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Protein

C-C motif chemokine 21a

Gene

Ccl21a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.

GO - Molecular functioni

  • CCR7 chemokine receptor binding Source: BHF-UCL
  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: BHF-UCL
  • chemokine receptor binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 21a
Alternative name(s):
6Ckine
Beta-chemokine exodus-2
Small-inducible cytokine A21a
Thymus-derived chemotactic agent 4
Short name:
TCA4
Gene namesi
Name:Ccl21a
Synonyms:Scya21, Scya21a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1349183. Ccl21a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Mice carrying an autosomal recessive mutation designated paucity of lymph node T-cells (plt) show dramatically reduced numbers of T-cells in lymph nodes, Peyer patches, and the white pulp of the spleen. Plt seems to correspond to Scya21b.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000522324 – 133C-C motif chemokine 21aAdd BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 57By similarity
Disulfide bondi32 ↔ 75By similarity
Disulfide bondi103 ↔ 122Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP84444.
PaxDbiP84444.
PeptideAtlasiP84444.
PRIDEiP84444.

Expressioni

Tissue specificityi

Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart.

Gene expression databases

BgeeiENSMUSG00000094686.
CleanExiMM_CCL21B.
GenevisibleiP84444. MM.

Interactioni

Subunit structurei

Binds to CCR7 and to CXCR3.

GO - Molecular functioni

  • CCR7 chemokine receptor binding Source: BHF-UCL
  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: BHF-UCL
  • chemokine receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136780.

Structurei

3D structure databases

ProteinModelPortaliP84444.
SMRiP84444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 133C-terminal basic extensionAdd BLAST36

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3QM. Eukaryota.
ENOG410Z7F2. LUCA.
GeneTreeiENSGT00730000111297.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP84444.
KOiK16062.
OMAiCKRTEQP.
OrthoDBiEOG091G14NY.
PhylomeDBiP84444.
TreeFamiTF338224.

Family and domain databases

InterProiIPR030593. CCL21.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF72. PTHR12015:SF72. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P84444-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQMMTLSLL SLVLALCIPW TQGSDGGGQD CCLKYSQKKI PYSIVRGYRK
60 70 80 90 100
QEPSLGCPIP AILFSPRKHS KPELCANPEE GWVQNLMRRL DQPPAPGKQS
110 120 130
PGCRKNRGTS KSGKKGKGSK GCKRTEQTQP SRG
Length:133
Mass (Da):14,558
Last modified:March 1, 2005 - v1
Checksum:iABD2750A320B3719
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001980 mRNA. Translation: AAB86595.1.
AF006637 mRNA. Translation: AAB61440.1.
AF171086 Genomic DNA. Translation: AAF16901.1.
AF035684 Genomic DNA. Translation: AAC82613.1.
AF307985 Genomic DNA. Translation: AAG45833.1.
AK144258 mRNA. Translation: BAE25802.1.
AK155924 mRNA. Translation: BAE33505.1.
AL772334 Genomic DNA. No translation available.
BC025974 mRNA. Translation: AAH25974.1.
BC028747 mRNA. Translation: AAH28747.1.
BC038120 mRNA. Translation: AAH38120.1.
CCDSiCCDS18081.1.
RefSeqiNP_001180596.1. NM_001193667.1.
NP_035254.1. NM_011124.4.
UniGeneiMm.220853.
Mm.458815.

Genome annotation databases

EnsembliENSMUST00000095114; ENSMUSP00000092732; ENSMUSG00000094686.
ENSMUST00000178919; ENSMUSP00000136780; ENSMUSG00000095320.
GeneIDi100504362.
18829.
KEGGimmu:100504362.
mmu:18829.
UCSCiuc008sny.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001980 mRNA. Translation: AAB86595.1.
AF006637 mRNA. Translation: AAB61440.1.
AF171086 Genomic DNA. Translation: AAF16901.1.
AF035684 Genomic DNA. Translation: AAC82613.1.
AF307985 Genomic DNA. Translation: AAG45833.1.
AK144258 mRNA. Translation: BAE25802.1.
AK155924 mRNA. Translation: BAE33505.1.
AL772334 Genomic DNA. No translation available.
BC025974 mRNA. Translation: AAH25974.1.
BC028747 mRNA. Translation: AAH28747.1.
BC038120 mRNA. Translation: AAH38120.1.
CCDSiCCDS18081.1.
RefSeqiNP_001180596.1. NM_001193667.1.
NP_035254.1. NM_011124.4.
UniGeneiMm.220853.
Mm.458815.

3D structure databases

ProteinModelPortaliP84444.
SMRiP84444.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000136780.

Proteomic databases

MaxQBiP84444.
PaxDbiP84444.
PeptideAtlasiP84444.
PRIDEiP84444.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095114; ENSMUSP00000092732; ENSMUSG00000094686.
ENSMUST00000178919; ENSMUSP00000136780; ENSMUSG00000095320.
GeneIDi100504362.
18829.
KEGGimmu:100504362.
mmu:18829.
UCSCiuc008sny.2. mouse.

Organism-specific databases

CTDi18829.
MGIiMGI:1349183. Ccl21a.

Phylogenomic databases

eggNOGiENOG410J3QM. Eukaryota.
ENOG410Z7F2. LUCA.
GeneTreeiENSGT00730000111297.
HOGENOMiHOG000036685.
HOVERGENiHBG017871.
InParanoidiP84444.
KOiK16062.
OMAiCKRTEQP.
OrthoDBiEOG091G14NY.
PhylomeDBiP84444.
TreeFamiTF338224.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiP84444.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000094686.
CleanExiMM_CCL21B.
GenevisibleiP84444. MM.

Family and domain databases

InterProiIPR030593. CCL21.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR12015:SF72. PTHR12015:SF72. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCC21A_MOUSE
AccessioniPrimary (citable) accession number: P84444
Secondary accession number(s): O09002
, O09006, Q3U1J2, Q91V84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Three genes code for Ccl21 in mouse. Ccl21b and Ccl21c produce identical proteins while the protein produced by Ccl21a differs at only one position. Ccl21b and Ccl21c have 'Leu-65' (6Ckine-Leu) while Ccl21a has Ser-65 (6Ckine-Ser).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.