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P84586

- RMXRL_RAT

UniProt

P84586 - RMXRL_RAT

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Protein

RNA-binding motif protein, X chromosome retrogene-like

Gene
Rbmxrtl
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of pre-mRNAs. Associates with chromatin. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Binds non-specifically to pre-mRNAs By similarity.

GO - Molecular functioni

  1. mRNA binding Source: UniProtKB
  2. nucleotide binding Source: InterPro
  3. protein binding Source: UniProtKB
  4. RNA binding Source: UniProtKB

GO - Biological processi

  1. cellular response to interleukin-1 Source: UniProtKB
  2. membrane protein ectodomain proteolysis Source: UniProtKB
  3. mRNA splice site selection Source: UniProtKB
  4. multicellular organismal development Source: UniProtKB-KW
  5. negative regulation of mRNA splicing, via spliceosome Source: UniProtKB
  6. positive regulation of mRNA splicing, via spliceosome Source: UniProtKB
  7. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  8. protein homooligomerization Source: UniProtKB
  9. regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
  10. transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing, Transcription

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding motif protein, X chromosome retrogene-like
Alternative name(s):
Heterogeneous nuclear ribonucleoprotein G retrogene-like
Short name:
hnRNP G
RNA-binding motif protein, X chromosome retrogene
Cleaved into the following chain:
Gene namesi
Name:Rbmxrtl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1306751. Rbmxrtl.

Subcellular locationi

Nucleus By similarity
Note: Component of ribonucleosomes By similarity.

GO - Cellular componenti

  1. catalytic step 2 spliceosome Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProtKB
  3. nuclear euchromatin Source: UniProtKB
  4. nucleus Source: UniProtKB
  5. supraspliceosomal complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388RNA-binding motif protein, X chromosome retrogene-likePRO_0000081856Add
BLAST
Initiator methioninei1 – 11Removed; alternate By similarity
Chaini2 – 388387RNA-binding motif protein, X chromosome retrogene-like, N-terminally processedPRO_0000414744Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine; in RNA binding motif protein, X-linked-like-1; alternate By similarity
Modified residuei2 – 21N-acetylvaline; in RNA binding motif protein, X-linked-like-1, N-terminally processed By similarity
Modified residuei205 – 2051Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP84586.
PRIDEiP84586.

PTM databases

PhosphoSiteiP84586.

Expressioni

Gene expression databases

GenevestigatoriP84586.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016184.

Structurei

3D structure databases

ProteinModelPortaliP84586.
SMRiP84586. Positions 1-105.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 8679RRMAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0724.
HOGENOMiHOG000276235.
HOVERGENiHBG063314.
InParanoidiP84586.
KOiK12885.
PhylomeDBiP84586.
TreeFamiTF331833.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR012604. RBM1CTR.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF08081. RBM1CTR. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
PROSITEiPS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84586-1 [UniParc]FASTAAdd to Basket

« Hide

MVEADRPGKL FIGGLNTETN EKALEAVFGK YGRIVEILLM KDRETNKSRG    50
FAFVTFESPA DAKDVARDMN GKSLDGKAIK VEQATKPSFE SGRRGPPPPP 100
RSRGPPRGLR GGSGGTRGPP SRGGYMDDGG YSMNFNMSSS RGPLPVKRGP 150
PPRSGGPPPK RSTPSGPVRS SSGMGGRTPV SRGRDSYGGP PRREPLPSRR 200
DVYLSPRDDG YSTKDSYSSR DYPSSRDTRD YAPPPRDYTY RDYSHSSSRD 250
DYPSRGYGDR DGYGRDREYS DHPSGGSYRD SYESYGNSRS APPTRGPPPS 300
YGGSSRYDDY SSSRDGYGGS RDSYSSSRSD LYSSGRDRVG RQERGLPPSM 350
ERGYPPPRDS YSSSSRGAPR GGGRGGSRSD RGGGRSRY 388
Length:388
Mass (Da):42,204
Last modified:July 19, 2005 - v1
Checksum:iAFE8746592E44CF4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03113401 Genomic DNA. No translation available.
RefSeqiNP_001100890.1. NM_001107420.1.
UniGeneiRn.19966.

Genome annotation databases

GeneIDi307779.
KEGGirno:307779.
UCSCiRGD:1306751. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR03113401 Genomic DNA. No translation available.
RefSeqi NP_001100890.1. NM_001107420.1.
UniGenei Rn.19966.

3D structure databases

ProteinModelPortali P84586.
SMRi P84586. Positions 1-105.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016184.

PTM databases

PhosphoSitei P84586.

Proteomic databases

PaxDbi P84586.
PRIDEi P84586.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 307779.
KEGGi rno:307779.
UCSCi RGD:1306751. rat.

Organism-specific databases

CTDi 307779.
RGDi 1306751. Rbmxrtl.

Phylogenomic databases

eggNOGi COG0724.
HOGENOMi HOG000276235.
HOVERGENi HBG063314.
InParanoidi P84586.
KOi K12885.
PhylomeDBi P84586.
TreeFami TF331833.

Miscellaneous databases

NextBioi 657858.
PROi P84586.

Gene expression databases

Genevestigatori P84586.

Family and domain databases

Gene3Di 3.30.70.330. 1 hit.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR012604. RBM1CTR.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF08081. RBM1CTR. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view ]
SMARTi SM00360. RRM. 1 hit.
[Graphical view ]
PROSITEi PS50102. RRM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.

Entry informationi

Entry nameiRMXRL_RAT
AccessioniPrimary (citable) accession number: P84586
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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