UniProtKB - P84889 (VANG2_RAT)
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Protein
Vang-like protein 2
Gene
Vangl2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity).By similarity
GO - Biological processi
- anterior/posterior pattern specification Source: RGD
- apical protein localization Source: RGD
- cell migration involved in kidney development Source: RGD
- cochlea development Source: RGD
- cochlea morphogenesis Source: RGD
- convergent extension involved in axis elongation Source: RGD
- convergent extension involved in neural plate elongation Source: RGD
- convergent extension involved in organogenesis Source: RGD
- digestive tract morphogenesis Source: RGD
- dopaminergic neuron axon guidance Source: RGD
- establishment of body hair planar orientation Source: RGD
- establishment of planar polarity Source: RGD
- establishment of planar polarity involved in neural tube closure Source: RGD
- establishment or maintenance of epithelial cell apical/basal polarity Source: RGD
- glomerulus development Source: RGD
- hair follicle development Source: RGD
- heart looping Source: RGD
- heparan sulfate proteoglycan biosynthetic process Source: RGD
- inner ear receptor cell development Source: RGD
- inner ear receptor cell stereocilium organization Source: RGD
- kidney morphogenesis Source: RGD
- lateral sprouting involved in lung morphogenesis Source: RGD
- membranous septum morphogenesis Source: RGD
- muscular septum morphogenesis Source: RGD
- neural tube closure Source: RGD
- non-canonical Wnt signaling pathway Source: RGD
- non-motile cilium assembly Source: RGD
- orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis Source: RGD
- planar cell polarity pathway involved in axis elongation Source: RGD
- planar cell polarity pathway involved in axon guidance Source: RGD
- planar cell polarity pathway involved in heart morphogenesis Source: RGD
- planar cell polarity pathway involved in neural tube closure Source: RGD
- planar dichotomous subdivision of terminal units involved in lung branching morphogenesis Source: RGD
- positive regulation of JUN kinase activity Source: RGD
- post-anal tail morphogenesis Source: RGD
- regulation of actin cytoskeleton organization Source: RGD
- regulation of establishment of planar polarity Source: RGD
- regulation of Wnt signaling pathway Source: RGD
- Rho protein signal transduction Source: RGD
- serotonergic neuron axon guidance Source: RGD
- somatic stem cell division Source: RGD
- somatic stem cell population maintenance Source: RGD
- Wnt signaling pathway, planar cell polarity pathway Source: RGD
- wound healing Source: RGD
Keywordsi
Molecular function | Developmental protein |
Names & Taxonomyi
Protein namesi | Recommended name: Vang-like protein 2Alternative name(s): Van Gogh-like protein 2 |
Gene namesi | Name:Vangl2Imported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1309442. Vangl2. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 108 | CytoplasmicSequence analysisAdd BLAST | 108 | |
Transmembranei | 109 – 129 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 130 – 147 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 148 – 168 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 169 – 178 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 179 – 199 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 200 – 217 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 218 – 238 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 239 – 521 | CytoplasmicSequence analysisAdd BLAST | 283 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247591 | 1 – 521 | Vang-like protein 2Add BLAST | 521 |
Proteomic databases
PaxDbi | P84889. |
PRIDEi | P84889. |
PTM databases
iPTMneti | P84889. |
PhosphoSitePlusi | P84889. |
SwissPalmi | P84889. |
Expressioni
Tissue specificityi
Asymmetrically localized to specific cell-cell boundaries in the developing inner ear.1 Publication
Developmental stagei
Expression does not persist beyond the early postnatal period in the sensory region of the inner ear.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000004889. |
Genevisiblei | P84889. RN. |
Interactioni
Subunit structurei
Homodimer and heterodimer with VANGL1. Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3 (By similarity).By similarity
Protein-protein interaction databases
BioGridi | 252835. 4 interactors. |
CORUMi | P84889. |
IntActi | P84889. 4 interactors. |
MINTi | P84889. |
STRINGi | 10116.ENSRNOP00000006849. |
Family & Domainsi
Sequence similaritiesi
Belongs to the Vang family.Sequence analysis
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3814. Eukaryota. ENOG410XPVT. LUCA. |
GeneTreei | ENSGT00390000012496. |
HOGENOMi | HOG000230590. |
HOVERGENi | HBG058215. |
InParanoidi | P84889. |
KOi | K04510. |
OMAi | TIQYHKD. |
OrthoDBi | EOG091G056W. |
PhylomeDBi | P84889. |
TreeFami | TF313467. |
Family and domain databases
InterProi | View protein in InterPro IPR009539. VANGL. |
PANTHERi | PTHR20886. PTHR20886. 1 hit. |
Pfami | View protein in Pfam PF06638. Strabismus. 1 hit. |
PIRSFi | PIRSF007991. Strabismus. 1 hit. |
i Sequence
Sequence statusi: Complete.
P84889-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTESQYSGY SYKSGHSRSS RKHRDRRDRH RSKSRDGSRG DKSVTIQAPG
60 70 80 90 100
EPLLDNESTR GDERDDNWGE TTTVVTGTSE HSISHDDLTR IAKDMEDSVP
110 120 130 140 150
LDCSRHLGVA AGAILALLSF LTPLAFLLLP PLLWREELEP CGTACEGLFI
160 170 180 190 200
SVAFKLLILL LGSWALFFRR PKASLPRVFV LRALLMVLVF LLVISYWLFY
210 220 230 240 250
GVRILDARER SYQGVVQFAV SLVDALLFVH YLAVVLLELR QLQPQFTLKV
260 270 280 290 300
VRSTDGASRF YNVGHLSIQR VAVWILEKYY HDFPVYNPAL LNLPKSVLAK
310 320 330 340 350
KVSGFKVYSL GEENSTNNST GQSRAVIAAA ARRRDNSHNE YYYEEAEHER
360 370 380 390 400
RVRKRRARLV VAVEEAFTHI KRLQEEEQKN PREVMDPREA AQAIFASMAR
410 420 430 440 450
AMQKYLRTTK QQPYHTMESI LQHLEFCITH DMTPKAFLER YLAAGPTIQY
460 470 480 490 500
HKERWLAKQW TLVSEEPVTN GLKDGIVFLL KRQDFSLVVS TKKVPFFKLS
510 520
EEFVDPKSHK FVMRLQSETS V
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR03084676 Genomic DNA. No translation available. |
RefSeqi | NP_001099439.1. NM_001105969.1. XP_006250338.1. XM_006250276.3. XP_006250339.1. XM_006250277.3. XP_017454201.1. XM_017598712.1. XP_017454202.1. XM_017598713.1. |
UniGenei | Rn.198958. |
Genome annotation databases
Ensembli | ENSRNOT00000006849; ENSRNOP00000006849; ENSRNOG00000004889. ENSRNOT00000091710; ENSRNOP00000072619; ENSRNOG00000004889. |
GeneIDi | 289229. |
KEGGi | rno:289229. |
UCSCi | RGD:1309442. rat. |
Similar proteinsi
Entry informationi
Entry namei | VANG2_RAT | |
Accessioni | P84889Primary (citable) accession number: P84889 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | July 25, 2006 | |
Last modified: | February 28, 2018 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |