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P84865

- MT1_NECLU

UniProt

P84865 - MT1_NECLU

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Protein

Metallothionein

Gene
N/A
Organism
Nectria lugdunensis (Aquatic fungus) (Heliscus lugdunensis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi3 – 31Cadmium1 Publication
Metal bindingi5 – 51Cadmium1 Publication
Metal bindingi8 – 81Cadmium1 Publication
Metal bindingi10 – 101Cadmium1 Publication
Metal bindingi14 – 141Cadmium1 Publication
Metal bindingi17 – 171Cadmium1 Publication
Metal bindingi19 – 191Cadmium1 Publication
Metal bindingi22 – 221Cadmium1 Publication

GO - Molecular functioni

  1. metal chelating activity Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Cadmium, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein
OrganismiNectria lugdunensis (Aquatic fungus) (Heliscus lugdunensis)
Taxonomic identifieri57155 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeNectria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 2424Metallothionein1 PublicationPRO_0000244521Add
BLAST

Post-translational modificationi

Contains 4 disulfide bonds.Curated

Keywords - PTMi

Disulfide bond

Expressioni

Inductioni

By cadmium.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the metallothionein superfamily. Type 8 family.Sequence Analysis

Sequencei

Sequence statusi: Complete.

P84865-1 [UniParc]FASTAAdd to Basket

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        10         20
SPCTCSTCNC AGACNSCSCT SCSH
Length:24
Mass (Da):2,331
Last modified:June 27, 2006 - v1
Checksum:i6568E5C8BE87E8FF
GO

Mass spectrometryi

Molecular mass is 2321.5 Da from positions 1 - 24. Determined by MALDI. The measured mass is that of apo-metallothionein with intact disulfide bonds.1 Publication
Molecular mass is 2329.7 Da from positions 1 - 24. Determined by MALDI. The measured mass is that of apo-metallothionein treated with acid to cleave disulfide bonds.1 Publication
Molecular mass is 2431.5 Da from positions 1 - 24. Determined by MALDI. The measured mass is that of metallothionein with intact disulfide bonds chelating one cadmium ion.1 Publication
Molecular mass is 2541.5 Da from positions 1 - 24. Determined by MALDI. The measured mass is that of metallothionein with intact disulfide bonds chelating 2 cadmium ions.1 Publication

Cross-referencesi

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Cadmium induces a novel metallothionein and phytochelatin 2 in an aquatic fungus."
    Jaeckel P., Krauss G., Menge S., Schierhorn A., Ruecknagel P., Krauss G.J.
    Biochem. Biophys. Res. Commun. 333:150-155(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION, INDUCTION, MASS SPECTROMETRY, DISULFIDE BONDS, CADMIUM BINDING.
    Tissue: Mycelium1 Publication.

Entry informationi

Entry nameiMT1_NECLU
AccessioniPrimary (citable) accession number: P84865
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: October 1, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3