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Protein

Ig heavy chain Mem5

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Anti-influenza H3N2 neuraminidase antibody.1 Publication

GO - Molecular functioni

  1. antigen binding Source: UniProtKB-KW
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig heavy chain Mem5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›237›237Ig heavy chain Mem5PRO_0000059901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 98PROSITE-ProRule annotationBy similarity
Disulfide bondi135 – 135Interchain (with a light chain)PROSITE-ProRule annotationBy similarity
Disulfide bondi147 ↔ 202PROSITE-ProRule annotationBy similarity
Disulfide bondi227 – 227Interchain (with a heavy chain)PROSITE-ProRule annotationBy similarity
Disulfide bondi230 – 230Interchain (with a heavy chain)PROSITE-ProRule annotationBy similarity
Disulfide bondi232 – 232Interchain (with a heavy chain)PROSITE-ProRule annotationBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP84751.

Expressioni

Gene expression databases

GenevestigatoriP84751.

Structurei

Secondary structure

1
237
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86Combined sources
Beta strandi10 – 123Combined sources
Beta strandi18 – 2710Combined sources
Helixi29 – 313Combined sources
Beta strandi33 – 397Combined sources
Beta strandi45 – 517Combined sources
Helixi54 – 563Combined sources
Beta strandi60 – 623Combined sources
Turni64 – 663Combined sources
Helixi67 – 693Combined sources
Beta strandi70 – 756Combined sources
Helixi76 – 783Combined sources
Beta strandi80 – 856Combined sources
Helixi90 – 923Combined sources
Beta strandi94 – 1029Combined sources
Turni103 – 1053Combined sources
Beta strandi106 – 1105Combined sources
Beta strandi114 – 1185Combined sources
Beta strandi127 – 1315Combined sources
Helixi135 – 1384Combined sources
Beta strandi139 – 15517Combined sources
Beta strandi158 – 1614Combined sources
Helixi162 – 1643Combined sources
Beta strandi170 – 1723Combined sources
Beta strandi176 – 1783Combined sources
Beta strandi181 – 19111Combined sources
Turni192 – 1976Combined sources
Beta strandi201 – 2066Combined sources
Helixi207 – 2093Combined sources
Beta strandi211 – 2166Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZANX-ray1.70H2-220[»]
2ADFX-ray1.90H108-220[»]
2AEPX-ray2.10H1-217[»]
2AEQX-ray3.00H1-217[»]
2G2RX-ray2.75B/H109-221[»]
2G5BX-ray2.30F1-219[»]
3BKCX-ray1.90H92-227[»]
3BKJX-ray1.59H92-220[»]
3BKMX-ray1.60H92-220[»]
4HDIX-ray2.45B/H2-220[»]
ProteinModelPortaliP84751.
SMRiP84751. Positions 1-220.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84751.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 119119Ig-like 1Sequence AnalysisAdd
BLAST
Domaini126 – 21893Ig-like 2Sequence AnalysisAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni101 – 1055D segmentBy similarity
Regioni106 – 12015JH2 segment1 PublicationAdd
BLAST

Sequence similaritiesi

Contains 2 Ig-like (immunoglobulin-like) domains.Sequence Analysis

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Immunoglobulin V region, Repeat

Phylogenomic databases

HOVERGENiHBG005814.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P84751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EVKLVESGGG LVQPGGSLSL SCATSGFTFI DYYMSWFRQP PGKALEWLGL
60 70 80 90 100
IRNKGNGYTM EYSASLKGRF TISRDNSQSI VYLHMNTLTA EDSATYYCAR
110 120 130 140 150
VDYGTNYDYW GQGTTLTVSS AKTTAPSVYP LAPVCGDTTG SSVTLGCLVK
160 170 180 190 200
GYFPEPVTLT WNSGSLSSGV HTFPAVLQSD LYTLSSSVTV TSSTWPSQSI
210 220 230
TCNVAHPASS TKVDKKIEPR GPTIKPCPPC KCPAPNS
Length:237
Mass (Da):25,350
Last modified:January 24, 2006 - v1
Checksum:i6BFABA1E6F835C10
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei237 – 2371Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ220746 mRNA. Translation: ABB81885.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ220746 mRNA. Translation: ABB81885.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZANX-ray1.70H2-220[»]
2ADFX-ray1.90H108-220[»]
2AEPX-ray2.10H1-217[»]
2AEQX-ray3.00H1-217[»]
2G2RX-ray2.75B/H109-221[»]
2G5BX-ray2.30F1-219[»]
3BKCX-ray1.90H92-227[»]
3BKJX-ray1.59H92-220[»]
3BKMX-ray1.60H92-220[»]
4HDIX-ray2.45B/H2-220[»]
ProteinModelPortaliP84751.
SMRiP84751. Positions 1-220.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

IMGTiSearch...

Proteomic databases

PRIDEiP84751.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG005814.

Miscellaneous databases

EvolutionaryTraceiP84751.

Gene expression databases

GenevestigatoriP84751.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98)."
    Gulati U., Hwang C.C., Venkatramani L., Gulati S., Stray S.J., Lee J.T., Laver W.G., Bochkarev A., Zlotnick A., Air G.M.
    J. Virol. 76:12274-12280(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-19, NUCLEOTIDE SEQUENCE [MRNA] OF 20-237, FUNCTION.
    Strain: BALB/cImported.

Entry informationi

Entry nameiHVM63_MOUSE
AccessioniPrimary (citable) accession number: P84751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: April 1, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.