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P84801 (GRFIN_GRISQ) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Griffithsin

Short name=GRFT
OrganismGriffithsia sp. (strain Q66D336) (Red alga)
Taxonomic identifier373036 [NCBI]
Taxonomic lineageEukaryotaRhodophytaFlorideophyceaeCeramialesCeramiaceaeGriffithsia

Protein attributes

Sequence length121 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mixed specificity lectin with anti-HIV activity. Binds to HIV envelope glycoproteins, including exterior membrane glycoprotein gp120, and inhibits viral entry into cells. Binding to gp120 is dependent on gp120 being glycosylated, and is inhibited by mannose, glucose and N-acetylglucosamine. Ref.1

Sequence similarities

Belongs to the jacalin lectin family.

Mass spectrometry

Molecular mass is 12770.05 Da from positions 1 - 121. Determined by ESI. Ref.1

Binary interactions

With

Entry

#Exp.

IntAct

Notes

envQ757602EBI-8453570,EBI-8453491From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 121121Griffithsin
PRO_0000228815

Secondary structure

................. 121
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P84801 [UniParc].

Last modified March 21, 2006. Version 1.
Checksum: F89843AF6DE5049D

FASTA12112,731
        10         20         30         40         50         60 
SLTHRKFGGS GGSPFSGLSS IAVRSGSYLD XIIIDGVHHG GSGGNLSPTF TFGSGEYISN 

        70         80         90        100        110        120 
MTIRSGDYID NISFETNMGR RFGPYGGSGG SANTLSNVKV IQINGSAGDY LDSLDIYYEQ 


Y 

« Hide

References

[1]"Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp."
Mori T., O'Keefe B.R., Sowder R.C. II, Bringans S., Gardella R., Berg S., Cochran P., Turpin J.A., Buckheit R.W. Jr., McMahon J.B., Boyd M.R.
J. Biol. Chem. 280:9345-9353(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2GTYX-ray1.30A/B1-121[»]
2GUCX-ray1.79A/B1-121[»]
2GUDX-ray0.94A/B1-121[»]
2GUEX-ray2.02A/B1-121[»]
2GUXX-ray2.00A1-121[»]
2HYQX-ray2.00A/B1-121[»]
2HYRX-ray1.51A/B1-121[»]
2NU5X-ray1.56A/B1-121[»]
2NUOX-ray1.50A/B1-121[»]
3LKYX-ray1.11A1-121[»]
3LL0X-ray1.70A1-121[»]
3LL1X-ray0.97A1-119[»]
3LL2X-ray0.97A1-121[»]
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-29130N.
IntActP84801. 1 interaction.
MINTMINT-8414712.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.100.10.30. 1 hit.
InterProIPR001229. Mannose-bd_lectin.
[Graphical view]
PfamPF01419. Jacalin. 1 hit.
[Graphical view]
SMARTSM00915. Jacalin. 1 hit.
[Graphical view]
SUPFAMSSF51101. SSF51101. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP84801.

Entry information

Entry nameGRFIN_GRISQ
AccessionPrimary (citable) accession number: P84801
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: July 9, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references