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Protein

Kappa-conotoxin Mo1659

Gene
N/A
Organism
Conus monile (Necklace cone)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits non-inactivating voltage-gated potassium channels in rat dorsal root ganglion neurons.1 Publication

Miscellaneous

The mature peptide does not contain cysteine residue.

GO - Molecular functioni

  • ion channel inhibitor activity Source: UniProtKB
  • potassium channel inhibitor activity Source: UniProtKB
  • toxin activity Source: UniProtKB-KW

GO - Biological processi

  • pathogenesis Source: UniProtKB

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-conotoxin Mo1659
OrganismiConus monile (Necklace cone)
Taxonomic identifieri351660 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000448841 – 13Kappa-conotoxin Mo1659Add BLAST13

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13Tyrosine amide1 Publication1

Keywords - PTMi

Amidation

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Sequencei

Sequence statusi: Complete.

Length:13
Mass (Da):1,660
Last modified:November 22, 2005 - v1
Checksum:i26D0AFA7570A1B43
GO

Mass spectrometryi

Molecular mass is 1659.1 Da from positions 1 - 13. Determined by MALDI. 1 Publication

Similar proteinsi

Entry informationi

Entry nameiCMO1_CONMO
AccessioniPrimary (citable) accession number: P84713
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: November 22, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing