Reviewed, UniProtKB/Swiss-Prot P84520 (ADA2_CHICK)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase 2
    EC=3.5.4.4

Gene names

Name:

ADA2

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	12 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. Ref.1
Enzyme regulation	Inhibited by adenosine deaminase inhibitor 2-DCF, but not by adenosine deaminase 1 inhibitor EHNA. Ref.1
Subunit structure	Homodimer. Ref.1
Post-translational modification	N-glycosylated. Ref.1
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Ref.1
Biophysicochemical properties	Kinetic parameters: KM=144 µM for adenosine Ref.1 KM=333 µM for 2-deoxyadenosine Ref.1 pH dependence: Optimum pH is 6.5. Ref.1

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›12	›12	Adenosine deaminase 2		PRO_0000194359
Experimental info
	Non-terminal residue	12	1

Sequences

	Sequence		Length	Mass (Da)
	P84520-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 8A03AE7AB2D69735	FASTA	12	1,466
	10 TPLWSLMQDL MM

References

[1]

"Adenosine deaminase 2 from chicken liver: purification, characterization, and N-terminal amino acid sequence." Iwaki-Egawa S., Namiki C., Watanabe Y. Comp. Biochem. Physiol. 137B:247-254(2004) [PubMed: 14990221] [Abstract] Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, ENZYME REGULATION, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT, GLYCOSYLATION. Tissue: Liver.

Cross-references

Sequence databases
IPI	IPI00591434.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P84520.
Enzyme and pathway databases
BRENDA	3.5.4.4. 4.
Family and domain databases
InterPro	IPR006650. A/AMP_deam_AS. [Graphical view]
PROSITE	PS00485. A_DEAMINASE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADA2_CHICK

Accession

Primary (citable) accession number: P84520

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	February 10, 2009
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)