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Protein

[Val1,Thr6]-bradykinyl-Gln,Ser

Gene
N/A
Organism
Phyllomedusa hypochondrialis (Orange-legged leaf frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle (By similarity). Produces smooth muscle contraction in guinea pig ileum. May target bradykinin receptors (BDKRB).By similarity1 Publication

GO - Biological processi

  1. defense response Source: UniProtKB-KW
  2. vasodilation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

Names & Taxonomyi

Protein namesi
Recommended name:
[Val1,Thr6]-bradykinyl-Gln,Ser
OrganismiPhyllomedusa hypochondrialis (Orange-legged leaf frog)
Taxonomic identifieri317381 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaePhyllomedusinaePhyllomedusa

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 1111[Val1,Thr6]-bradykinyl-Gln,Ser1 PublicationPRO_0000248469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 214-hydroxyproline; in form [Val1,Hyp2, Thr6]-Bradykinyl-Gln,Ser1 Publication

Keywords - PTMi

Hydroxylation

Expressioni

Tissue specificityi

Expressed by the skin glands.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the bradykinin-related peptide family.Curated

Phylogenomic databases

HOVERGENiHBG080927.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Length:11
Mass (Da):1,232
Last modified:September 5, 2006 - v1
Checksum:i2BF39687D771A9C8
GO

Mass spectrometryi

Molecular mass is 1232.66±0.1 Da from positions 1 - 11. Determined by MALDI. 1 Publication
Molecular mass is 1248.69±0.1 Da from positions 1 - 11. Determined by MALDI. Hydroxylated.1 Publication

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG080927.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, HYDROXYLATION AT PRO-2.
    Tissue: Skin secretion1 Publication.

Entry informationi

Entry nameiBRK8_PHYHY
AccessioniPrimary (citable) accession number: P84899
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: January 7, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.