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Biotin carboxylase

Populus euphratica (Euphrates poplar)
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli


This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.By similarity

Catalytic activityi

ATP + biotin-[carboxyl-carrier-protein] + HCO3- = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].By similarity
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.By similarity


Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic (accD), Biotin carboxylase
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...


Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Biotin, Magnesium, Manganese, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin carboxylase (EC:
Alternative name(s):
Acetyl-CoA carboxylase subunit A (EC:
Short name:
OrganismiPopulus euphratica (Euphrates poplar)
Taxonomic identifieri75702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesSalicaceaeSaliceaePopulus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000146795‹1 – ›40Biotin carboxylaseAdd BLAST›40

Proteomic databases



Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – ›40Biotin carboxylationSequence analysisAdd BLAST›40
Domaini‹13 – ›27ATP-graspPROSITE-ProRule annotationAdd BLAST›15

Sequence similaritiesi

Contains 1 ATP-grasp domain.PROSITE-ProRule annotationBy similarity
Contains 1 biotin carboxylation domain.By similarity

Family and domain databases

Gene3Di3.40.50.20. 1 hit.
InterProiIPR016185. PreATP-grasp_dom.
[Graphical view]


Sequence statusi: Fragments.

P84546-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40
Mass (Da):4,288
Last modified:June 21, 2005 - v1

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-adjacent residuesi12 – 13Curated2
Non-adjacent residuesi27 – 28Curated2
Non-terminal residuei401


3D structure databases


Proteomic databases


Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Family and domain databases

Gene3Di3.40.50.20. 1 hit.
InterProiIPR016185. PreATP-grasp_dom.
[Graphical view]

Entry informationi

Entry nameiACCC_POPEU
AccessioniPrimary (citable) accession number: P84546
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: November 30, 2016
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program


Keywords - Technical termi

Direct protein sequencing


  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.