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P84751 (HVM63_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig heavy chain Mem5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length237 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Anti-influenza H3N2 neuraminidase antibody. Ref.1

Subcellular location

Secreted.

Sequence similarities

Contains 2 Ig-like (immunoglobulin-like) domains.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›237›237Ig heavy chain Mem5
PRO_0000059901

Regions

Domain1 – 119119Ig-like 1
Domain126 – 21893Ig-like 2
Region101 – 1055D segment By similarity UniProtKB P01783
Region106 – 12015JH2 segment By similarity Ref.1 UniProtKB P01783

Amino acid modifications

Disulfide bond22 ↔ 98 By similarity UniProtKB P01783
Disulfide bond135Interchain (with a light chain) By similarity UniProtKB P01863
Disulfide bond147 ↔ 202 By similarity UniProtKB P01863
Disulfide bond227Interchain (with a heavy chain) By similarity UniProtKB P01863
Disulfide bond230Interchain (with a heavy chain) By similarity UniProtKB P01863
Disulfide bond232Interchain (with a heavy chain) By similarity UniProtKB P01863

Experimental info

Non-terminal residue2371

Secondary structure

.................................................... 237
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P84751 [UniParc].

Last modified January 24, 2006. Version 1.
Checksum: 6BFABA1E6F835C10

FASTA23725,350
        10         20         30         40         50         60 
EVKLVESGGG LVQPGGSLSL SCATSGFTFI DYYMSWFRQP PGKALEWLGL IRNKGNGYTM 

        70         80         90        100        110        120 
EYSASLKGRF TISRDNSQSI VYLHMNTLTA EDSATYYCAR VDYGTNYDYW GQGTTLTVSS 

       130        140        150        160        170        180 
AKTTAPSVYP LAPVCGDTTG SSVTLGCLVK GYFPEPVTLT WNSGSLSSGV HTFPAVLQSD 

       190        200        210        220        230 
LYTLSSSVTV TSSTWPSQSI TCNVAHPASS TKVDKKIEPR GPTIKPCPPC KCPAPNS 

« Hide

References

[1]"Antibody epitopes on the neuraminidase of a recent H3N2 influenza virus (A/Memphis/31/98)."
Gulati U., Hwang C.C., Venkatramani L., Gulati S., Stray S.J., Lee J.T., Laver W.G., Bochkarev A., Zlotnick A., Air G.M.
J. Virol. 76:12274-12280(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-19, NUCLEOTIDE SEQUENCE [MRNA] OF 20-237, FUNCTION.
Strain: BALB/c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ220746 mRNA. Translation: ABB81885.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZANX-ray1.70H2-220[»]
2ADFX-ray1.90H108-220[»]
2AEPX-ray2.10H1-217[»]
2AEQX-ray3.00H1-217[»]
2G2RX-ray2.75B/H109-221[»]
2G5BX-ray2.30F1-219[»]
3BKCX-ray1.90H92-227[»]
3BKJX-ray1.59H92-220[»]
3BKMX-ray1.60H92-220[»]
4HDIX-ray2.45B/H2-220[»]
ProteinModelPortalP84751.
SMRP84751. Positions 1-220.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

IMGTSearch...

Proteomic databases

PRIDEP84751.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG005814.

Gene expression databases

GenevestigatorP84751.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP84751.

Entry information

Entry nameHVM63_MOUSE
AccessionPrimary (citable) accession number: P84751
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: July 9, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references