Reviewed, UniProtKB/Swiss-Prot P84545 (DLDH_POPEU)

Names and origin

Protein names	Recommended name:     Dihydrolipoyl dehydrogenase     EC=1.8.1.4 Alternative name(s):     Dihydrolipoamide dehydrogenase
Organism	Populus euphratica (Euphrates poplar)
Taxonomic identifier	75702 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Malpighiales › Salicaceae › Saliceae › Populus

Protein attributes

Sequence length	11 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. The pyruvate dehydrogenase complex contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. UniProtKB P09622
Catalytic activity	Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH. UniProtKB P09622
Cofactor	Binds 1 FAD per subunit By similarity. UniProtKB P14218
Subunit structure	Homodimer By similarity. UniProtKB P09622
Miscellaneous	The active site is a redox-active disulfide bond.
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
Domain	Redox-active center
Ligand	FAD Flavoprotein NAD
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	dihydrolipoyl dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›11	›11	Dihydrolipoyl dehydrogenase		PRO_0000068011
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	11	1

Sequences

	Sequence		Length	Mass (Da)
	P84545-1 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: C2E56DC3D7273769	FASTA	11	1,201
	10 VGKFPLLANS R

References

[1]	"Proteome profiling of Populus euphratica Oliv. upon heat stress." Ferreira S., Hjernoe K., Larsen M., Wingsle G., Larsen P., Fey S., Roepstorff P., Pais M.S. Ann. Bot. 98:361-377(2006) [PubMed: 16740589] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Leaf.

Cross-references

3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.8.1.4. 293088.
Family and domain databases
InterPro	IPR012999. Pyr_OxRdtase_I_AS. [Graphical view]
PROSITE	PS00076. PYRIDINE_REDOX_1. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DLDH_POPEU

Accession

Primary (citable) accession number: P84545

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	June 21, 2005
Last modified:	January 20, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)