Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Metallothionein

Gene
N/A
Organism
Nectria lugdunensis (Aquatic fungus) (Heliscus lugdunensis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi3 – 31Cadmium1 Publication
Metal bindingi5 – 51Cadmium1 Publication
Metal bindingi8 – 81Cadmium1 Publication
Metal bindingi10 – 101Cadmium1 Publication
Metal bindingi14 – 141Cadmium1 Publication
Metal bindingi17 – 171Cadmium1 Publication
Metal bindingi19 – 191Cadmium1 Publication
Metal bindingi22 – 221Cadmium1 Publication

GO - Molecular functioni

  • metal chelating activity Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Cadmium, Metal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein
OrganismiNectria lugdunensis (Aquatic fungus) (Heliscus lugdunensis)
Taxonomic identifieri57155 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeNeonectria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 2424Metallothionein1 PublicationPRO_0000244521Add
BLAST

Post-translational modificationi

Contains 4 disulfide bonds.Curated

Keywords - PTMi

Disulfide bond

Expressioni

Inductioni

By cadmium.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the metallothionein superfamily. Type 8 family.Sequence analysis

Sequencei

Sequence statusi: Complete.

P84865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
SPCTCSTCNC AGACNSCSCT SCSH
Length:24
Mass (Da):2,331
Last modified:June 27, 2006 - v1
Checksum:i6568E5C8BE87E8FF
GO

Mass spectrometryi

Molecular mass is 2321.5 Da from positions 1 - 24. Determined by MALDI. The measured mass is that of apo-metallothionein with intact disulfide bonds.1 Publication
Molecular mass is 2329.7 Da from positions 1 - 24. Determined by MALDI. The measured mass is that of apo-metallothionein treated with acid to cleave disulfide bonds.1 Publication
Molecular mass is 2431.5 Da from positions 1 - 24. Determined by MALDI. The measured mass is that of metallothionein with intact disulfide bonds chelating one cadmium ion.1 Publication
Molecular mass is 2541.5 Da from positions 1 - 24. Determined by MALDI. The measured mass is that of metallothionein with intact disulfide bonds chelating 2 cadmium ions.1 Publication

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiMT1_NECLU
AccessioniPrimary (citable) accession number: P84865
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: April 29, 2015
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.