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Protein

Palicourein

Gene
N/A
Organism
Palicourea condensata (Cappel)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probably participates in a plant defense mechanism. Inhibits the cytopathic effects of the human immunodeficiency virus.Curated1 Publication

GO - Biological processi

  • defense response Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Palicourein
OrganismiPalicourea condensata (Cappel)
Taxonomic identifieri272141 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsGentianalesRubiaceaeRubioideaePalicoureeaePalicourea

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 3737Palicourein1 PublicationPRO_0000044701Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki1 ↔ 37Cyclopeptide (Gly-Asn)2 Publications
Disulfide bondi6 ↔ 241 Publication
Disulfide bondi10 ↔ 261 Publication
Disulfide bondi16 ↔ 341 Publication

Post-translational modificationi

This is a cyclic peptide.2 Publications

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1
37
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi11 – 133Combined sources
Helixi19 – 224Combined sources
Beta strandi29 – 313Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R1FNMR-A4-37[»]
ProteinModelPortaliP84645.
SMRiP84645. Positions 4-37.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP84645.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.1 Publication

Sequence similaritiesi

Belongs to the cyclotide family.Sequence analysis

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR005535. Cyclotide.
[Graphical view]
PfamiPF03784. Cyclotide. 1 hit.
[Graphical view]
SUPFAMiSSF57038. SSF57038. 1 hit.

Sequencei

Sequence statusi: Complete.

P84645-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
GDPTFCGETC RVIPVCTYSA ALGCTCDDRS DGLCKRN
Length:37
Mass (Da):3,928
Last modified:September 13, 2005 - v1
Checksum:iF2E47EA83BDA960D
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R1FNMR-A4-37[»]
ProteinModelPortaliP84645.
SMRiP84645. Positions 4-37.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP84645.

Family and domain databases

InterProiIPR005535. Cyclotide.
[Graphical view]
PfamiPF03784. Cyclotide. 1 hit.
[Graphical view]
SUPFAMiSSF57038. SSF57038. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "A novel anti-HIV macrocyclic peptide from Palicourea condensata."
    Bokesch H.R., Pannell L.K., Cochran P.K., Sowder R.C. II, McKee T.C., Boyd M.R.
    J. Nat. Prod. 64:249-250(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, FUNCTION.
    Tissue: Bark1 Publication.
  2. "Solution structure of the cyclotide palicourein: implications for the development of a pharmaceutical framework."
    Barry D.G., Daly N.L., Bokesch H.R., Gustafson K.R., Craik D.J.
    Structure 12:85-94(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiPALIC_PALCO
AccessioniPrimary (citable) accession number: P84645
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: December 9, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

This peptide is cyclic. The start position was chosen by similarity to OAK1 (kalata-B1) for which the DNA sequence is known.Curated

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.