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P85064

- SPI_SCHGR

UniProt

P85064 - SPI_SCHGR

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Protein

Greglin

Gene
N/A
Organism
Schistocerca gregaria (Desert locust)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Serine protease inhibitor. Inhibits porcine pancreatic elastase with a Ki of 58.3 nM, human neutrophil elastase with a Ki of 3.6 nM, cathepsin G with a Ki of 153.5 nM, chymotrypsin with a Ki of 26.7 nM and subtilisin with a Ki of 0.68 nM. Does not inhibit neutrophil protease 3 or pancreatic trypsin.1 Publication

pH dependencei

No decrease in activity was observed after incubating at pH 2.5 and at pH 11.0 overnight.1 Publication

Temperature dependencei

Thermostable. No decrease in activity was observed after heating for 1 hour at 90 degrees Celsius.1 Publication

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI01.059.

Names & Taxonomyi

Protein namesi
Recommended name:
Greglin
OrganismiSchistocerca gregaria (Desert locust)
Taxonomic identifieri7010 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaOrthopteraCaeliferaAcridomorphaAcridoideaAcrididaeCyrtacanthacridinaeSchistocerca

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8383GreglinPRO_0000271408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81Phosphoserine1 Publication
Modified residuei11 – 111Phosphoserine1 Publication
Modified residuei15 – 151Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

IntActiP85064. 1 interaction.
MINTiMINT-8397571.

Structurei

Secondary structure

1
83
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 263
Beta strandi32 – 365
Beta strandi41 – 466
Helixi47 – 5711
Beta strandi61 – 633
Helixi66 – 683

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GI3X-ray1.75C1-83[»]

Sequencei

Sequence statusi: Complete.

P85064-1 [UniParc]FASTAAdd to Basket

« Hide

SEDDGSVSPE SQEMSYLELP LPSISPLIYA PVCVEDSNSD FYLFVNECEV   50
RKCGCEAGFV YTFVPREMCK ATTSLCPMQT KSS 83
Length:83
Mass (Da):9,188
Last modified:June 16, 2009 - v2
Checksum:i0004698C2DF1B158
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GI3 X-ray 1.75 C 1-83 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P85064. 1 interaction.
MINTi MINT-8397571.

Protein family/group databases

MEROPSi I01.059.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "A novel locust (Schistocerca gregaria) serine protease inhibitor with a high affinity for neutrophil elastase."
    Brillard-Bourdet M., Hamdaoui A., Hajjar E., Boudier C., Reuter N., Ehret-Sabatier L., Bieth J.G., Gauthier F.
    Biochem. J. 400:467-476(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, PHOSPHORYLATION AT SER-8; SER-11 AND SER-15.
    Tissue: Ovary.

Entry informationi

Entry nameiSPI_SCHGR
AccessioniPrimary (citable) accession number: P85064
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 16, 2009
Last modified: April 16, 2014
This is version 15 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3