Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P84899

- BRK8_PHYHY

UniProt

P84899 - BRK8_PHYHY

Protein

[Val1,Thr6]-bradykinyl-Gln,Ser

Gene
N/A
Organism
Phyllomedusa hypochondrialis (Orange-legged leaf frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Produces in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle By similarity. Produces smooth muscle contraction in guinea pig ileum. May target bradykinin receptors (BDKRB).By similarity1 Publication

    GO - Biological processi

    1. defense response Source: UniProtKB-KW
    2. vasodilation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Amphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    [Val1,Thr6]-bradykinyl-Gln,Ser
    OrganismiPhyllomedusa hypochondrialis (Orange-legged leaf frog)
    Taxonomic identifieri317381 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaePhyllomedusinaePhyllomedusa

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 1111[Val1,Thr6]-bradykinyl-Gln,Ser1 PublicationPRO_0000248469Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 214-hydroxyproline; in form [Val1,Hyp2, Thr6]-Bradykinyl-Gln,Ser1 Publication

    Keywords - PTMi

    Hydroxylation

    Expressioni

    Tissue specificityi

    Expressed by the skin glands.1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the bradykinin-related peptide family.Curated

    Phylogenomic databases

    HOVERGENiHBG080927.

    Family and domain databases

    InterProiIPR009608. Bradykinin.
    [Graphical view]
    PfamiPF06753. Bradykinin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P84899-1 [UniParc]FASTAAdd to Basket

    « Hide

    VPPGFTPFRQ S                                             11
    Length:11
    Mass (Da):1,232
    Last modified:September 5, 2006 - v1
    Checksum:i2BF39687D771A9C8
    GO

    Mass spectrometryi

    Molecular mass is 1232.66±0.1 Da from positions 1 - 11. Determined by MALDI. 1 Publication
    Molecular mass is 1248.69±0.1 Da from positions 1 - 11. Determined by MALDI. Hydroxylated.1 Publication

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG080927.

    Family and domain databases

    InterProi IPR009608. Bradykinin.
    [Graphical view ]
    Pfami PF06753. Bradykinin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, HYDROXYLATION AT PRO-2.
      Tissue: Skin secretion1 Publication.

    Entry informationi

    Entry nameiBRK8_PHYHY
    AccessioniPrimary (citable) accession number: P84899
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3