Vangl2

Functionⁱ

Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity).By similarity

GO - Biological processⁱ

anterior/posterior pattern specification Source: Ensembl
apical protein localization Source: Ensembl
cell migration involved in kidney development Source: Ensembl
cochlea morphogenesis Source: Ensembl
convergent extension involved in axis elongation Source: Ensembl
convergent extension involved in neural plate elongation Source: Ensembl
digestive tract morphogenesis Source: Ensembl
dopaminergic neuron axon guidance Source: Ensembl
establishment of body hair planar orientation Source: Ensembl
establishment of planar polarity involved in neural tube closure Source: Ensembl
establishment or maintenance of epithelial cell apical/basal polarity Source: Ensembl
glomerulus development Source: Ensembl
hair follicle development Source: Ensembl
heart looping Source: Ensembl
heparan sulfate proteoglycan biosynthetic process Source: Ensembl
inner ear receptor stereocilium organization Source: Ensembl
kidney morphogenesis Source: Ensembl
lateral sprouting involved in lung morphogenesis Source: Ensembl
membranous septum morphogenesis Source: Ensembl
muscular septum morphogenesis Source: Ensembl
non-motile cilium assembly Source: Ensembl
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis Source: Ensembl
planar cell polarity pathway involved in axis elongation Source: Ensembl
planar cell polarity pathway involved in axon guidance Source: Ensembl
planar cell polarity pathway involved in heart morphogenesis Source: Ensembl
planar cell polarity pathway involved in neural tube closure Source: Ensembl
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis Source: Ensembl
positive regulation of JUN kinase activity Source: Ensembl
post-anal tail morphogenesis Source: Ensembl
regulation of actin cytoskeleton organization Source: Ensembl
regulation of Wnt signaling pathway Source: Ensembl
Rho protein signal transduction Source: Ensembl
serotonergic neuron axon guidance Source: Ensembl
somatic stem cell division Source: Ensembl
somatic stem cell population maintenance Source: Ensembl
wound healing Source: Ensembl

Complete GO annotation...

Keywordsⁱ

Molecular function	Developmental protein

Molecular function

Developmental protein

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Vang-like protein 2 Alternative name(s): Van Gogh-like protein 2
Gene namesⁱ	Name:Vangl2Imported
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 13

Organism-specific databases

Rat genome database More...RGDⁱ	1309442. Vangl2.

RGDⁱ

1309442. Vangl2.

Subcellular locationⁱ

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 108	CytoplasmicSequence analysisAdd BLAST	108
Transmembraneⁱ	109 – 129	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	130 – 147	ExtracellularSequence analysisAdd BLAST	18
Transmembraneⁱ	148 – 168	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	169 – 178	CytoplasmicSequence analysis	10
Transmembraneⁱ	179 – 199	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	200 – 217	ExtracellularSequence analysisAdd BLAST	18
Transmembraneⁱ	218 – 238	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	239 – 521	CytoplasmicSequence analysisAdd BLAST	283

GO - Cellular componentⁱ

apical plasma membrane Source: Ensembl
basolateral plasma membrane Source: Ensembl
cell-cell junction Source: Ensembl
cell pole Source: Ensembl
ER to Golgi transport vesicle Source: Ensembl
integral component of membrane Source: UniProtKB-KW
lateral plasma membrane Source: Ensembl
stress fiber Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000247591	1 – 521	Vang-like protein 2Add BLAST		521

Proteomic databases

PaxDbⁱ	P84889.
PRIDEⁱ	P84889.

PTM databases

iPTMnetⁱ	P84889.
PhosphoSitePlusⁱ	P84889.
SwissPalmⁱ	P84889.

Expressionⁱ

Tissue specificityⁱ

Asymmetrically localized to specific cell-cell boundaries in the developing inner ear.1 Publication

Developmental stageⁱ

Expression does not persist beyond the early postnatal period in the sensory region of the inner ear.1 Publication

Gene expression databases

Bgeeⁱ	ENSRNOG00000004889.
Genevisibleⁱ	P84889. RN.

Interactionⁱ

Subunit structureⁱ

Homodimer and heterodimer with VANGL1. Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3 (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	252835. 4 interactors.
IntActⁱ	P84889. 4 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-8416720.
STRINGⁱ	10116.ENSRNOP00000006849.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P84889.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the Vang family.Sequence analysis

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3814. Eukaryota. ENOG410XPVT. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012496.
HOGENOMⁱ	HOG000230590.
HOVERGENⁱ	HBG058215.
InParanoidⁱ	P84889.
KEGG Orthology (KO) More...KOⁱ	K04510.
OMAⁱ	TIQYHKD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G056W.
PhylomeDBⁱ	P84889.
TreeFamⁱ	TF313467.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009539. VANGL.
PANTHERⁱ	PTHR20886. PTHR20886. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06638. Strabismus. 1 hit.
PIRSFⁱ	PIRSF007991. Strabismus. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P84889-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDTESQYSGY SYKSGHSRSS RKHRDRRDRH RSKSRDGSRG DKSVTIQAPG 
        60         70         80         90        100
EPLLDNESTR GDERDDNWGE TTTVVTGTSE HSISHDDLTR IAKDMEDSVP 
       110        120        130        140        150
LDCSRHLGVA AGAILALLSF LTPLAFLLLP PLLWREELEP CGTACEGLFI 
       160        170        180        190        200
SVAFKLLILL LGSWALFFRR PKASLPRVFV LRALLMVLVF LLVISYWLFY 
       210        220        230        240        250
GVRILDARER SYQGVVQFAV SLVDALLFVH YLAVVLLELR QLQPQFTLKV 
       260        270        280        290        300
VRSTDGASRF YNVGHLSIQR VAVWILEKYY HDFPVYNPAL LNLPKSVLAK 
       310        320        330        340        350
KVSGFKVYSL GEENSTNNST GQSRAVIAAA ARRRDNSHNE YYYEEAEHER 
       360        370        380        390        400
RVRKRRARLV VAVEEAFTHI KRLQEEEQKN PREVMDPREA AQAIFASMAR 
       410        420        430        440        450
AMQKYLRTTK QQPYHTMESI LQHLEFCITH DMTPKAFLER YLAAGPTIQY 
       460        470        480        490        500
HKERWLAKQW TLVSEEPVTN GLKDGIVFLL KRQDFSLVVS TKKVPFFKLS 
       510        520 
EEFVDPKSHK FVMRLQSETS V

Length:521

Mass (Da):59,771

Last modified:July 25, 2006 - v1

Checksum:ⁱ94ECEF3EE63DF5BC

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR03084676 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001099439.1. NM_001105969.1. XP_006250338.1. XM_006250276.3. XP_006250339.1. XM_006250277.3. XP_017454201.1. XM_017598712.1. XP_017454202.1. XM_017598713.1.
UniGeneⁱ	Rn.198958.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000006849; ENSRNOP00000006849; ENSRNOG00000004889. ENSRNOT00000091710; ENSRNOP00000072619; ENSRNOG00000004889.
GeneIDⁱ	289229.
KEGGⁱ	rno:289229.
UCSC genome browser More...UCSCⁱ	RGD:1309442. rat.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AABR03084676 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001099439.1. NM_001105969.1. XP_006250338.1. XM_006250276.3. XP_006250339.1. XM_006250277.3. XP_017454201.1. XM_017598712.1. XP_017454202.1. XM_017598713.1.
UniGeneⁱ	Rn.198958.

3D structure databases

ProteinModelPortalⁱ	P84889.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	252835. 4 interactors.
IntActⁱ	P84889. 4 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-8416720.
STRINGⁱ	10116.ENSRNOP00000006849.

PTM databases

iPTMnetⁱ	P84889.
PhosphoSitePlusⁱ	P84889.
SwissPalmⁱ	P84889.

Proteomic databases

PaxDbⁱ	P84889.
PRIDEⁱ	P84889.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000006849; ENSRNOP00000006849; ENSRNOG00000004889. ENSRNOT00000091710; ENSRNOP00000072619; ENSRNOG00000004889.
GeneIDⁱ	289229.
KEGGⁱ	rno:289229.
UCSC genome browser More...UCSCⁱ	RGD:1309442. rat.

Organism-specific databases

CTDⁱ	57216.
Rat genome database More...RGDⁱ	1309442. Vangl2.

Phylogenomic databases

eggNOGⁱ	KOG3814. Eukaryota. ENOG410XPVT. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012496.
HOGENOMⁱ	HOG000230590.
HOVERGENⁱ	HBG058215.
InParanoidⁱ	P84889.
KEGG Orthology (KO) More...KOⁱ	K04510.
OMAⁱ	TIQYHKD.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G056W.
PhylomeDBⁱ	P84889.
TreeFamⁱ	TF313467.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P84889.

PROⁱ

PR:P84889.

Gene expression databases

Bgeeⁱ	ENSRNOG00000004889.
Genevisibleⁱ	P84889. RN.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009539. VANGL.
PANTHERⁱ	PTHR20886. PTHR20886. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06638. Strabismus. 1 hit.
PIRSFⁱ	PIRSF007991. Strabismus. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VANG2_RAT
Accessionⁱ	P84889Primary (citable) accession number: P84889
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
	Last sequence update:	July 25, 2006
	Last modified:	June 7, 2017
	This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P84889 (VANG2_RAT)

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Vang-like protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ