Reviewed, UniProtKB/Swiss-Prot P84532 (SAHH2_POPEU)

Names and origin

Protein names	Recommended name:     Adenosylhomocysteinase 2       Short name=AdoHcyase     EC=3.3.1.1 Alternative name(s):     S-adenosyl-L-homocysteine hydrolase
Organism	Populus euphratica (Euphrates poplar)
Taxonomic identifier	75702 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Malpighiales › Salicaceae › Saliceae › Populus

Protein attributes

Sequence length	13 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine By similarity. UniProtKB P35007
Catalytic activity	S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. UniProtKB P35007
Cofactor	Binds 1 NAD per subunit By similarity. UniProtKB P35007
Pathway	Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
Subunit structure	Homotetramer By similarity. UniProtKB P35007
Sequence similarities	Belongs to the adenosylhomocysteinase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	NAD
Molecular function	Hydrolase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	adenosylhomocysteinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›13	›13	Adenosylhomocysteinase 2		PRO_0000116931
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	13	1

Sequences

	Sequence		Length	Mass (Da)
	P84532-1 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: 897A15F878D276C5	FASTA	13	1,364
	10 AEFGPSQPFK GAK

References

[1]	"Proteome profiling of Populus euphratica Oliv. upon heat stress." Ferreira S., Hjernoe K., Larsen M., Wingsle G., Larsen P., Fey S., Roepstorff P., Pais M.S. Ann. Bot. 98:361-377(2006) [PubMed: 16740589] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Leaf.

Cross-references

3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	3.3.1.1. 293088.
Family and domain databases
InterPro	IPR020082. S-Ado-L-homoCys_hydrolase_CS. [Graphical view]
PROSITE	PS00738. ADOHCYASE_1. Partial match. PS00739. ADOHCYASE_2. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SAHH2_POPEU

Accession

Primary (citable) accession number: P84532

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	June 21, 2005
Last modified:	September 22, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)