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Alpha-conotoxin-like Reg1e

Conus regius (Crown cone)
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli


Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.By similarity

GO - Molecular functioni


Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin-like Reg1e1 Publication
OrganismiConus regius (Crown cone)
Taxonomic identifieri101314 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConusStephanoconus

Organism-specific databases

ConoServeri30. Reg1e.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti


PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00002593871 – 12Alpha-conotoxin-like Reg1e1 PublicationAdd BLAST12

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi2 ↔ 8By similarity
Disulfide bondi3 ↔ 12By similarity
Modified residuei64-hydroxyproline1 Publication1
Modified residuei12Cysteine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond, Hydroxylation


Tissue specificityi

Expressed by the venom duct.1 Publication

Family & Domainsi


The cysteine framework is I (CC-C-C). Alpha4/3 pattern.Curated

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR018072. Conotoxin_a-typ_CS.
PROSITEiView protein in PROSITE
PS60014. ALPHA_CONOTOXIN. 1 hit.


Sequence statusi: Complete.

Mass (Da):1,419
Last modified:October 31, 2006 - v1

Similar proteinsi

Entry informationi

Entry nameiCA1E_CONRE
AccessioniPrimary (citable) accession number: P85011
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: January 31, 2018
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program



Has the same mature sequence than RgIA (AC P0C1D0). RgIA could therefore be the precursor of Reg1e, except that RgIA does not have the C-terminal Gly residue required for C-terminal amidation of Reg1e.Curated

Keywords - Technical termi

Direct protein sequencing