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P84751

- HVM63_MOUSE

UniProt

P84751 - HVM63_MOUSE

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Protein

Ig heavy chain Mem5

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Anti-influenza H3N2 neuraminidase antibody.1 Publication

GO - Molecular functioni

  1. antigen binding Source: UniProtKB-KW
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig heavy chain Mem5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›237›237Ig heavy chain Mem5PRO_0000059901Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 98 By similarityBy similarity
Disulfide bondi135 – 135Interchain (with a light chain) By similarityBy similarity
Disulfide bondi147 ↔ 202 By similarityBy similarity
Disulfide bondi227 – 227Interchain (with a heavy chain) By similarityBy similarity
Disulfide bondi230 – 230Interchain (with a heavy chain) By similarityBy similarity
Disulfide bondi232 – 232Interchain (with a heavy chain) By similarityBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP84751.

Expressioni

Gene expression databases

GenevestigatoriP84751.

Structurei

Secondary structure

1
237
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86
Beta strandi10 – 123
Beta strandi18 – 2710
Helixi29 – 313
Beta strandi33 – 397
Beta strandi45 – 517
Helixi54 – 563
Beta strandi60 – 623
Turni64 – 663
Helixi67 – 693
Beta strandi70 – 756
Helixi76 – 783
Beta strandi80 – 856
Helixi90 – 923
Beta strandi94 – 1029
Turni103 – 1053
Beta strandi106 – 1105
Beta strandi114 – 1185
Beta strandi127 – 1315
Helixi135 – 1384
Beta strandi139 – 15517
Beta strandi158 – 1614
Helixi162 – 1643
Beta strandi170 – 1723
Beta strandi176 – 1783
Beta strandi181 – 19111
Turni192 – 1976
Beta strandi201 – 2066
Helixi207 – 2093
Beta strandi211 – 2166

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZANX-ray1.70H2-220[»]
2ADFX-ray1.90H108-220[»]
2AEPX-ray2.10H1-217[»]
2AEQX-ray3.00H1-217[»]
2G2RX-ray2.75B/H109-221[»]
2G5BX-ray2.30F1-219[»]
3BKCX-ray1.90H92-227[»]
3BKJX-ray1.59H92-220[»]
3BKMX-ray1.60H92-220[»]
4HDIX-ray2.45B/H2-220[»]
ProteinModelPortaliP84751.
SMRiP84751. Positions 1-220.

Miscellaneous databases

EvolutionaryTraceiP84751.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 119119Ig-like 1Add
BLAST
Domaini126 – 21893Ig-like 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni101 – 1055D segment By similarityBy similarity
Regioni106 – 12015JH2 segment By similarityBy similarity1 PublicationAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Immunoglobulin V region, Repeat

Phylogenomic databases

HOVERGENiHBG005814.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P84751-1 [UniParc]FASTAAdd to Basket

« Hide

EVKLVESGGG LVQPGGSLSL SCATSGFTFI DYYMSWFRQP PGKALEWLGL    50
IRNKGNGYTM EYSASLKGRF TISRDNSQSI VYLHMNTLTA EDSATYYCAR 100
VDYGTNYDYW GQGTTLTVSS AKTTAPSVYP LAPVCGDTTG SSVTLGCLVK 150
GYFPEPVTLT WNSGSLSSGV HTFPAVLQSD LYTLSSSVTV TSSTWPSQSI 200
TCNVAHPASS TKVDKKIEPR GPTIKPCPPC KCPAPNS 237
Length:237
Mass (Da):25,350
Last modified:January 24, 2006 - v1
Checksum:i6BFABA1E6F835C10
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei237 – 2371

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ220746 mRNA. Translation: ABB81885.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ220746 mRNA. Translation: ABB81885.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ZAN X-ray 1.70 H 2-220 [» ]
2ADF X-ray 1.90 H 108-220 [» ]
2AEP X-ray 2.10 H 1-217 [» ]
2AEQ X-ray 3.00 H 1-217 [» ]
2G2R X-ray 2.75 B/H 109-221 [» ]
2G5B X-ray 2.30 F 1-219 [» ]
3BKC X-ray 1.90 H 92-227 [» ]
3BKJ X-ray 1.59 H 92-220 [» ]
3BKM X-ray 1.60 H 92-220 [» ]
4HDI X-ray 2.45 B/H 2-220 [» ]
ProteinModelPortali P84751.
SMRi P84751. Positions 1-220.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

IMGTi Search...

Proteomic databases

PRIDEi P84751.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005814.

Miscellaneous databases

EvolutionaryTracei P84751.

Gene expression databases

Genevestigatori P84751.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98)."
    Gulati U., Hwang C.C., Venkatramani L., Gulati S., Stray S.J., Lee J.T., Laver W.G., Bochkarev A., Zlotnick A., Air G.M.
    J. Virol. 76:12274-12280(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-19, NUCLEOTIDE SEQUENCE [MRNA] OF 20-237, FUNCTION.
    Strain: BALB/c.

Entry informationi

Entry nameiHVM63_MOUSE
AccessioniPrimary (citable) accession number: P84751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: July 9, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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