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Proteasome subunit alpha

Halococcus dombrowskii
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli


The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotationCurated

GO - Molecular functioni


Molecular functionHydrolase, Protease, Threonine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha (EC:
Alternative name(s):
Multicatalytic endopeptidase complex subunit alpha
OrganismiHalococcus dombrowskii
Taxonomic identifieri179637 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalococcaceaeHalococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000228814‹1 – ›12Proteasome subunit alphaAdd BLAST›12


Subunit structurei

Composed of two subunits, alpha and beta. The complex is formed of four rings. The two outer rings are each composed of seven alpha subunits. The two inner rings are each composed of seven beta subunits (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation


Sequence statusi: Fragment.

Mass (Da):1,306
Last modified:March 21, 2006 - v1

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei121

Similar proteinsi

Entry informationi

Entry nameiPSMA_HALDO
AccessioniPrimary (citable) accession number: P84799
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: August 30, 2017
This is version 23 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program


Keywords - Technical termi

Direct protein sequencing


  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families