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P84751

- HVM63_MOUSE

UniProt

P84751 - HVM63_MOUSE

Protein

Ig heavy chain Mem5

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (24 Jan 2006)
      Previous versions | rss
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    Functioni

    Anti-influenza H3N2 neuraminidase antibody.1 Publication

    GO - Molecular functioni

    1. antigen binding Source: UniProtKB-KW

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ig heavy chain Mem5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›237›237Ig heavy chain Mem5PRO_0000059901Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi22 ↔ 98By similarityPROSITE-ProRule annotation
    Disulfide bondi135 – 135Interchain (with a light chain)By similarityPROSITE-ProRule annotation
    Disulfide bondi147 ↔ 202By similarityPROSITE-ProRule annotation
    Disulfide bondi227 – 227Interchain (with a heavy chain)By similarityPROSITE-ProRule annotation
    Disulfide bondi230 – 230Interchain (with a heavy chain)By similarityPROSITE-ProRule annotation
    Disulfide bondi232 – 232Interchain (with a heavy chain)By similarityPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP84751.

    Expressioni

    Gene expression databases

    GenevestigatoriP84751.

    Structurei

    Secondary structure

    1
    237
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 86
    Beta strandi10 – 123
    Beta strandi18 – 2710
    Helixi29 – 313
    Beta strandi33 – 397
    Beta strandi45 – 517
    Helixi54 – 563
    Beta strandi60 – 623
    Turni64 – 663
    Helixi67 – 693
    Beta strandi70 – 756
    Helixi76 – 783
    Beta strandi80 – 856
    Helixi90 – 923
    Beta strandi94 – 1029
    Turni103 – 1053
    Beta strandi106 – 1105
    Beta strandi114 – 1185
    Beta strandi127 – 1315
    Helixi135 – 1384
    Beta strandi139 – 15517
    Beta strandi158 – 1614
    Helixi162 – 1643
    Beta strandi170 – 1723
    Beta strandi176 – 1783
    Beta strandi181 – 19111
    Turni192 – 1976
    Beta strandi201 – 2066
    Helixi207 – 2093
    Beta strandi211 – 2166

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ZANX-ray1.70H2-220[»]
    2ADFX-ray1.90H108-220[»]
    2AEPX-ray2.10H1-217[»]
    2AEQX-ray3.00H1-217[»]
    2G2RX-ray2.75B/H109-221[»]
    2G5BX-ray2.30F1-219[»]
    3BKCX-ray1.90H92-227[»]
    3BKJX-ray1.59H92-220[»]
    3BKMX-ray1.60H92-220[»]
    4HDIX-ray2.45B/H2-220[»]
    ProteinModelPortaliP84751.
    SMRiP84751. Positions 1-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP84751.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 119119Ig-like 1Sequence AnalysisAdd
    BLAST
    Domaini126 – 21893Ig-like 2Sequence AnalysisAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni101 – 1055D segmentBy similarity
    Regioni106 – 12015JH2 segment1 PublicationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 Ig-like (immunoglobulin-like) domains.Sequence Analysis

    Keywords - Domaini

    Immunoglobulin C region, Immunoglobulin domain, Immunoglobulin V region, Repeat

    Phylogenomic databases

    HOVERGENiHBG005814.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    SM00406. IGv. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P84751-1 [UniParc]FASTAAdd to Basket

    « Hide

    EVKLVESGGG LVQPGGSLSL SCATSGFTFI DYYMSWFRQP PGKALEWLGL    50
    IRNKGNGYTM EYSASLKGRF TISRDNSQSI VYLHMNTLTA EDSATYYCAR 100
    VDYGTNYDYW GQGTTLTVSS AKTTAPSVYP LAPVCGDTTG SSVTLGCLVK 150
    GYFPEPVTLT WNSGSLSSGV HTFPAVLQSD LYTLSSSVTV TSSTWPSQSI 200
    TCNVAHPASS TKVDKKIEPR GPTIKPCPPC KCPAPNS 237
    Length:237
    Mass (Da):25,350
    Last modified:January 24, 2006 - v1
    Checksum:i6BFABA1E6F835C10
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei237 – 2371Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ220746 mRNA. Translation: ABB81885.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ220746 mRNA. Translation: ABB81885.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ZAN X-ray 1.70 H 2-220 [» ]
    2ADF X-ray 1.90 H 108-220 [» ]
    2AEP X-ray 2.10 H 1-217 [» ]
    2AEQ X-ray 3.00 H 1-217 [» ]
    2G2R X-ray 2.75 B/H 109-221 [» ]
    2G5B X-ray 2.30 F 1-219 [» ]
    3BKC X-ray 1.90 H 92-227 [» ]
    3BKJ X-ray 1.59 H 92-220 [» ]
    3BKM X-ray 1.60 H 92-220 [» ]
    4HDI X-ray 2.45 B/H 2-220 [» ]
    ProteinModelPortali P84751.
    SMRi P84751. Positions 1-220.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    IMGTi Search...

    Proteomic databases

    PRIDEi P84751.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG005814.

    Miscellaneous databases

    EvolutionaryTracei P84751.

    Gene expression databases

    Genevestigatori P84751.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00406. IGv. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98)."
      Gulati U., Hwang C.C., Venkatramani L., Gulati S., Stray S.J., Lee J.T., Laver W.G., Bochkarev A., Zlotnick A., Air G.M.
      J. Virol. 76:12274-12280(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-19, NUCLEOTIDE SEQUENCE [MRNA] OF 20-237, FUNCTION.
      Strain: BALB/cImported.

    Entry informationi

    Entry nameiHVM63_MOUSE
    AccessioniPrimary (citable) accession number: P84751
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: January 24, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3