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Protein

Bacteriocin divergicin M35

Gene
N/A
Organism
Carnobacterium divergens (Lactobacillus divergens)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Bacteriocin with antibacterial activity against many strains of L.monocytogenes, L.seeligeri, L.welshimeri, L.grayi, L.murayi, L.ivanovii, L.innocus, C.divergens and C.piscocola. No antibacterial activity was detected against L.lactis, P.acidilactici, P.pentosaceus, L.salivarius, L.delbruekii, L.acidophilus, L.plantarum, L.casei, L.rhamnosus, S.thermophilus, P.freudenreichii, B.breve and E.coli.1 Publication

Temperature dependencei

Displays a high degree of stability when incubated at temperatures of up to 121 degrees Celsius for 60 minutes.1 Publication

GO - Biological processi

  • cytolysis Source: UniProtKB-KW
  • defense response to Gram-positive bacterium Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriocin

Protein family/group databases

TCDBi1.C.24.1.13. the pediocin (pediocin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacteriocin divergicin M35
OrganismiCarnobacterium divergens (Lactobacillus divergens)
Taxonomic identifieri2748 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesCarnobacteriaceaeCarnobacterium

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Biotechnological usei

Has potential for use as a biopreservative for inhibiting L.monocytogenes in seafood products that do not usually undergo an adequate heat treatment.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00002506061 – 43Bacteriocin divergicin M35Add BLAST43

Structurei

3D structure databases

ProteinModelPortaliP84962.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bacteriocin class IIA/YGNGV family.Sequence analysis

Family and domain databases

Gene3Di1.20.5.130. 1 hit.
InterProiIPR002633. Bacteriocin_IIa.
IPR023384. Bacteriocin_IIa_CS.
IPR023388. Bacteriocin_IIa_dom.
[Graphical view]
PfamiPF01721. Bacteriocin_II. 1 hit.
[Graphical view]
ProDomiPD004452. Bacteriocin_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS60030. BACTERIOCIN_IIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P84962-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
TKYYGNGVYC NSKKCWVDWG TAQGCIDVVI GQLGGGIPGK GKC
Length:43
Mass (Da):4,525
Last modified:October 3, 2006 - v1
Checksum:i3370AC1734B4DF55
GO

Mass spectrometryi

Molecular mass is 4518.75 Da from positions 1 - 43. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

ProteinModelPortaliP84962.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.24.1.13. the pediocin (pediocin) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.5.130. 1 hit.
InterProiIPR002633. Bacteriocin_IIa.
IPR023384. Bacteriocin_IIa_CS.
IPR023388. Bacteriocin_IIa_dom.
[Graphical view]
PfamiPF01721. Bacteriocin_II. 1 hit.
[Graphical view]
ProDomiPD004452. Bacteriocin_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS60030. BACTERIOCIN_IIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDIV35_CARDV
AccessioniPrimary (citable) accession number: P84962
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: December 9, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.