Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P84865

- MT1_NECLU

UniProt

P84865 - MT1_NECLU

Protein

Metallothionein

Gene
N/A
Organism
Nectria lugdunensis (Aquatic fungus) (Heliscus lugdunensis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Metallothioneins have a high content of cysteine residues that bind various heavy metals.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi3 – 31Cadmium1 Publication
    Metal bindingi5 – 51Cadmium1 Publication
    Metal bindingi8 – 81Cadmium1 Publication
    Metal bindingi10 – 101Cadmium1 Publication
    Metal bindingi14 – 141Cadmium1 Publication
    Metal bindingi17 – 171Cadmium1 Publication
    Metal bindingi19 – 191Cadmium1 Publication
    Metal bindingi22 – 221Cadmium1 Publication

    GO - Molecular functioni

    1. metal chelating activity Source: UniProtKB

    Keywords - Ligandi

    Cadmium, Metal-binding, Metal-thiolate cluster

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein
    OrganismiNectria lugdunensis (Aquatic fungus) (Heliscus lugdunensis)
    Taxonomic identifieri57155 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeNectria

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 2424Metallothionein1 PublicationPRO_0000244521Add
    BLAST

    Post-translational modificationi

    Contains 4 disulfide bonds.Curated

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Inductioni

    By cadmium.1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the metallothionein superfamily. Type 8 family.Sequence Analysis

    Sequencei

    Sequence statusi: Complete.

    P84865-1 [UniParc]FASTAAdd to Basket

    « Hide

    SPCTCSTCNC AGACNSCSCT SCSH                               24
    Length:24
    Mass (Da):2,331
    Last modified:June 27, 2006 - v1
    Checksum:i6568E5C8BE87E8FF
    GO

    Mass spectrometryi

    Molecular mass is 2321.5 Da from positions 1 - 24. Determined by MALDI. The measured mass is that of apo-metallothionein with intact disulfide bonds.1 Publication
    Molecular mass is 2329.7 Da from positions 1 - 24. Determined by MALDI. The measured mass is that of apo-metallothionein treated with acid to cleave disulfide bonds.1 Publication
    Molecular mass is 2431.5 Da from positions 1 - 24. Determined by MALDI. The measured mass is that of metallothionein with intact disulfide bonds chelating one cadmium ion.1 Publication
    Molecular mass is 2541.5 Da from positions 1 - 24. Determined by MALDI. The measured mass is that of metallothionein with intact disulfide bonds chelating 2 cadmium ions.1 Publication

    Cross-referencesi

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Cadmium induces a novel metallothionein and phytochelatin 2 in an aquatic fungus."
      Jaeckel P., Krauss G., Menge S., Schierhorn A., Ruecknagel P., Krauss G.J.
      Biochem. Biophys. Res. Commun. 333:150-155(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, FUNCTION, INDUCTION, MASS SPECTROMETRY, DISULFIDE BONDS, CADMIUM BINDING.
      Tissue: Mycelium1 Publication.

    Entry informationi

    Entry nameiMT1_NECLU
    AccessioniPrimary (citable) accession number: P84865
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3