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P85064

- SPI_SCHGR

UniProt

P85064 - SPI_SCHGR

Protein

Greglin

Gene
N/A
Organism
Schistocerca gregaria (Desert locust)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Serine protease inhibitor. Inhibits porcine pancreatic elastase with a Ki of 58.3 nM, human neutrophil elastase with a Ki of 3.6 nM, cathepsin G with a Ki of 153.5 nM, chymotrypsin with a Ki of 26.7 nM and subtilisin with a Ki of 0.68 nM. Does not inhibit neutrophil protease 3 or pancreatic trypsin.1 Publication

    pH dependencei

    No decrease in activity was observed after incubating at pH 2.5 and at pH 11.0 overnight.1 Publication

    Temperature dependencei

    Thermostable. No decrease in activity was observed after heating for 1 hour at 90 degrees Celsius.1 Publication

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI01.059.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Greglin
    OrganismiSchistocerca gregaria (Desert locust)
    Taxonomic identifieri7010 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraOrthopteroideaOrthopteraCaeliferaAcridomorphaAcridoideaAcrididaeCyrtacanthacridinaeSchistocerca

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8383GreglinPRO_0000271408Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei8 – 81Phosphoserine1 Publication
    Modified residuei11 – 111Phosphoserine1 Publication
    Modified residuei15 – 151Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    IntActiP85064. 1 interaction.
    MINTiMINT-8397571.

    Structurei

    Secondary structure

    1
    83
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi24 – 263
    Beta strandi32 – 365
    Beta strandi41 – 466
    Helixi47 – 5711
    Beta strandi61 – 633
    Helixi66 – 683

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GI3X-ray1.75C1-83[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Sequencei

    Sequence statusi: Complete.

    P85064-1 [UniParc]FASTAAdd to Basket

    « Hide

    SEDDGSVSPE SQEMSYLELP LPSISPLIYA PVCVEDSNSD FYLFVNECEV   50
    RKCGCEAGFV YTFVPREMCK ATTSLCPMQT KSS 83
    Length:83
    Mass (Da):9,188
    Last modified:June 16, 2009 - v2
    Checksum:i0004698C2DF1B158
    GO

    Cross-referencesi

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GI3 X-ray 1.75 C 1-83 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P85064. 1 interaction.
    MINTi MINT-8397571.

    Protein family/group databases

    MEROPSi I01.059.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "A novel locust (Schistocerca gregaria) serine protease inhibitor with a high affinity for neutrophil elastase."
      Brillard-Bourdet M., Hamdaoui A., Hajjar E., Boudier C., Reuter N., Ehret-Sabatier L., Bieth J.G., Gauthier F.
      Biochem. J. 400:467-476(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, PHOSPHORYLATION AT SER-8; SER-11 AND SER-15.
      Tissue: Ovary1 Publication.

    Entry informationi

    Entry nameiSPI_SCHGR
    AccessioniPrimary (citable) accession number: P85064
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 16 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3