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Homo sapiens neanderthalensis (Neanderthal)
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli


Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.Curated


Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi2Calcium 2By similarity1
Metal bindingi5Calcium 1By similarity1
Metal bindingi5Calcium 2By similarity1
Metal bindingi11Calcium 1By similarity1

GO - Molecular functioni

GO - Biological processi


Biological processBiomineralization
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alternative name(s):
Bone Gla protein
Short name:
Gamma-carboxyglutamic acid-containing protein
Gene namesi
Name:BGLAPBy similarity
OrganismiHomo sapiens neanderthalensis (Neanderthal)
Taxonomic identifieri63221 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti


PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000148899‹1 – ›24OsteocalcinAdd BLAST›24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Disulfide bondi4 ↔ 10PROSITE-ProRule annotationBy similarity
Modified residuei54-carboxyglutamatePROSITE-ProRule annotationBy similarity1

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.Curated

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini‹1 – ›24GlaPROSITE-ProRule annotationAdd BLAST›24

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR000294. GLA_domain.
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiView protein in PROSITE
PS50998. GLA_2. 1 hit.


Sequence statusi: Fragment.

P84351-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
Mass (Da):2,823
Last modified:April 12, 2005 - v1

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11 Publication1
Non-terminal residuei241 Publication1

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiOSTCN_HOMNE
AccessioniPrimary (citable) accession number: P84351
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: February 15, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.


Keywords - Technical termi

Direct protein sequencing, Extinct organism protein


  1. SIMILARITY comments
    Index of protein domains and families