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Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli


May produce in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle (By similarity). May target bradykinin receptors (BDKRB).By similarity

GO - Molecular functioni

GO - Biological processi


Molecular functionAmphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

Names & Taxonomyi

Protein namesi
Recommended name:
[Val1,Hyp2,Thr6]-bradykinyl-Gln,Ser1 Publication
Alternative name(s):
[Val1,Hyp2,Thr6]-bradykinin-Gln,Ser1 Publication
OrganismiPhyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)
Taxonomic identifieri394475 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaePhyllomedusinaePhyllomedusa

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti


PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00002504261 – 11[Val1,Hyp2,Thr6]-bradykinyl-Gln,Ser1 PublicationAdd BLAST11

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24-hydroxyproline1 Publication1

Keywords - PTMi



Tissue specificityi

Expressed by the skin glands.1 Publication


GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the bradykinin-related peptide family.Curated

Phylogenomic databases


Family and domain databases

InterProiView protein in InterPro
IPR009608. Bradykinin.
PfamiView protein in Pfam
PF06753. Bradykinin. 1 hit.


Sequence statusi: Complete.

Mass (Da):1,232
Last modified:October 3, 2006 - v1

Mass spectrometryi

Molecular mass is 1247.75 Da from positions 1 - 11. Determined by MALDI. 1 Publication

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBRK3_PHYAZ
AccessioniPrimary (citable) accession number: P84935
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: May 10, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program


Keywords - Technical termi

Direct protein sequencing


  1. SIMILARITY comments
    Index of protein domains and families