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P84550

- SKOR1_HUMAN

UniProt

P84550 - SKOR1_HUMAN

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Protein

SKI family transcriptional corepressor 1

Gene

SKOR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling.By similarity

GO - Molecular functioni

  1. SMAD binding Source: UniProtKB
  2. transcription corepressor activity Source: Ensembl

GO - Biological processi

  1. negative regulation of BMP signaling pathway Source: UniProtKB
  2. negative regulation of transcription from RNA polymerase II promoter Source: RefGenome
  3. negative regulation of transforming growth factor beta receptor signaling pathway Source: RefGenome
  4. regulation of transcription, DNA-templated Source: UniProtKB
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SKI family transcriptional corepressor 1
Alternative name(s):
Functional Smad-suppressing element on chromosome 15
Short name:
Fussel-15
LBX1 corepressor 1
Ladybird homeobox corepressor 1
Gene namesi
Name:SKOR1
Synonyms:CORL1, FUSSEL15, LBXCOR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:21326. SKOR1.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. dendrite Source: UniProtKB
  3. neuronal cell body Source: UniProtKB
  4. nucleus Source: UniProtKB
  5. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165479509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 965965SKI family transcriptional corepressor 1PRO_0000129390Add
BLAST

Proteomic databases

PaxDbiP84550.
PRIDEiP84550.

PTM databases

PhosphoSiteiP84550.

Expressioni

Tissue specificityi

Present specifically in cerebellar Purkinje cells (at protein level).1 Publication

Gene expression databases

BgeeiP84550.
CleanExiHS_LBXCOR1.
ExpressionAtlasiP84550. baseline.
GenevestigatoriP84550.

Organism-specific databases

HPAiHPA040673.

Interactioni

Subunit structurei

Interacts with LBX1 (By similarity). Interacts with SMAD1, SMAD2 and SMAD3.By similarity1 Publication

Structurei

3D structure databases

ProteinModelPortaliP84550.
SMRiP84550. Positions 79-167, 183-272.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili858 – 92265Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SKI family.Sequence Analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG78967.
GeneTreeiENSGT00530000063040.
HOGENOMiHOG000293318.
HOVERGENiHBG081893.
InParanoidiP84550.
OMAiNRFPDEE.
OrthoDBiEOG7R56SW.
PhylomeDBiP84550.
TreeFamiTF324133.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProiIPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028762. SKOR1.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view]
PANTHERiPTHR10005. PTHR10005. 1 hit.
PTHR10005:SF8. PTHR10005:SF8. 1 hit.
PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]
SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P84550-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALLCGLGQV TLRIWVSLPS QSENGIGFLA ARAFLRSGGM EALTTQLGPG
60 70 80 90 100
REGSSSPNSK QELQPYSGSS ALKPNQVGET SLYGVPIVSL VIDGQERLCL
110 120 130 140 150
AQISNTLLKN YSYNEIHNRR VALGITCVQC TPVQLEILRR AGAMPISSRR
160 170 180 190 200
CGMITKREAE RLCKSFLGEH KPPKLPENFA FDVVHECAWG SRGSFIPARY
210 220 230 240 250
NSSRAKCIKC GYCSMYFSPN KFIFHSHRTP DAKYTQPDAA NFNSWRRHLK
260 270 280 290 300
LSDKSATDEL SHAWEDVKAM FNGGTRKRTF SLQGGGGGGA NGGSGGQGKG
310 320 330 340 350
GAGGGGGGGP GCGAEMAPGP PPHKSLRCGE DEAAGPPGPP PPHPQRGLGL
360 370 380 390 400
ATGASGPAGP GGPGGGAGVR SYPVIPVPSK GFGLLQKLPP PLFPHPYGFP
410 420 430 440 450
TAFGLCPKKD DPVLGAGEPK GGPGTGSGGG GAGTGGGAGG PGASHLPPGA
460 470 480 490 500
GAGPGGGAMF WGHQPSGAAK DAAAVAAAAA AATVYPTFPM FWPAAGSLPV
510 520 530 540 550
PSYPAAQSQA KAVAAAVAAA AAAAAAAAGS GAPEPLDGAE PAKESGLGAE
560 570 580 590 600
ERCPSALSRG PLDEDGTDEA LPPPLAPLPP PPPPPARKGS YVSAFRPVVK
610 620 630 640 650
DTESIAKLYG SAREAYGAGP ARGPGPGAGS GGYVSPDFLS EGSSSYNSAS
660 670 680 690 700
PDVDTADEPE VDVESNRFPD DEDAQEETEP SAPSAGGGPD GEQPTGPPSA
710 720 730 740 750
TSSGADGPAN SPDGGSPRPR RRLGPPPAGR PAFGDLAAED LVRRPERSPP
760 770 780 790 800
SGGGGYELRE PCGPLGGPAP AKVFAPERDE HVKSAAVALG PAASYVCTPE
810 820 830 840 850
AHEPDKEDNH SPADDLETRK SYPDQRSISQ PSPANTDRGE DGLTLDVTGT
860 870 880 890 900
HLVEKDIENL AREELQKLLL EQMELRKKLE REFQSLKDNF QDQMKRELAY
910 920 930 940 950
REEMVQQLQI VRDTLCNELD QERKARYAIQ QKLKEAHDAL HHFSCKMLTP
960
RHCTGNCSFK PPLLP
Length:965
Mass (Da):99,831
Last modified:June 21, 2005 - v1
Checksum:i313E95B0430A979B
GO
Isoform 2 (identifier: P84550-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MALLCGLGQV...GFLAARAFLR → MIPKSLVQAA...HVDLGGNQLW
     267-345: Missing.
     422-588: Missing.
     691-727: Missing.

Show »
Length:868
Mass (Da):93,779
Checksum:iA206B5ADFF8E8421
GO
Isoform 3 (identifier: P84550-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-36: Missing.
     277-311: Missing.

Note: No experimental confirmation available.

Show »
Length:921
Mass (Da):96,028
Checksum:i52DBF87B6324D49F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3636MALLC…RAFLR → MIPKSLVQAAETQRGLCEPG GKGREGRSGGKGETRPRGVG TQEGKGTIPGSPREKRGERG EGDPALLPAEDLWRLPGSKD RLRSSLLPPPGPPSSDSGPG PPSSHSGKTAQGPRTLNWAR KQSARTSSNLCAWSLAMATK MAEIPSSPYEPGQRGMKDTQ RGDAPQRGSPEPRILQLARV GNVYLKEESSRSGRLEAKKW IPTKFLENLSVPHVDLGGNQ LW in isoform 2. 1 PublicationVSP_033678Add
BLAST
Alternative sequencei28 – 369Missing in isoform 3. 1 PublicationVSP_040199
Alternative sequencei267 – 34579Missing in isoform 2. 1 PublicationVSP_033679Add
BLAST
Alternative sequencei277 – 31135Missing in isoform 3. 1 PublicationVSP_040200Add
BLAST
Alternative sequencei422 – 588167Missing in isoform 2. 1 PublicationVSP_033680Add
BLAST
Alternative sequencei691 – 72737Missing in isoform 2. 1 PublicationVSP_033681Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY669507 mRNA. Translation: AAV74188.1.
AC009292 Genomic DNA. No translation available.
BC168376 mRNA. Translation: AAI68376.1.
CCDSiCCDS58374.1. [P84550-2]
RefSeqiNP_001244953.1. NM_001258024.1. [P84550-2]
UniGeneiHs.451224.

Genome annotation databases

EnsembliENST00000341418; ENSP00000343200; ENSG00000188779. [P84550-2]
ENST00000380035; ENSP00000369374; ENSG00000188779. [P84550-1]
GeneIDi390598.
KEGGihsa:390598.
UCSCiuc031qsn.1. human. [P84550-2]

Polymorphism databases

DMDMi68052265.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY669507 mRNA. Translation: AAV74188.1 .
AC009292 Genomic DNA. No translation available.
BC168376 mRNA. Translation: AAI68376.1 .
CCDSi CCDS58374.1. [P84550-2 ]
RefSeqi NP_001244953.1. NM_001258024.1. [P84550-2 ]
UniGenei Hs.451224.

3D structure databases

ProteinModelPortali P84550.
SMRi P84550. Positions 79-167, 183-272.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P84550.

Polymorphism databases

DMDMi 68052265.

Proteomic databases

PaxDbi P84550.
PRIDEi P84550.

Protocols and materials databases

DNASUi 390598.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341418 ; ENSP00000343200 ; ENSG00000188779 . [P84550-2 ]
ENST00000380035 ; ENSP00000369374 ; ENSG00000188779 . [P84550-1 ]
GeneIDi 390598.
KEGGi hsa:390598.
UCSCi uc031qsn.1. human. [P84550-2 ]

Organism-specific databases

CTDi 390598.
GeneCardsi GC15P068113.
H-InvDB HIX0038482.
HGNCi HGNC:21326. SKOR1.
HPAi HPA040673.
MIMi 611273. gene.
neXtProti NX_P84550.
PharmGKBi PA165479509.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG78967.
GeneTreei ENSGT00530000063040.
HOGENOMi HOG000293318.
HOVERGENi HBG081893.
InParanoidi P84550.
OMAi NRFPDEE.
OrthoDBi EOG7R56SW.
PhylomeDBi P84550.
TreeFami TF324133.

Miscellaneous databases

GenomeRNAii 390598.
NextBioi 103908.
PROi P84550.
SOURCEi Search...

Gene expression databases

Bgeei P84550.
CleanExi HS_LBXCOR1.
ExpressionAtlasi P84550. baseline.
Genevestigatori P84550.

Family and domain databases

Gene3Di 3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProi IPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028762. SKOR1.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view ]
PANTHERi PTHR10005. PTHR10005. 1 hit.
PTHR10005:SF8. PTHR10005:SF8. 1 hit.
Pfami PF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view ]
SMARTi SM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling."
    Arndt S., Poser I., Moser M., Bosserhoff A.-K.
    Mol. Cell. Neurosci. 34:603-611(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH SMAD1; SMAD2 AND SMAD3.
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).

Entry informationi

Entry nameiSKOR1_HUMAN
AccessioniPrimary (citable) accession number: P84550
Secondary accession number(s): A6NIP4, A6NJY0, Q2VWA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3