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P84935

- BRK3_PHYAZ

UniProt

P84935 - BRK3_PHYAZ

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Protein

[Val1,Hyp2,Thr6]-bradykinyl-Gln,Ser

Gene
N/A
Organism
Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May produce in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle By similarity. May target bradykinin receptors (BDKRB).

GO - Biological processi

  1. defense response Source: UniProtKB-KW
  2. vasodilation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

Names & Taxonomyi

Protein namesi
Recommended name:
[Val1,Hyp2,Thr6]-bradykinyl-Gln,Ser
Alternative name(s):
[Val1,Hyp2,Thr6]-bradykinin-Gln,Ser
OrganismiPhyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)
Taxonomic identifieri394475 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaePhyllomedusinaePhyllomedusa

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 1111[Val1,Hyp2,Thr6]-bradykinyl-Gln,Ser1 PublicationPRO_0000250426Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 214-hydroxyproline1 Publication

Keywords - PTMi

Hydroxylation

Expressioni

Tissue specificityi

Expressed by the skin glands.1 Publication

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG080927.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P84935-1 [UniParc]FASTAAdd to Basket

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VPPGFTPFRQ S                                             11
Length:11
Mass (Da):1,232
Last modified:October 3, 2006 - v1
Checksum:i2BF39687D771A9C8
GO

Mass spectrometryi

Molecular mass is 1247.75 Da from positions 1 - 11. Determined by MALDI. 1 Publication

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG080927.

Family and domain databases

InterProi IPR009608. Bradykinin.
[Graphical view ]
Pfami PF06753. Bradykinin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bradykinin-related peptides from Phyllomedusa hypochondrialis azurea: Mass spectrometric structural characterisation and cloning of precursor cDNAs."
    Thompson A.H., Bjourson A.J., Shaw C., McClean S.
    Rapid Commun. Mass Spectrom. 20:3780-3788(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY, HYDROXYLATION AT PRO-2.
    Tissue: Skin secretion.

Entry informationi

Entry nameiBRK3_PHYAZ
AccessioniPrimary (citable) accession number: P84935
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 13, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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