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P84586

- RMXRL_RAT

UniProt

P84586 - RMXRL_RAT

Protein

RNA-binding motif protein, X chromosome retrogene-like

Gene

Rbmxrtl

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of pre-mRNAs. Associates with chromatin. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Binds non-specifically to pre-mRNAs By similarity.By similarity

    GO - Molecular functioni

    1. mRNA binding Source: UniProtKB
    2. nucleotide binding Source: InterPro
    3. protein binding Source: UniProtKB
    4. RNA binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to interleukin-1 Source: UniProtKB
    2. membrane protein ectodomain proteolysis Source: UniProtKB
    3. mRNA splice site selection Source: UniProtKB
    4. multicellular organismal development Source: UniProtKB-KW
    5. negative regulation of mRNA splicing, via spliceosome Source: UniProtKB
    6. positive regulation of mRNA splicing, via spliceosome Source: UniProtKB
    7. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    8. protein homooligomerization Source: UniProtKB
    9. regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
    10. transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Ribonucleoprotein

    Keywords - Biological processi

    mRNA processing, mRNA splicing, Transcription

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-binding motif protein, X chromosome retrogene-like
    Alternative name(s):
    Heterogeneous nuclear ribonucleoprotein G retrogene-like
    Short name:
    hnRNP G
    RNA-binding motif protein, X chromosome retrogene
    Cleaved into the following chain:
    Gene namesi
    Name:Rbmxrtl
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1306751. Rbmxrtl.

    Subcellular locationi

    Nucleus By similarity
    Note: Component of ribonucleosomes.By similarity

    GO - Cellular componenti

    1. catalytic step 2 spliceosome Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProtKB
    3. nuclear euchromatin Source: UniProtKB
    4. nucleus Source: UniProtKB
    5. supraspliceosomal complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388RNA-binding motif protein, X chromosome retrogene-likePRO_0000081856Add
    BLAST
    Initiator methioninei1 – 11Removed; alternateBy similarity
    Chaini2 – 388387RNA-binding motif protein, X chromosome retrogene-like, N-terminally processedPRO_0000414744Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine; in RNA binding motif protein, X-linked-like-1; alternateBy similarity
    Modified residuei2 – 21N-acetylvaline; in RNA binding motif protein, X-linked-like-1, N-terminally processedBy similarity
    Modified residuei205 – 2051PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiP84586.
    PRIDEiP84586.

    PTM databases

    PhosphoSiteiP84586.

    Expressioni

    Gene expression databases

    GenevestigatoriP84586.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000016184.

    Structurei

    3D structure databases

    ProteinModelPortaliP84586.
    SMRiP84586. Positions 1-105.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 8679RRMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0724.
    HOGENOMiHOG000276235.
    HOVERGENiHBG063314.
    InParanoidiP84586.
    KOiK12885.
    PhylomeDBiP84586.
    TreeFamiTF331833.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR012604. RBM1CTR.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF08081. RBM1CTR. 1 hit.
    PF00076. RRM_1. 1 hit.
    [Graphical view]
    SMARTiSM00360. RRM. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P84586-1 [UniParc]FASTAAdd to Basket

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    MVEADRPGKL FIGGLNTETN EKALEAVFGK YGRIVEILLM KDRETNKSRG    50
    FAFVTFESPA DAKDVARDMN GKSLDGKAIK VEQATKPSFE SGRRGPPPPP 100
    RSRGPPRGLR GGSGGTRGPP SRGGYMDDGG YSMNFNMSSS RGPLPVKRGP 150
    PPRSGGPPPK RSTPSGPVRS SSGMGGRTPV SRGRDSYGGP PRREPLPSRR 200
    DVYLSPRDDG YSTKDSYSSR DYPSSRDTRD YAPPPRDYTY RDYSHSSSRD 250
    DYPSRGYGDR DGYGRDREYS DHPSGGSYRD SYESYGNSRS APPTRGPPPS 300
    YGGSSRYDDY SSSRDGYGGS RDSYSSSRSD LYSSGRDRVG RQERGLPPSM 350
    ERGYPPPRDS YSSSSRGAPR GGGRGGSRSD RGGGRSRY 388
    Length:388
    Mass (Da):42,204
    Last modified:July 19, 2005 - v1
    Checksum:iAFE8746592E44CF4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03113401 Genomic DNA. No translation available.
    RefSeqiNP_001100890.1. NM_001107420.1.
    UniGeneiRn.19966.

    Genome annotation databases

    GeneIDi307779.
    KEGGirno:307779.
    UCSCiRGD:1306751. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR03113401 Genomic DNA. No translation available.
    RefSeqi NP_001100890.1. NM_001107420.1.
    UniGenei Rn.19966.

    3D structure databases

    ProteinModelPortali P84586.
    SMRi P84586. Positions 1-105.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000016184.

    PTM databases

    PhosphoSitei P84586.

    Proteomic databases

    PaxDbi P84586.
    PRIDEi P84586.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 307779.
    KEGGi rno:307779.
    UCSCi RGD:1306751. rat.

    Organism-specific databases

    CTDi 307779.
    RGDi 1306751. Rbmxrtl.

    Phylogenomic databases

    eggNOGi COG0724.
    HOGENOMi HOG000276235.
    HOVERGENi HBG063314.
    InParanoidi P84586.
    KOi K12885.
    PhylomeDBi P84586.
    TreeFami TF331833.

    Miscellaneous databases

    NextBioi 657858.
    PROi P84586.

    Gene expression databases

    Genevestigatori P84586.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR012604. RBM1CTR.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF08081. RBM1CTR. 1 hit.
    PF00076. RRM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00360. RRM. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.

    Entry informationi

    Entry nameiRMXRL_RAT
    AccessioniPrimary (citable) accession number: P84586
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3