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P84463 (AL7A1_CTEID) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-aminoadipic semialdehyde dehydrogenase

Short name=Alpha-AASA dehydrogenase
EC=1.2.1.31
Alternative name(s):
Aldehyde dehydrogenase family 7 member A1
Antiquitin-1
Delta1-piperideine-6-carboxylate dehydrogenase
Short name=P6c dehydrogenase
Gene names
Name:aldh7a1
OrganismCtenopharyngodon idella (Grass carp) (Leuciscus idella)
Taxonomic identifier7959 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCtenopharyngodon

Protein attributes

Sequence length21 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H. Ref.1

Subunit structure

Homotetramer. Ref.1

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Biophysicochemical properties

Kinetic parameters:

KM=2.0 mM for acetaldehyde Ref.1

Vmax=1.95 µmol/min/mg enzyme Ref.1

pH dependence:

Optimum pH is 9-10. Ref.1

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Molecular_functionL-aminoadipate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›21›21Alpha-aminoadipic semialdehyde dehydrogenase
PRO_0000056494

Experimental info

Non-terminal residue211

Sequences

Sequence LengthMass (Da)Tools
P84463 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: A69E54BB27B2EF1A

FASTA212,289
        10         20 
SALAINQPNY SVLKELGLNE D 

« Hide

References

[1]"Purification, N-terminal sequence determination and enzymatic characterization of antiquitin from the liver of grass carp."
Chan W.-M., Tang W.-K., Cheng C.H., Fong W.-P.
Comp. Biochem. Physiol. 136B:443-450(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT.
Tissue: Liver.

Cross-references

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKP84463.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameAL7A1_CTEID
AccessionPrimary (citable) accession number: P84463
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families