Reviewed, UniProtKB/Swiss-Prot P84492 (LYSC_CHEMY)

Names and origin

Protein names

Recommended name:
    Lysozyme C
    EC=3.2.1.17
Alternative name(s):
    1,4-beta-N-acetylmuramidase C

Gene names

Name:

LYZ

Organism

Chelonia mydas (Green sea-turtle) (Chelonia agassizi)

Taxonomic identifier

8469 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Testudines › Cryptodira › Chelonioidea › Cheloniidae › Chelonia

Protein attributes

Sequence length	130 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents By similarity.
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
Subunit structure	Monomer By similarity.
Miscellaneous	Lysozyme C is capable of both hydrolysis and transglycosylation; it shows also a slight esterase activity. It acts rapidly on both peptide-substituted and unsubstituted peptidoglycan, and slowly on chitin oligosaccharides.
Sequence similarities	Belongs to the glycosyl hydrolase 22 family.

Ontologies

Keywords
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 130	130	Lysozyme C		PRO_0000247815
Sites
	Active site	35	1	By similarity
	Active site	53	1	By similarity
Amino acid modifications
	Disulfide bond	6 ↔ 128		By similarity
	Disulfide bond	30 ↔ 116		By similarity
	Disulfide bond	65 ↔ 81		By similarity
	Disulfide bond	77 ↔ 95		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P84492-1 [UniParc]. Last modified March 29, 2005. Version 1. Checksum: 4CBB271A77565168	FASTA	130	14,704
	10 20 30 40 50 60 KTYERCELAR AMKRLGLDGY WGYSLGHWVC AAKYESNFNT GATNYNPGDQ STDYGILQIN 70 80 90 100 110 120 SRWWCNDGKT PRTKNACKIQ CRELLTADIT ASVNCAKRVV RDPNGMGAWV AWTKNCKGRD 130 VSPWIRDCGL

References

[1]	Araki T., Chijiiwa Y., Okabayashi K., Kawase M., Kamesaki M., Torikata T. Submitted (MAR-2003) to the PIR data bank Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	JC7918.
3D structure databases
SMR	P84492. Positions 1-130.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P84492.
Enzyme and pathway databases
BRENDA	3.2.1.17. 293409.
Family and domain databases
InterPro	IPR001916. Glyco_hydro_22. IPR019799. Glyco_hydro_22_CS. IPR000974. Glyco_hydro_22_lys. [Graphical view]
Pfam	PF00062. Lys. 1 hit. [Graphical view]
PRINTS	PR00137. LYSOZYME. PR00135. LYZLACT.
SMART	SM00263. LYZ1. 1 hit. [Graphical view]
PROSITE	PS00128. LACTALBUMIN_LYSOZYME_1. 1 hit. PS51348. LACTALBUMIN_LYSOZYME_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LYSC_CHEMY

Accession

Primary (citable) accession number: P84492

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	March 29, 2005
Last modified:	June 16, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)