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P84546 (ACCC_POPEU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biotin carboxylase

EC=6.3.4.14
Alternative name(s):
Acetyl-CoA carboxylase subunit A
Short name=ACC
EC=6.4.1.2
OrganismPopulus euphratica (Euphrates poplar)
Taxonomic identifier75702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesSalicaceaeSaliceaePopulus

Protein attributes

Sequence length40 AA.
Sequence statusFragments.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA By similarity. UniProtKB Q06862

Catalytic activity

ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.

Pathway

Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.

Subunit structure

Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex By similarity.

Sequence similarities

Contains 1 ATP-grasp domain. UniProtKB Q06862

Contains 1 biotin carboxylation domain. UniProtKB Q06862

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›40›40Biotin carboxylase
PRO_0000146795

Regions

Domain‹1 – ›40›40Biotin carboxylation
Domain‹13 – ›27›15ATP-grasp

Experimental info

Non-adjacent residues12 – 132
Non-adjacent residues27 – 282
Non-terminal residue11
Non-terminal residue401

Sequences

Sequence LengthMass (Da)Tools
P84546 [UniParc].

Last modified June 21, 2005. Version 1.
Checksum: 1D3B610C28C4E4D1

FASTA404,288
        10         20         30         40 
ILVANRGEIA VRLLEEAPSP ALTPELRITA YLPSGGPFVR 

« Hide

References

[1]"Proteome profiling of Populus euphratica Oliv. upon heat stress."
Ferreira S., Hjernoe K., Larsen M., Wingsle G., Larsen P., Fey S., Roepstorff P., Pais M.S.
Ann. Bot. 98:361-377(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Leaf.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP84546.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00655; UER00711.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameACCC_POPEU
AccessionPrimary (citable) accession number: P84546
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: February 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways