIN4
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homocysteine from L-cystathionine: step 1/1.
Subcellular location	Cytoplasm By similarity. UniProtKB A0RIN4
Sequence similarities	Belongs to the trans-sulfuration enzymes family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Methionine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cystathionine beta-lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›17	›17	Cystathionine beta lyase		PRO_0000298774
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	17	1

Sequences

	Sequence		Length	Mass (Da)
	P85217-1 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 16A24179667D5E7A	FASTA	17	1,864
	10 HDVYGGDYRI TGDDGHS

References

[1]	"Functional nitrogenase in Cryptococcus laurentii strain RY1." Dutta D., Gachhui R. Submitted (JUL-2007) to UniProtKB Cited for: PROTEIN SEQUENCE. Strain: RY1.

Cross-references

3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.4.1.8. 2764.
Family and domain databases
InterPro	IPR000277. Cys/Met-Metab_PyrdxlP-dep_enz. [Graphical view]
PROSITE	PS00868. CYS_MET_METAB_PP. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

METC_CRYLA

Accession

Primary (citable) accession number: P85217

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	June 16, 2009
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)