Reviewed, UniProtKB/Swiss-Prot P84546 (ACCC_POPEU)

Names and origin

Protein names	Recommended name:     Biotin carboxylase     EC=6.3.4.14 Alternative name(s):     Acetyl-CoA carboxylase subunit A       Short name=ACC     EC=6.4.1.2
Organism	Populus euphratica (Euphrates poplar)
Taxonomic identifier	75702 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Malpighiales › Salicaceae › Saliceae › Populus

Protein attributes

Sequence length	40 AA.
Sequence status	Fragments.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA By similarity. UniProtKB Q06862
Catalytic activity	ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein. UniProtKB Q06862 ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
Pathway	Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
Subunit structure	Acetyl-CoA carboxylase is an heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex By similarity. UniProtKB Q06862
Sequence similarities	Contains 1 ATP-grasp domain. Contains 1 biotin carboxylation domain.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Ligand	ATP-binding Biotin Nucleotide-binding
Molecular function	Ligase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetyl-CoA carboxylase activity Inferred from electronic annotation. Source: EC biotin carboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›40	›40	Biotin carboxylase		PRO_0000146795
Regions
	Domain	‹1 – ›40	›40	Biotin carboxylation
	Domain	‹13 – ›27	›15	ATP-grasp
Experimental info
	Non-adjacent residues	12 – 13	2
	Non-adjacent residues	27 – 28	2
	Non-terminal residue	1	1
	Non-terminal residue	40	1

Sequences

	Sequence		Length	Mass (Da)
	P84546-1 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: 1D3B610C28C4E4D1	FASTA	40	4,288
	10 20 30 40 ILVANRGEIA VRLLEEAPSP ALTPELRITA YLPSGGPFVR

References

[1]	"Proteome profiling of Populus euphratica Oliv. upon heat stress." Ferreira S., Hjernoe K., Larsen M., Wingsle G., Larsen P., Fey S., Roepstorff P., Pais M.S. Ann. Bot. 98:361-377(2006) [PubMed: 16740589] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Leaf.

Cross-references

3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	6.3.4.14. 293088. 6.4.1.2. 293088.
Family and domain databases
PROSITE	PS50975. ATP_GRASP. Partial match. PS50979. BC. Partial match. PS00866. CPSASE_1. Partial match. PS00867. CPSASE_2. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACCC_POPEU

Accession

Primary (citable) accession number: P84546

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	June 21, 2005
Last modified:	February 9, 2010
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)