Reviewed, UniProtKB/Swiss-Prot P84864 (KAX6E_HADGE)

Names and origin

Protein names	Recommended name:     Potassium channel toxin alpha-KTx 6.14 Alternative name(s):     HgeTx1
Organism	Hadrurus gertschi (Scorpion)
Taxonomic identifier	380989 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Iurida › Iuroidea › Hadrurus

Protein attributes

Sequence length	36 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Blocks Shaker B channels expressed in Sf9 cells, with a dissociation constant of 52 nM. Ref.1
Subcellular location	Secreted Ref.1.
Tissue specificity	Expressed by the venom gland. Ref.1
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 6 subfamily.
Mass spectrometry	Molecular mass is 3950 Da from positions 1 - 36. Determined by ESI. Ref.1

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Ionic channel inhibitor Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 36	36	Potassium channel toxin alpha-KTx 6.14 Ref.1		PRO_0000273517
Amino acid modifications
	Disulfide bond	5 ↔ 25		Ref.1
	Disulfide bond	11 ↔ 30		Ref.1
	Disulfide bond	15 ↔ 32		Ref.1
	Disulfide bond	20 ↔ 35		Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P84864-1 [UniParc]. Last modified January 23, 2007. Version 1. Checksum: 36621175644DFCB8	FASTA	36	3,958
	10 20 30 TGTSCISPKQ CTEPCRAKGC KHGKCMNRKC HCMLCL

References

[1]

"HgeTx1, the first K(+)-channel specific toxin characterized from the venom of the scorpion Hadrurus gertschi Soleglad." Schwartz E.F., Schwartz C.A., Gomez-Lagunas F., Zamudio F.Z., Possani L.D. Toxicon 48:1046-1053(2006) [PubMed: 17030052] [Abstract] Cited for: PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY, DISULFIDE BONDS. Tissue: Venom.

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR001947. Scorpion_toxinS. [Graphical view]
Pfam	PF00451. Toxin_2. 1 hit. [Graphical view]
PRINTS	PR00286. CHARYBDTOXIN.
ProDom	PD003586. Scorpion_toxinS. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01138. SCORP_SHORT_TOXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAX6E_HADGE

Accession

Primary (citable) accession number: P84864

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	January 23, 2007
Last modified:	October 13, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Tox-Prot (Toxin Annotation Project)