Reviewed, UniProtKB/Swiss-Prot P85051 (DYR1A_RABIT)

Names and origin

Protein names

Recommended name:
    Dual specificity tyrosine-phosphorylation-regulated kinase 1A
    EC=2.7.12.2
Alternative name(s):
    Protein kinase minibrain homolog
      Short name=MNBH
    RP86
    Dual specificity YAK1-related kinase

Gene names

Name:	DYRK1A
Synonyms:	DYRK

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	200 AA.
Sequence status	Fragments.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates. Ref.1
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Enzyme regulation	Inhibited by RANBP9 By similarity. UniProtKB Q13627
Subunit structure	Interacts with RANBP9. Interacts with RAD54L2/ARIP4 By similarity. Interacts with WDR68 By similarity.
Subcellular location	Nucleus Ref.1.
Post-translational modification	Autophosphorylated on tyrosine residues. Ref.1
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	protein amino acid autophosphorylation Ref.1 Inferred from direct assay. Source: UniProtKB
Cellular component	nuclear speck Ref.1 Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Ref.1 Inferred from direct assay. Source: UniProtKB protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›200	›200	Dual specificity tyrosine-phosphorylation-regulated kinase 1A		PRO_0000271242
Sites
	Binding site	58	1	ATP By similarity UniProtKB Q63470
Amino acid modifications
	Modified residue	76	1	Phosphotyrosine; by autocatalysis By similarity UniProtKB Q63470
Experimental info
	Non-adjacent residues	36 – 37	2
	Non-adjacent residues	49 – 50	2
	Non-adjacent residues	58 – 59	2
	Non-adjacent residues	69 – 70	2
	Non-adjacent residues	82 – 83	2
	Non-adjacent residues	95 – 96	2
	Non-adjacent residues	113 – 114	2
	Non-adjacent residues	126 – 127	2
	Non-adjacent residues	142 – 143	2
	Non-adjacent residues	149 – 150	2
	Non-adjacent residues	156 – 157	2
	Non-adjacent residues	169 – 170	2
	Non-terminal residue	1	1
	Non-terminal residue	200	1

Sequences

	Sequence		Length	Mass (Da)
	P85051-1 [UniParc]. Last modified January 9, 2007. Version 1. Checksum: 9ACA2DC506146E90	FASTA	200	22,896
	10 20 30 40 50 60 QPSISDQQVS ALPYSDQIQQ PLTNQVMPDI VMLQRRWMDR YEIDSLIGKV EQEWVAIKAF 70 80 90 100 110 120 LNQAQIEVRH DTEMKYYIVH LKIVDFGSSC QLGQRIVEVL GIPPAHILDQ APKFFEKLPD 130 140 150 160 170 180 GTWSLKKLHN ILGVETGGPG GRFKDLILRM LDYDPKIQPY YALQHSFFKQ ETGIAGHPTY 190 200 QFSANTGPAH YMTEGHLAMR

References

[1]

"The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site." Woods Y.L., Rena G., Morrice N., Barthel A., Becker W., Guo S., Unterman T.G., Cohen P. Biochem. J. 355:597-607(2001) [PubMed: 11311120] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AUTOPHOSPHORYLATION. Strain: New Zealand white. Tissue: Skeletal muscle.

Cross-references

3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	P85051.
Phylogenomic databases
eggNOG	maNOG07395.
HOVERGEN	P85051.
Enzyme and pathway databases
BRENDA	2.7.12.2. 255.
Family and domain databases
PROSITE	PS00107. PROTEIN_KINASE_ATP. Partial match. PS50011. PROTEIN_KINASE_DOM. Partial match. PS00108. PROTEIN_KINASE_ST. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DYR1A_RABIT

Accession

Primary (citable) accession number: P85051

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	January 19, 2010
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)