Reviewed, UniProtKB/Swiss-Prot P84625 (VHCA_ARCPR)

Names and origin

Protein names

Recommended name:
    F420-non-reducing hydrogenase iron-sulfur subunit A
    EC=1.12.99.-

Gene names

Name:

mvhA

Organism

Archaeoglobus profundus

Taxonomic identifier

84156 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Archaeoglobi › Archaeoglobales › Archaeoglobaceae › Archaeoglobus

Protein attributes

Sequence length	20 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Part of a complex that provides reducing equivalents for heterodisulfide reductase. Ref.1
Cofactor	Nickel. Ref.1
Subunit structure	The F420-non-reducing hydrogenase is composed of three subunits; mvhA, mvhD and mvhG. It forms a complex with the heterodisulfide reductase (Hdr). Ref.1
Subcellular location	Cytoplasm. Ref.1
Sequence similarities	Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nickel
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nickel ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›20	›20	F420-non-reducing hydrogenase iron-sulfur subunit A		PRO_0000199728
Experimental info
	Non-terminal residue	20	1

Sequences

	Sequence		Length	Mass (Da)
	P84625-1 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 1C70EA0CF794A303	FASTA	20	2,349
	10 20 MKKIEIEPMT RLEGHXKIAI

References

[1]

"Two distinct heterodisulfide reductase-like enzymes in the sulfate-reducing archaeon Archaeoglobus profundus." Mander G.J., Pierik A.J., Huber H., Hedderich R. Eur. J. Biochem. 271:1106-1116(2004) [PubMed: 15009189] [Abstract] Cited for: PROTEIN SEQUENCE, COFACTOR, INTERACTION WITH HETERODISULFIDE REDUCTASE, SUBCELLULAR LOCATION. Strain: AV18 / DSM 5631 / JCM 9629 / NBRC 100127.

Cross-references

3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR018194. Ni-dep_hyd_lsu_Ni_BS. [Graphical view]
PROSITE	PS00507. NI_HGENASE_L_1. Partial match. PS00508. NI_HGENASE_L_2. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VHCA_ARCPR

Accession

Primary (citable) accession number: P84625

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	August 30, 2005
Last modified:	June 16, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)