Reviewed, UniProtKB/Swiss-Prot P84463 (AL7A1_CTEID)

Names and origin

Protein names

Recommended name:
    Alpha-aminoadipic semialdehyde dehydrogenase
      Short name=Alpha-AASA dehydrogenase
    EC=1.2.1.31
Alternative name(s):
    Delta1-piperideine-6-carboxylate dehydrogenease
      Short name=P6c dehydrogenase
    Aldehyde dehydrogenase family 7 member A1
    Antiquitin-1

Gene names

Name:

aldh7a1

Organism

Ctenopharyngodon idella (Grass carp)

Taxonomic identifier

7959 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Ctenopharyngodon

Protein attributes

Sequence length	21 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	L-2-aminoadipate 6-semialdehyde + NAD(P)(+) + H(2)O = L-2-aminoadipate + NAD(P)H.
Subunit structure	Homotetramer.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.
Biophysicochemical properties	Kinetic parameters: KM=2.0 mM for acetaldehyde Vmax=1.95 µmol/min/mg enzyme pH dependence: Optimum pH is 9-10.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-aminoadipate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›21	›21	Alpha-aminoadipic semialdehyde dehydrogenase		PRO_0000056494
Experimental info
	Non-terminal residue	21	1

Sequences

	Sequence		Length	Mass (Da)
	P84463-1 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: A69E54BB27B2EF1A	FASTA	21	2,289
	10 20 SALAINQPNY SVLKELGLNE D

References

[1]

"Purification, N-terminal sequence determination and enzymatic characterization of antiquitin from the liver of grass carp." Chan W.-M., Tang W.-K., Cheng C.H., Fong W.-P. Comp. Biochem. Physiol. 136B:443-450(2003) [PubMed: 14602152] [Abstract] Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT. Tissue: Liver.

Cross-references

3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P84463.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. Partial match. PS00687. ALDEHYDE_DEHYDR_GLU. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL7A1_CTEID

Accession

Primary (citable) accession number: P84463

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	November 4, 2008
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)