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P84935

- BRK3_PHYAZ

UniProt

P84935 - BRK3_PHYAZ

Protein

[Val1,Hyp2,Thr6]-bradykinyl-Gln,Ser

Gene
N/A
Organism
Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May produce in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle By similarity. May target bradykinin receptors (BDKRB).By similarity

    GO - Biological processi

    1. defense response Source: UniProtKB-KW
    2. vasodilation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Amphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    [Val1,Hyp2,Thr6]-bradykinyl-Gln,Ser1 Publication
    Alternative name(s):
    [Val1,Hyp2,Thr6]-bradykinin-Gln,Ser1 Publication
    OrganismiPhyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)
    Taxonomic identifieri394475 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaePhyllomedusinaePhyllomedusa

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 1111[Val1,Hyp2,Thr6]-bradykinyl-Gln,Ser1 PublicationPRO_0000250426Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 214-hydroxyproline1 Publication

    Keywords - PTMi

    Hydroxylation

    Expressioni

    Tissue specificityi

    Expressed by the skin glands.1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the bradykinin-related peptide family.Curated

    Phylogenomic databases

    HOVERGENiHBG080927.

    Family and domain databases

    InterProiIPR009608. Bradykinin.
    [Graphical view]
    PfamiPF06753. Bradykinin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P84935-1 [UniParc]FASTAAdd to Basket

    « Hide

    VPPGFTPFRQ S                                             11
    Length:11
    Mass (Da):1,232
    Last modified:October 3, 2006 - v1
    Checksum:i2BF39687D771A9C8
    GO

    Mass spectrometryi

    Molecular mass is 1247.75 Da from positions 1 - 11. Determined by MALDI. 1 Publication

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG080927.

    Family and domain databases

    InterProi IPR009608. Bradykinin.
    [Graphical view ]
    Pfami PF06753. Bradykinin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bradykinin-related peptides from Phyllomedusa hypochondrialis azurea: Mass spectrometric structural characterisation and cloning of precursor cDNAs."
      Thompson A.H., Bjourson A.J., Shaw C., McClean S.
      Rapid Commun. Mass Spectrom. 20:3780-3788(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY, HYDROXYLATION AT PRO-2.
      Tissue: Skin secretion1 Publication.

    Entry informationi

    Entry nameiBRK3_PHYAZ
    AccessioniPrimary (citable) accession number: P84935
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3