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P84935 (BRK3_PHYAZ) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
[Val1,Hyp2,Thr6]-bradykinyl-Gln,Ser
Alternative name(s):
[Val1,Hyp2,Thr6]-bradykinin-Gln,Ser
OrganismPhyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)
Taxonomic identifier394475 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaePhyllomedusinaePhyllomedusa

Protein attributes

Sequence length11 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May produce in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle By similarity. May target bradykinin receptors (BDKRB).

Subcellular location

Secreted Ref.1.

Tissue specificity

Expressed by the skin glands. Ref.1

Sequence similarities

Belongs to the bradykinin-related peptide family.

Mass spectrometry

Molecular mass is 1247.75 Da from positions 1 - 11. Determined by MALDI. Ref.1

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionAmphibian defense peptide
G-protein coupled receptor impairing toxin
Toxin
Vasoactive
Vasodilator
   PTMHydroxylation
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processdefense response

Inferred from electronic annotation. Source: UniProtKB-KW

vasodilation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 1111[Val1,Hyp2,Thr6]-bradykinyl-Gln,Ser Ref.1
PRO_0000250426

Amino acid modifications

Modified residue214-hydroxyproline Ref.1

Sequences

Sequence LengthMass (Da)Tools
P84935 [UniParc].

Last modified October 3, 2006. Version 1.
Checksum: 2BF39687D771A9C8

FASTA111,232
        10 
VPPGFTPFRQ S 

« Hide

References

[1]"Bradykinin-related peptides from Phyllomedusa hypochondrialis azurea: Mass spectrometric structural characterisation and cloning of precursor cDNAs."
Thompson A.H., Bjourson A.J., Shaw C., McClean S.
Rapid Commun. Mass Spectrom. 20:3780-3788(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY, HYDROXYLATION AT PRO-2.
Tissue: Skin secretion.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG080927.

Family and domain databases

InterProIPR009608. Bradykinin.
[Graphical view]
PfamPF06753. Bradykinin. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBRK3_PHYAZ
AccessionPrimary (citable) accession number: P84935
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 13, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families