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Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Gene

DYRK1A

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Enzyme regulationi

Inhibited by RANBP9.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei58ATPPROSITE-ProRule annotationBy similarity1

GO - Molecular functioni

GO - Biological processi

  • circadian rhythm Source: UniProtKB
  • protein autophosphorylation Source: UniProtKB
  • protein phosphorylation Source: UniProtKB

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC:2.7.12.21 Publication)
Alternative name(s):
Dual specificity YAK1-related kinase
Protein kinase minibrain homolog
Short name:
MNBH
RP86
Gene namesi
Name:DYRK1A1 Publication
Synonyms:DYRKBy similarity
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000271242‹1 – ›200Dual specificity tyrosine-phosphorylation-regulated kinase 1AAdd BLAST›200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei76Phosphotyrosine; by autocatalysisBy similarity1
Modified residuei88Phosphoserine; by autocatalysisBy similarity1
Modified residuei122Phosphothreonine; by autocatalysisBy similarity1

Post-translational modificationi

Can also autophosphorylate on serine and threonine residues (in vitro) (By similarity). Autophosphorylated on numerous tyrosine residues.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with RANBP9 (By similarity). Interacts with RAD54L2/ARIP4 (By similarity). Interacts with CRY2 (By similarity). Interacts with WDR68 (By similarity). Interacts with SIRT1 (By similarity).By similarity

Protein-protein interaction databases

CORUMiP85051.

Structurei

3D structure databases

SMRiP85051.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR028318. DYRK1A/MNB.
PANTHERiPTHR24058:SF28. PTHR24058:SF28. 4 hits.

Sequencei

Sequence statusi: Fragments.

P85051-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QPSISDQQVS ALPYSDQIQQ PLTNQVMPDI VMLQRRWMDR YEIDSLIGKV
60 70 80 90 100
EQEWVAIKAF LNQAQIEVRH DTEMKYYIVH LKIVDFGSSC QLGQRIVEVL
110 120 130 140 150
GIPPAHILDQ APKFFEKLPD GTWSLKKLHN ILGVETGGPG GRFKDLILRM
160 170 180 190 200
LDYDPKIQPY YALQHSFFKQ ETGIAGHPTY QFSANTGPAH YMTEGHLAMR
Length:200
Mass (Da):22,896
Last modified:January 9, 2007 - v1
Checksum:i9ACA2DC506146E90
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11 Publication1
Non-adjacent residuesi36 – 371 Publication2
Non-adjacent residuesi49 – 501 Publication2
Non-adjacent residuesi58 – 591 Publication2
Non-adjacent residuesi69 – 701 Publication2
Non-adjacent residuesi82 – 831 Publication2
Non-adjacent residuesi95 – 961 Publication2
Non-adjacent residuesi113 – 1141 Publication2
Non-adjacent residuesi126 – 1271 Publication2
Non-adjacent residuesi142 – 1431 Publication2
Non-adjacent residuesi149 – 1501 Publication2
Non-adjacent residuesi156 – 1571 Publication2
Non-adjacent residuesi169 – 1701 Publication2
Non-terminal residuei2001 Publication1

Entry informationi

Entry nameiDYR1A_RABIT
AccessioniPrimary (citable) accession number: P85051
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: October 25, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families